11/10/2009 05:12 am ET | Updated May 25, 2011

The Female Economy: Time Names The Top Women In Fashion

Always energetic, often to the point of frenetic nervousness, Karan is described by those who know her best as "passionate," "wild," "insane" and, at times, "cuckoo." It's no surprise, then, that the runways have never been able to contain the Queens-born Karan. She still ends the program notes of her shows with the phrase "To be continued," reflecting her conviction that her education in style, design and inspiration is an ever evolving process -- one that often takes her far beyond runways and studios.