Sheen, who called in to TMZ Live Thursday afternoon, said, "I'm tired of lying. I'm tired of pretending the show doesn't suck. I'm tired of pretending Ashton doesn't suck."
The actor, whose new show "Anger Management" was recently picked up by FX, went on to clarify, placing the blame on the show's writers. "It's nothing personal," he said. "I just feel bad for him. He's saddled with such bad writing."
The outburst comes just days after Warner Bros. lawyers representing the show's producers insisted Sheen cease using an old "Two and a Half Men" photo to promote his new comedy "Anger Management."
FX has ordered 10 initial episodes of the dark comedy, and as long as those episodes reach a certain ratings mark, Sheen's series will be greenlit for an unprecedented 90 additional episodes.
The former "Two and a Half Men" star, then the highest paid man on television, went off the rails following a winter 2011 drug binge, going on radio rants, co-habitating with two young "Goddesses" and throwing nasty words at his show's executive producer, Chuck Lorre.
Watch Sheen's call-in with TMZ Live, below.