Get George Clooney and Renée Zellweger in a room together and the pair riff off each other like a practiced comedy duo.

Asked by W magazine recently how long they've known each other, Zellweger, who stars with Clooney in next year's Leatherheads, cracks, "Oh, God. Twenty-five, 30 years."

"Thirty-five years," Clooney, who also directs the movie, adds.

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