Drew Brees Birthmark: WATCH Oprah Mistake It For Lipstick, Attempt To Wipe It Off (VIDEO)

04/17/2010 05:12 am ET | Updated May 25, 2011

An awkward moment ensued Friday when Drew Brees' birthmark was exposed to Oprah Winfrey on her show and she attempted to wipe it off.

Oprah apparently thought the mark was lipstick, saying, "Who just kissed you?" while reaching her hand out to try to fix it.

But Brees has had the mole on his right cheek since birth.

WATCH THE AWKWARD OPRAH SEQUENCE INVOLVING DREW BREES' BIRTHMARK: