David Letterman Jokes About Affairs, Wife's Reaction In Monologue (VIDEO)

03/18/2010 05:12 am ET | Updated May 25, 2011

David Letterman addressed his infidelity tonight on the "Late Show," both by joking about his affairs and by apologizing to his now wife and long-time girlfriend Regina Lasko. He began by asking if anyone else's weekend had flown by, through gritted teeth, and went on to say:

"...Right now I would give anything to be hiking on the Appalachian Trail. I got into the car this morning and the navigation lady wasn't speaking to me."

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