NEW YORK -- Venus Williams overcame an early deficit for an easy win in her return to the U.S. Open.

The seven-time Grand Slam champion pulled out of the tournament before her second-round match last year because of an autoimmune disease. Williams was back Tuesday, and she beat fellow American Bethanie Mattek-Sands 6-3, 6-1.

Williams, unseeded with a ranking of No. 46, was broken in her first game. But after going down 0-2 in the first set, she won 12 of the last 14 games.

She'll next face sixth-seeded Angelique Kerber.

Mattek-Sands is ranked 212th after a series of injuries this year and got in on a wild card.

At age 32, Williams has been learning to deal with the effects of Sjogren's syndrome, which causes exhaustion and joint pain.

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  • Agnieszka Radwanska

    Agnieszka Radwanska, of Poland, returns a shot to Nina Bratchikova, of Russia, at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Agnieszka Radwanska

    Agnieszka Radwanska, of Poland, returns a shot to Nina Bratchikova, of Russia, at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Agnieszka Radwanska

    Agnieszka Radwanska, of Poland, returns a shot to Nina Bratchikova, of Russia, at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Nina Bratchikova

    Nina Bratchikova, of Russia, serves to Agnieszka Radwanska, of Poland, during the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Ryuichi Sakamoto

    Japanese musician Ryuichi Sakamoto plays the piano at the U.S. ambassador's residence in Tokyo Tuesday, Aug. 28, 2012, as he unveils a piece of music he composed specially to mark the opening of the Metropolitan Museum of Art exhibition in Tokyo this fall.

  • Ana Ivanovic

    Serbia's Ana Ivanovic serves to Ukraine's Elina Svitolina in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Ana Ivanovic

    Serbia's Ana Ivanovic serves to Ukraine's Elina Svitolina in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Agnieszka Radwanska

    Agnieszka Radwanska of Poland against Nina Bratchikova of Russia during their women's first round 2012 US Open match at the USTA Billie Jean King National Tennis Center in New York on August 28, 2012.

  • Elina Svitolina

    Ukraine's Elina Svitolina returns a shot to Agnieszka Radwanska, of Poland, in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Elina Svitolina

    Ukraine's Elina Svitolina serves to Agnieszka Radwanska, of Poland, in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Ana Ivanovic

    Serbia's Ana Ivanovic returns a shot to Ukraine's Elina Svitolina in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Elina Svitolina

    Elina Svitolina of the Ukraine reacts during her match against Serbia's Ana Ivanovic in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Elina Svitolina

    Elina Svitolina of the Ukraine returns a shot to Serbia's Ana Ivanovic in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Tomas Berdych

    Tomas Berdych serves to David Goffin, of Belgium, in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • David Goffin

    Belgium's David Goffin returns a shot to Czech Republic's Tomas Berdych in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • David Goffin

    David Goffin, of Belgium, wipes his face while playing Czech Republic's Tomas Berdych in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Peng Shuai

    China's Peng Shuai serves to Elena Vesnina, of Russia, in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Peng Shuai

    China's Peng Shuai reacts during her match against Elena Vesnina, of Russia, in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Elena Vesnina

    Elena Vesnina, of Russia, returns a shot to China's Peng Shuai in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Jimmy Wang

    Taiwan's Jimmy Wang returns a shot to Croatia's Ivo Karlovic in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Jimmy Wang

    Taiwan's Jimmy Wang serves to Croatia's Ivo Karlovic in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Ana Ivanovic

    Serbia's Ana Ivanovic reacts during her match against Ukraine's Elina Svitolina in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Ivo Karlovic

    Croatia's Ivo Karlovic returns a shot to Taiwan's Jimmy Wang in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Elina Svitolina

    Ukraine's Elina Svitolina reacts in the first round of play against Serbia's Ana Ivanovic at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Ana Ivanovic

    Serbia's Ana Ivanovic signs autographs afer her match against Ukraine's Elina Svitolina in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Ivo Karlovic

    Croatia's Ivo Karlovic serves to Taiwan's Jimmy Wang in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Andy Roddick

    Andy Roddick returns a shot to Rhyne Williams at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Rhyne Williams

    Rhyne Williams returns a shot to Andy Roddick during the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Jo-Wilifried Tsonga

    Jo-Wilifried Tsonga of France returns a shot to Slovakia's Karol Beck in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Andy Roddick

    Andy Roddick returns a shot to Rhyne Williams in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Andy Roddick

    Andy Roddick serves to Rhyne Williams in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • David Goffin

    Belgium's David Goffin returns a shot to Czech Republic's Tomas Berdych in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Andy Roddick

    Andy Roddick returns a shot to Rhyne Williams in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Milos Raonic

    Canada's Milos Raonic returns a shot to Colombia's Santiago Giraldo in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Santiago Giraldo

    Colombia's Santiago Giraldo returns a shot to Canada's Milos Raonic in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Milos Raonic

    Canada's Milos Raonic reacts during a match against Colombia's Santiago Giraldo in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • US Open

    Fans watch a match during the first round of play at the Grandstand stadium during the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Jo-Wilifried Tsonga

    Jo-Wilifried Tsonga returns a shot to Slovakia's Karol Beck in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.

  • Jo-Wilifried Tsonga

    France's Jo-Wilfried Tsonga returns a shot to Slovakia's Karol Beck in the first round of play at the 2012 US Open tennis tournament, Tuesday, Aug. 28, 2012, in New York.