It's dark days for House Lannister.

On Wednesday, TMZ learned that "Game of Thrones" actress Lena Headey filed to divorce musician Peter Loughran after five years of marriage. The British actress, who plays conniving queen Cersei Lannister on the HBO fantasy hit, cited "irreconcilable differences" as the cause of the split. The couple have one son, two-year-old Wylie Elliot.

Headey, 38, isn't the first HBO star to make headlines for splitting. Here are seven others, including one of Headey's co-stars on "Game of Thrones."

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  • Kim Cattrall

    "Sex and the City" star Kim Cattrall ended her third marriage, to audio designer Mark Levinson, <a href="http://www.dailymail.co.uk/tvshowbiz/article-2151569/Revealed-Cougar-Kim-Cattrall-55-puts-toyboys-date-extraordinarily-wealthy-artist-Clifford-Ross-60.html#ixzz21lETNZQA" target="_hplink"> in 2004 after six years together.</a> She'd previously been married to <a href="http://www.usmagazine.com/celebrities/kim-cattrall#ixzz21lkmz" target="_hplink">Larry Davis (before getting an annulment in 1979) and then to Andre Lyson</a>, whom she divorced in 1989. In an <a href="http://www.more.com/news/womens-issues/kim-cattrall-goes-it-alone" target="_hplink">interview with <em>More</em></a> after her divorce from Levinson, Cattrall said she had developed an outlook on dating that would surely make Samantha, her "Sex and the City" character, proud. "In my 20s and 30s, I was a serial monogamist. But now, in my late 40s, I'm going to swing, in the sense that I'm going to lead my life in a way I never have before."

  • James Gandolfini

    On the "Sopranos," James Gandolfini <a href="http://www.hbo.com/the-sopranos/cast-and-crew/index.html" target="_hplink">played mob boss Tony Soprano</a>, a man whose marriage to long-suffering wife Carmela was shaky, at best. In real life, the actor has been married twice. In December 2002, his first wife, Marcella (Marcy) Gandolfini, <a href="http://www.people.com/people/article/0,,625340,00.html" target="_hplink">filed for divorce on the grounds of abandonment</a> after three years of marriage. The couple have a son together. In August 2008, the 50-year-old <a href="http://www.people.com/people/article/0,,20222704,00.html" target="_hplink">wed former model Deborah Lin</a> in her hometown of Honolulu, Hawaii, after two years of dating.

  • Sean Bean

    Sean Bean, who played family patriarch Ned Stark on <a href="http://www.hbo.com/game-of-thrones/index.html" target="_hplink">"Game of Thrones,"</a> announced in December 2010 that he and fourth wife Georgina Sutcliffe had <a href="http://www.dailymail.co.uk/tvshowbiz/article-1379208/Four-times-divorced-Sean-Bean-says-given-marriage.html" target="_hplink">divorced after four years of marriage</a>. After the divorce, Bean -- who was <a href=" Melanie Hill." target="_hplink">previously married</a> to hairdresser Debra James and actresses Melanie Hill and Abigail Cruttenden -- admitted he wasn't sure if he had what it takes to stay married. "Of course I believe in love despite four divorces. There is nobody who doesn't believe in love," <a href="http://www.dailymail.co.uk/tvshowbiz/article-1379208/Four-times-divorced-Sean-Bean-says-given-marriage.html" target="_hplink">the 53-year-old actor told Croatian magazine <em>Gloria</em></a>. "But marriage -- that fits some people but obviously not me."

  • Larry David

    On <a href="http://www.hbo.com/curb-your-enthusiasm/index.html" target="_hplink">"Curb Your Enthusiasm,"</a> Larry David's fictional wife, Cheryl, suffered through seven seasons of marriage to David's fictionalized, highly neurotic version of himself, before finally filing for divorcing in the season eight premiere. Off-camera, David and his real wife, Laurie, <a href="http://www.people.com/people/article/0,,20041420,00.html" target="_hplink">separated in June 2007</a> after 14 years of marriage. After the divorce, the couple made a point to continue to share family dinners with their two daughters -- an experience which Laurie <a href="http://www.huffingtonpost.com/laurie-david/my-family-dinner-after-di_b_779277.html" target="_hplink">wrote about in a HuffPost blog</a>.

  • Louis CK

    Before he was <a href="http://www.huffingtonpost.com/2012/07/19/louis-ck-emmy-nominations_n_1687227.html" target="_hplink">scoring record-breaking Emmy nominations</a> for his <a href="http://www.fxnetworks.com/louie/" target="_hplink">FX comedy, "Louie,"</a> comedian Louie CK starred in a short-lived <a href="http://www.imdb.com/title/tt0460619/" target="_hplink">HBO show, "Lucky Louie,"</a> in 2006. After the show ended, the comedian divorced his wife, painter <a href="http://screeninvasion.com/2012/07/louie-daddys-girlfriend-pt-1-episode-recap/#.UBGZiDHLyRl" target="_hplink">Alix Bailey, in 2008</a>. The couple <a href="http://www.gq.com/entertainment/movies-and-tv/201108/louis-ck-interview-gq-august-2011#ixzz21l4AiryC" target="_hplink">now share custody</a> of their two daughters. On <a href="http://www.fxnetworks.com/louie/" target="_hplink"> "Louie,"</a> the comedian sticks to what he knows, <a href="http://www.huffingtonpost.com/2012/06/13/fathers-day-divorced_n_1588335.html#slide=1083053" target="_hplink">portraying a divorced standup comedian</a> raising two daughters.

  • Laura Dern

    Laura Dern, who plays a woman recovering from a nervous breakdown on <a href="http://www.hbo.com/enlightened/index.html" target="_hplink">"Enlightened,"</a> filed to <a href="http://www.hollywoodreporter.com/news/laura-dern-ben-harper-divorce-346393" target="_hplink">divorce husband Ben Harper in early July</a>. Previous reports suggested that the couple may have <a href="http://www.huffingtonpost.com/2012/02/07/ben-harper-reconciling_n_1260286.html#s217664&title=Stephanie_Seymour_and" target="_hplink">tried to reconcile</a> before finally calling it quits. Dern and Harper have two children, <a href="http://www.hollywoodreporter.com/news/laura-dern-ben-harper-divorce-346393" target="_hplink">10-year-old Ellery, and 7-year-old Jaya</a>.

  • Ian McShane

    On "Deadwood," Ian McShane portrayed salty saloon owner and anti-hero Al Swearengen. In real-life, the British actor has been married three times. His <a href="http://www.telegraph.co.uk/culture/film/starsandstories/3654091/The-monster-who-changed-my-life.html" target="_hplink">first marriage, to Suzanne Farmer, ended in 1965</a> after two years. His second marriage, to model Ruth Post, reportedly ended in 1976 when he <a href="http://www.telegraph.co.uk/culture/film/starsandstories/3654091/The-monster-who-changed-my-life.html" target="_hplink">ran off with Sylvia Kristel,</a> the soft-porn star of the "Emmanuelle" films. McShane, who eventually parted ways with Kristel, <a href="http://www.telegraph.co.uk/culture/film/starsandstories/3654091/The-monster-who-changed-my-life.html" target="_hplink">married American actress Gwen Humble</a> in 1980. "I can't remember the first two marriages," <a href="http://www.telegraph.co.uk/culture/film/starsandstories/3654091/The-monster-who-changed-my-life.html" target="_hplink">he told <em>The Telegraph</em> in July 2006</a>. "I've been married 27 years to the same woman and it's third time lucky."

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