PARIS -- Serena Williams' French Open is over after a first-round loss in mixed doubles to go with her quick exit in singles.

Playing together for the first time, Williams and Bob Bryan were beaten 7-5, 3-6, 10-6 by Gisela Dulko and Eduardo Schwank of Argentina at Roland Garros on Friday.

Williams was upset by 111th-ranked Virginie Razzano in singles on Tuesday, the American's only first-round loss in 47 Grand Slam tournaments.

She hadn't played mixed doubles at a major tournament since the 1999 Australian Open, when she and Max Mirnyi of Belarus lost in the final. Williams and Mirnyi won the 1998 Wimbledon and U.S. Open mixed doubles championships.

Her older sister Venus watched Friday's match from the stands and said: "Serena had some bad luck."