The daughters, Tallulah, Scout, and Rumer, cut off all contact after Tallulah's high school graduation when, RadarOnline reports, "None of the girls wanted Demi there but she turned up anyway and it was really strained. They had a huge fight afterward and the girls decided it would be in their best interests to take a break from Demi for a while."
Now several weeks later, a source tells RadarOnline Moore is "beside herself over the situation," and that she "hasn't spoken to Scout, Rumer or Tallulah... they won’t return any of her calls, emails or texts."
The source further describes Moore as "absolutely devastated ... and is trying to hold herself together, but this is a really tough time."
In addition to the rift between Demi and her kids, she's faced additional burdens after rumors flooded the Internet of nude photos of Moore's youngest daughter. The photos reportedly feature Tallulah Willis, Moore's child with actor Bruce Willis, topless and smoking what appears to be a joint.
Demi and Ashton Kutcher divorced in November 2011 after Kutcher cheated on her with a 22-year-old on their 6th wedding anniversary.
Afterward, the 49-year-old actress reportedly began using a dangerous cocktail of Aderall, Red Bull, and nitrous oxide (aka "whip-its"), culminating in a seizure and a trip to the hospital in January.
Though she attended rehab, Entertainment Wise reports her daughters fear Demi's potential for a relapse.
Earlier on HuffPost:
More:Demi Moore Breaking Point Demi Moore Demi Moore Kids Cut Ties Daughters Cut Ties To Demi Moore Demi Moore Family Troubles
HuffPost Entertainment is your one-stop shop for celebrity news, hilarious late-night bits, industry and awards coverage and more — sent right to your inbox six days a week. Learn more