Well, if you're betting on Johnny Depp, the good news is that you've technically got a 40% chance of winning, as he's nominated twice in this category. Of course, one of those nominations is for 'The Tourist,' which both was not a comedy and, according to nearly every reviewer out there, not any good. But he did play the Mad Hatter in 'Alice In Wonderland,' which gives him a legit shot.
Also vying for the honor are naked Jake Gyllenhaal ('Love and Other Drugs'), thankfully not naked Paul Giamatti ('Red) and Kevin Spacey ('Casino Jack'), who aired disgraced lobbyist Jack Abramoff's dirty laundry on screen.
More:Golden Globe Golden Globe Winners Outstanding Actor Motion Picture Comedy Awards Season Who Will Win Golden Globes
HuffPost Entertainment is your one-stop shop for celebrity news, hilarious late-night bits, industry and awards coverage and more — sent right to your inbox six days a week. Learn more