There were a number of extraordinary moments during Comedy Central's Night Of Too Many Stars benefit for autism programs, but there was one in particular that drew tears from the audience rather than laughs.

The theme for the night was bringing together unlikely couples: Bill O'Reilly and Chris Matthews, Harvey Keitel and Carly Rae Jepson, Paula Dean and butter (well, unlikely now). But the most unexpected of them all was little Jodi DiPiazza, a young girl living with autism, and superstar Katy Perry. In a pre-taped profile on DiPiazza, the audience learned of her struggles with the disorder as well as how she began to find a way forward through music.

Following the video, DiPiazza, seated almost comically at an enormous grand piano, was joined on stage by Katy Perry for a duet of the star's hit song, "Firework." What followed was a performance that left not one dry eye in the theater.

Perry tweeted later that night:


Jon Stewart, MC for the evening, was so overcome by the moment he had to take a few seconds to recover himself, eliciting even more applause from the enraptured audience who seemed to feel exactly the same way.

Watch the video above to see for yourself how Jodi and Katy brought the house down, and make sure to tune in for the Night Of Too Many Stars on Sunday, October 21 at 8:00 ET.

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  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Katy Perry performs onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Katy Perry performs onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Katy Perry performs onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Jon Stewart speaks onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13 Ben Stiller and Tommy Hilfiger speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City(Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Chris Matthews and Bill O'Reilly speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: (L-R) Chris Matthews, John King and Bill O'Reilly speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Seth Rogen and Jon Stewart speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Harvey Keitel and Carly Rae Jepsen perform onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Harvey Keitel speaks onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Harvey Keitel and Carly Rae Jepsen perform onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Harvey Keitel and Carly Rae Jepsen perform onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Comedian Hannibal Buress speaks onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Stephen Colbert speaks onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Tom Morello performs onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: (L-R) Tina Fey, Amy Poehler and Jon Stewart speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Tina Fey, Amy Poehler and Jon Stewart speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Tina Fey and Amy Poehler speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: (L-R) Steve Schirripa, Jenni 'J Woww' Farley and Sammi 'Sweetheart' Giancola speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: J.B. Smoove (R) speaks onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Louis C.K. speaks onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Kevin Bacon and Paula Deen speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Kevin Bacon, Liev Schreiber and Paula Deen perform onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Paula Deen, Kevin Bacon and Liev Schreiber perform onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Bill Burr speaks onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Sting (R) speaks onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Sting (L) performs onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: (L-R) Jon Stewart, Tom Morello, Hannibal Buress, Louis C.K., Seth Rogen and Bill Burr pose onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Singer Katy Perry (L) and Carly Rae Jepsen (R) pose onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Katy Perry, Carly Rae Jepsen, Harvey Keitel, Sting and J.B. Smoove perform onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: Katy Perry, Carly Rae Jepsen, Harvey Keitel, Sting and J.B. Smoove speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)

  • Comedy Central's Night Of Too Many Stars: America Comes Together For Autism Programs - Show

    NEW YORK, NY - OCTOBER 13: (L-R) Jon Stewart, Tom Morello, Hannibal Buress, Louis C.K., Seth Rogen, Bill Burr, Steve Schirripa, Katy Perry, Carly Rae Jepsen, Harvey Keitel, Sting and JB Smooth speak onstage at Comedy Central's night of too many stars: America comes together for autism programs at The Beacon Theatre on October 13, 2012 in New York City. (Photo by Dimitrios Kambouris/Getty Images)