WASHINGTON -- Sen. Claire McCaskill (D-Mo.) warned top Republican officials on Monday that any efforts to push Rep. Todd Akin (R-Mo.) out of the Senate race against her, following his galling remarks about "legitimate" rape victims not getting pregnant, would backfire.

"I think for Washington party insiders to come in and try to invalidate the votes of Missourians would be radical," McCaskill said in a phone interview with The Huffington Post. "I think that would be a very radical thing to have happen, and I can't imagine how the Republican primary voters would think about that in Missouri."

"I think there would be a significant backlash," she added. "I'm not sure that would have a good ending for the Republican Party."

The comments were some of the first McCaskill has made in the wake of Akin's interview with KTVI-TV, in which he said that doctors had told him it was rare for rape to result in pregnancy.

"If it's a legitimate rape, the female body has ways to try to shut that whole thing down," said Akin, who was explaining the basis of his rigid pro-life stance. "But let's assume maybe that didn't work or something. I think there should be some punishment, but the punishment ought to be on the rapist."

On Sunday night, Akin said he had misspoken, but did not disavow his remarks or explain where he had received the information on which they were based. By Monday morning, top Republican officials were calling on him to resign, with strategist Mike Murphy summarizing the sentiment in a tweet: "Akin should put good of GOP first and resign nomination now after his idiotic comment. Senate control too important."

McCaskill challenged Akin to name a doctor who would actually back up his claim, saying his comments were born from a deep ignorance of women's issues.

"I have a hard time imagining a woman uttering the phrase 'legitimate rape,'" McCaskill said. "It is not something that would ever come out of a woman's mouth, because it is something every woman is fearful of. I think every woman knows someone who has had to deal with sexual assault."

McCaskill noted that she herself dealt with rape cases as a former prosecutor.

"I think if you've never been afraid of being raped, if it is never been anything you've worried about, then maybe you just don't think clearly about it," she said. "If you have any sense of how women's anatomy works, it would be hard to justify the ignorance he showed by claiming that a doctor told him that."

The senator, who trailed Akin in polls prior to the incident, said she has had a "robust" response to the controversy her opponent's comments sparked. She was initially alerted to them via an email from her staff Sunday and spent the rest of the day responding to emails and press requests.

The fallout has since moved beyond the confines of the Show Me State, becoming national news that has led to statements of rebuke from Senate candidates and even the Republican presidential ticket. The Democratic National Committee on Monday morning sent out an email attempting to tie Mitt Romney and Rep. Paul Ryan (R-Wis.) to the issue, pointing out that "Ryan was one of more than 200 Republican cosponsors of a piece of legislation that would have narrowed the definition of rape."

McCaskill argued that Akin's statement was symptomatic of a larger GOP insensitivity toward women's health.

"Obviously, you look at the personhood amendment that both Todd Akin and Paul Ryan cosponsored," she said. "That goes much farther than most people realize. This is beyond just their desire to overturn Roe v. Wade, this is a desire to go further. It is refighting the contraception wars that my 84-year old mother fought.

"I was sitting with and visiting her the other day," McCaskill said. "She said, 'Sorry honey.' I said, 'What are you sorry about?' She said, 'I thought we took care of this. I thought we won.' ... I think that some people in the Republican Party, including Congressman Akin, would like to take us back to that age."

Also on HuffPost:

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  • Gov. Jan Brewer (R-Ariz.)

    "Well, I thought his comments were a little bit outrageous," she <a href="http://www.kjzz.org/content/1208/gov-brewer-akin-comments-little-bit-outrageous-doesnt-call-candidate-drop-out-race" target="_hplink">told KJZZ's Mark Brodie</a>. "I'm not in a position to [decide] whether it's right for the party to pull funding, I mean, those people there raise the money, they get to spend it however they wish."

  • Mitt Romney

    "As I said yesterday, Todd Akin's comments were offensive and wrong and he should very seriously consider what course would be in the best interest of our country," said Romney in a statement. "Today, his fellow Missourians urged him to step aside, and I think he should accept their counsel and exit the Senate race." Earlier, from an <a href="http://www.nationalreview.com/corner/314452/romney-akins-inexcusable-comment-robert-costa" target="_hplink">interview with the National Review</a>: <blockquote>"Congressman's Akin comments on rape are insulting, inexcusable, and, frankly, wrong," Romney said. "Like millions of other Americans, we found them to be offensive."</blockquote>

  • Gov. Chris Christie (R-N.J.)

    "He should be ashamed of himself to be talking about it in that way," Christie said. "It's stunning to me that somebody who's offering themselves for high office like that would have those kind of thoughts and use that kind of language."

  • Gov. Scott Walker (R-Wis.)

    From <a href="http://mountpleasant.patch.com/articles/gov-scott-walker-says-missouri-senate-candidate-todd-akin-should-get-out" target="_hplink">Patch</a>: <blockquote>Gov. Scott Walker said Tuesday that Republican Missouri Senate candidate Todd Akin should drop out of the race after Akin made controversial comments about rape and pregnancy. "Yes, he should step down. Those comments were ignorant at best and outrageous," Walker said during a ribbon-cutting ceremony in Sturtevant.</blockquote>

  • Gov. Bob McDonnell (R-Va.)

    "He's got to seriously decide what's in the best interest of the party, what's in the best interest of the state of Missouri, and frankly, at this point, given that flat wrong statement, whether he can win," McDonnell <a href="http://www.huffingtonpost.com/2012/08/21/bob-mcdonnell-todd-akin_n_1818906.html?1345568504" target="_hplink">told The Huffington Post</a>. "I think there was a belief a month ago, when it was just he and [incumbent Sen. Claire] McCaskill head to head after he got the nomination, that it would be a hard-fought competitive race, with Romney at the top of the ticket and up double digits, that this would be a race that would be winnable for the Republicans," McDonnell said. "To say things that seemed to be so flat wrong and out of touch with both science and the people, I think it makes it very difficult at this point for him to win."

  • NRSC Chair Sen. John Cornyn (R-Texas)

  • Sen. Claire McCaskill (D-Mo.)

    "It is beyond comprehension that someone can be so ignorant about the emotional and physical trauma brought on by rape ... The ideas that Todd Akin has expressed about the serious crime of rape and the impact on its victims are offensive."

  • Mitt Romney/Paul Ryan Campaign

    "Gov. Romney and Congressman (Paul) Ryan disagree with Mr. Akin's statement, and a Romney-Ryan administration would not oppose abortion in instances of rape," Romney spokeswoman Amanda Henneberg said. "Congressman's Akin comments on rape are insulting, inexcusable, and, frankly, wrong," <a href="http://www.nationalreview.com/corner/314452/romney-akins-inexcusable-comment-robert-costa" target="_hplink">Romney said</a>. "Like millions of other Americans, we found them to be offensive."

  • Sen. Minority Leader Mitch McConnell (R-Ky.)

    "What he said is just flat wrong in addition to being wildly offensive to any victim of sexual abuse. Although Representative Akin has apologized, I believe he should take time with his family to consider whether this statement will prevent him from effectively representing our party in this critical election," said McConnell, according to the <a href="http://www.latimes.com/news/politics/la-pn-mcconnell-suggests-todd-akin-consider-his-options-20120820,0,5243455.story" target="_hplink"><em>Los Angeles Times</em></a>.

  • Minority Leader Nancy Pelosi (D-Calif.)

  • Sen. Lisa Murkowski (R-Alaska)

  • Elizabeth Warren

  • Sen. Scott Brown (R-Mass.)

    "As a husband and father of two young women, I found <a href="http://livewire.talkingpointsmemo.com/entry/scott-brown-calls-for-todd-akin-to-drop" target="_hplink">Todd Akin's comments</a> about women and rape outrageous, inappropriate and wrong. There is no place in our public discourse for this type of offensive thinking. Not only should he apologize, but I believe Rep. Akin's statement was so far out of bounds that he should resign the nomination for US Senate in Missouri."

  • Rep. Steve King (R-Iowa)

    "Whether he has mispoken or whether he has a position that we would have trouble agreeing on, I don't know that. I do know him and I do know his family, and I'm impressed with what they've accomplished. So that's the best I can do with what little bit I know," <a href="http://www.youtube.com/watch?v=LDsQkjnQx5Y&feature=youtu.be" target="_hplink">said King</a>. And later: "I just haven't heard of that being a circumstance that's been brought to me in any personal way," he <a href="http://www.kmeg14.com/story/19324372/rep-steve-king-on-the-campaign-trail" target="_hplink">told KMEG</a>. "I'd be open to hearing discussion about that subject matter."

  • Sen. Kelly Ayotte (R-N.H.)

  • Rep. Chris Van Hollen (D-Md.)

    "I have to agree with those, including Republicans, who have said he should give up his race for Senate," said Van Hollen on <a href="http://video.msnbc.msn.com/newsnation/48728017/#48728017" target="_hplink">NewsNation with Tamron Hall</a>.

  • Rep. Connie Mack (R-Fla.)

    "Like Joe Biden's comments last week, I find Todd Akin's comments made Sunday to be just as outrageous and offensive. Such insulting and offensive remarks from Joe Biden and Todd Akin have no place in our political discourse," said Mack in a <a href="http://miamiherald.typepad.com/nakedpolitics/2012/08/connie-mack-cosponsor-of-forcible-rape-bill-links-akins-legitimate-rape-with-bidens-chains-.html" target="_hplink">press release</a>.

  • Sen. Ron Johnson (R-Wis.)

  • Cindy McCain

  • Former Sen. Jim Talent (R-Mo.)

    Talent, who once held the Senate seat Akin is running for, declined to endorse Akin on Monday. "It's a decision he has to make," Talent said when asked whether Akin should step aside, according to the <a href="http://www.latimes.com/news/politics/la-pn-todd-akin-stay-in-senate-race-20120820,0,2849040.story" target="_hplink"><em>Los Angeles Times</em></a>. "I can't agree with anything [Akin] said," Talent later clarified.

  • Rep. Debbie Wasserman Schultz (D-Fla.)

    "Now, Akin's choice of words isn't the real issue here. The <a href="http://www.politico.com/blogs/burns-haberman/2012/08/dnc-email-ties-romney-to-todd-akin-132522.html" target="_hplink">real issue</a> is a Republican party -- led by Mitt Romney and Paul Ryan -- whose policies on women and their health are dangerously wrong. I'm outraged at the Republicans trying to take women back to the dark ages -- if you agree, join me in taking a stand for women. Really, it's deeply concerning that Republicans continue to support legislation that is, quite literally, dangerous for women. Mitt Romney famously says he would "get rid of" federal funding for Planned Parenthood if he had the chance. His running mate, Paul Ryan, was one of more than 200 Republican cosponsors of a piece of legislation that would have narrowed the definition of rape. Can you imagine -- the same Republican House that refuses to pass a jobs bill jumped at the opportunity to make life harder for victims of rape? And what do Romney and Ryan think of Akin's latest statement? They've been trying to distance themselves from it -- but Congressman Ryan has already partnered with Akin on a whole host of issues that restrict women's ability to make their own health care decisions."

  • Sarah Steelman, Akin's Former Primary Opponent

  • Meghan McCain

  • Terry O'Neill, President Of The National Organization For Women

    "That kind of rhetoric re-traumatizes sexual assault victims. ... That kind of talk, I believe, is intended to shame women," she told the <a href="http://www.huffingtonpost.com/2012/08/20/todd-akin-rape-comments_n_1810362.html?1345468189" target="_hplink">Associated Press radio</a>, characterizing the remarks as "flat-out astonishing."

  • Mike Murphy, GOP Consultant

  • Michelle Malkin, Conservative Columnist

  • Joe Scarborough, Host Of MSNBC's "Morning Joe"

    "There is a rule," <a href="http://www.mediaite.com/tv/scarborough-reacts-to-akins-rape-remark-conservatives-neglecting-to-choose-the-most-electable-candidate/" target="_hplink">he [Scarborough] continued</a>, "that we conservatives have followed for a long time, and it's the 'Bill Buckley Rule.' You elect the most electable conservative. The person who is the most conservative and who is the most electable is the one you put on the ticket. That's the part of the equation that we're losing over the last three years. And it's making Harry Reid the majority leader."

  • Bryan Fischer, Conservative Radio Host

  • Tom Perriello, President Of Center For American Progress Action Fund

  • Petition By The Democratic Congressional Campaign Committee

    <blockquote><a href="http://dccc.org/pages/denounce-todd-akin?source=2012.08.20_kw_all" target="_hplink">Sign your name to call</a> on Speaker John Boehner to remove Rep. Todd Akin from the House Science and Technology Committee. Republican Congressman Todd Akin told a Missouri news station: "First of all, from what I understand from doctors [pregnancy from rape] is really rare... If it's a legitimate rape, the female body has ways to try to shut that whole thing down." Someone who believes nonsense like this has no part overseeing science policy. Tell Speaker Boehner to immediately remove Rep. Akin from the House Science and Technology Committee.</blockquote>

  • Susan B. Anthony List

    <blockquote>"Congressman Akin, a longtime pro-life leader, has said he had misspoken, and no one is arguing that rape is anything but a despicable, horrible crime. "Abortion supporters like Sen. Claire McCaskill are trying to use this issue as a smokescreen to hide from their radical, pro-abortion records that are out of step with the majority of Missourians and the American people. On the issues of taxpayer funding of elective abortion in Obamacare, protection of unborn girls being targeted in the womb solely because of their gender, and whether children capable of feeling pain in the womb should be protected, President Obama and Senator McCaskill have been on the wrong side, showing that they favor abortion on-demand, for any reason, up to the moment of birth, subsidized by the taxpayers. "If President Obama and Senator McCaskill care to focus on extreme positions, it is time for self reflection. It is time to answer the question why this president has recently rejected bans on gender selection and late term abortions. "Todd Akin, on the other hand, has a record of voting to protect human life. His opponent does not. Congressman Akin has been an excellent partner in the fight for the unborn."</blockquote>

  • Tea Party Express

    <a href="http://www.teapartyexpress.org/5205/tea-party-express-urges-rep-akin-to-step-down" target="_hplink">Tea Party Express</a>, the nation's largest tea party political action committee, is urging Congressman Todd Akin to resign his candidacy for the U.S. Senate. Tea Party Express Chairman Amy Kremer said, "Congressman Akin's comments this weekend are not just unfortunate and inappropriate, but they are distracting from our main goal of defeating Claire McCaskill and taking the Senate gavel out of the hands of Harry Reid. At a time when our national debt is approaching $16 trillion, job growth is stagnate, and the Senate has failed to pass a budget in over 3 years, we need a candidate that is ready to help lead the charge for conservative solutions. "One of the lessons we learned in 2010 is that we need candidates who are not only conservative, but are capable of putting together a strong campaign against liberal opponents. Akin's frequent 'Bidenisms' are distracting from the important issues at hand. "It is critical that we defeat Senator Claire McCaskill in November, but it will be too difficult to achieve that with Todd Akin as the conservative alternative. He should step down and give conservatives a chance at taking back the Senate in November," Kremer concluded.