LAS VEGAS -- No need for Juan Manuel Marquez to impress the judges. No need for the referee to count to 10.

Marquez took care of all of his business Saturday night with a thunderous right hand that left Manny Pacquiao face first on the canvas with his remarkable career in question.

Unable to win a decision in their first three fights, Marquez won the old-fashioned way with a huge right hand that put Pacquiao down for the second time in the fight at 2:59 of the sixth round.

Referee Kenny Bayless never bothered to count as Marquez leaped into his handlers' arms in celebration and Pacquiao's wife broke into tears at ringside.

"I threw a perfect punch," Marquez said. "I knew Manny could knock me out at any time."

It was a stunning end to a thrilling fight, the fourth one in the last eight years between the two men. It could also be the end of the Filipino's career, though he said in the ring afterward he would like to fight Marquez for a fifth time.

"If you give us a chance, we'll fight again," Pacquiao said. "I was just starting to feel confident and then I got careless."

Pacquiao had been down in the third round but knocked Marquez down in the fifth and the two were exchanging heavy blows in the sixth round before Marquez threw a right hand that flattened Pacquiao face down on the canvas.

"I thought I was getting him in the last couple of rounds but I got hit by a strong punch," Pacquiao said. "I never expected that punch."


STORY CONTINUES BELOW


Pacquiao was down for about two minutes before his handlers managed to get him up as Marquez celebrated and the sold-out crowd at the MGM erupted.

After being helped to his corner, Pacquiao sat on a stool, blew his nose and stared vacantly ahead as his handlers cut his gloves off. It was a stunning end to a furious fight, and Pacquiao was later taken to a hospital for precautionary examination.

"We always worked on that punch," Marquez said. "We knew he was going to come out aggressive so we had a fight plan that was more technical. We were able to capitalize on it."

Marquez had vowed to finally beat Pacquiao after losing two close fights and settling for a draw in the first fight. But after Pacquiao knocked him down in the fifth round and was landing big left hands, it looked like it would be Pacquiao's night.

The two came out for the sixth round and the pace was just as relentless. Both were landing big punches and both were brawling when suddenly as the round came to close Marquez shot out a right hand that landed flush to the jaw of Pacquiao, who crumpled to the canvas in a heap.

"I felt he was coming to knock me out the last three rounds and I knew he was going to be wide open," Marquez said.

It was the second loss in a row for Pacquiao, who dropped a decision to Timothy Bradley in June and who had vowed to regain his prominence in the ring.

Pacquiao was aggressive from the opening bell, but paid the price in the third round when he got caught by a Marquez right hand that put him down. Pacquiao got back up and seemingly took control of the fight, dropping Marquez in the fifth round and landing the bigger punches until he was dropped.

"I got hit by a punch I didn't see," Pacquiao said.

Pacquiao, who earned more than $20 million for the fight, was ahead 47-46 on all three scorecards after the fifth round.

There was no title at stake in the 147-pound fight, but that didn't stop 16,348 fans from filling the MGM Grand Arena and roaring in unison from the opening bell as the two fighters went after each other.

Ringside punching stats underscored the ferocity of the bout, showing Pacquiao landing 94 of 256 punches to 52 of 246 for Marquez. But it was the one big right hand from Marquez that counted more than anything, knocking Pacquiao out for the first time in a career that goes back 17 years.

"He was in charge," Pacquiao's trainer, Freddie Roach said. "He just got a little too careless and got hit with a punch he didn't see."

Promoter Bob Arum immediately said he could see a fifth fight between the two boxers, and a dazed Pacquiao seemed to agree.

"Why not?" he said.

Pacquiao weighed the class limit of 147 pounds, but it was Marquez who looked like the stronger fighter entering the ring after having bulked up with the help of a strength conditioner, though he weighed in at 143 pounds. In their earlier fights, Pacquiao had been the bigger puncher, knocking Marquez down a total of four times, but on this night it was Marquez who had the biggest punch.

The stunning knockout was the first real loss by Pacquiao in seven years. He lost a close decision to Bradley in his last fight, but most ringside observers believed he had won it fairly convincingly.

Marquez improved to 55-6-1 with 40 knockouts, while Pacquiao fell to 54-5-2.

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  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, stands over Manny Pacquiao, from the Philippines, after knocking him down in the third round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico celebrates his win over Manny Pacquiao in their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Juan Manuel Marquez, Kenny Bayless

    Juan Manuel Marquez, from Mexico, wears the champion's belt as his fist is raised by referee Kenny Bayless after his sixth round knockout of Manny Pacquiao, from the Philippines, in their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, celebrates his win over Manny Pacquiao in their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, and Manny Pacquiao, from the Philippines, trade blows during their WBO world welterweight fight Sunday, Dec. 9, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez, Kenny Bayless

    Referee Kenny Bayless, left, calls the fight as Juan Manuel Marquez, from Mexico, right, rushes from his corner after knocking out Manny Pacquiao, from the Philippines, left, in the sixth inning of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Marquez won the fight by a knockout. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez, Kenny Bayless

    Referee Kenny Bayless, center, sends Juan Manuel Marquez, from Mexico, right, to his corner after Marquez knocked out Manny Pacquiao, from the Philippines, left, in the sixth inning of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Marquez won the fight by a knockout. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, right, knocks out Manny Pacquiao, from the Philippines, in the sixth round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez, Kenny Bayless

    Juan Manuel Marquez, from Mexico, right, connects against Manny Pacquiao, from the Philippines, as referee Kenny Bayless looks on at left, during their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Marquez won the fight by a knockout. (AP Photo/Julie Jacobson)

  • Manny Pacquiao, Juan Manuel Marquez

    Manny Pacquiao, from the Philippines, left, sends Juan Manuel Marquez, from Mexico, to the mat in the fifth round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Marquez went on to win the bout by a knockout. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez, Kenny Bayless

    Juan Manuel Marquez, from Mexico, right, and Manny Pacquiao, from the Philippines, trade blows during their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Marquez won the fight by a knockout. Referee Kenny Bayless looks on at left. (AP Photo/Julie Jacobson)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, right, lands a right to the head of Manny Pacquiao, from the Philippines, during their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Marquez won by a knockout. (AP Photo/Julie Jacobson)

  • Manny Pacquiao, Juan Manuel Marquez

    Manny Pacquiao, from the Philippines, connects against Juan Manuel Marquez, from Mexico, during their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Marquez won by a knockout. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Kenny Bayless

    Manny Pacquiao, from the Philippines, lifts himself from the canvas as referee Kenny Bayless stands by after being knocked down in the third round of his WBO world welterweight fight against Juan Manuel Marquez, from Mexico, Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, lands a left against Manny Pacquiao, from the Philippines, during their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Marquez won the fight by a knockout. (AP Photo/Eric Jamison)

  • Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, celebrates his win over Manny Pacquiao in their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, celebrates his win over Manny Pacquiao in their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Manny Pacquiao, from the Philippines, right, stands in the ring with Juan Manuel Marquez, from Mexico, after losing by a knockout in their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Freddie Roach

    Trainer Freddie Roach stands in the ring after his fighter, Manny Pacquiao, from the Philippines, lost to Juan Manuel Marquez, from Mexico, by a knockout in their WBO world welterweight fight Sunday, Dec. 9, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, celebrates his sixth round knockout victory over Manny Pacquiao, from the Philippines, in their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, celebrates his sixth round knockout victory over Manny Pacquiao, from the Philippines, in their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Kenny Bayless

    Referee Kenny Bayless calls the fight as he kneels over Manny Pacquiao, from the Philippines, after he was knocked out by Juan Manuel Marquez, from Mexico, during their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Manny Pacquiao, Juan Manuel Marquez, Kenny Bayless

    Referee Kenny Bayless, left, calls the fight as Juan Manuel Marquez, from Mexico, right, celebrates after he knocked out Manny Pacquiao, from the Philippines, lower left, in the sixth round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez, Kenny Bayless

    Referee Kenny Bayless, center, sends Juan Manuel Marquez, from Mexico, right, to his corner after he knocked out Manny Pacquiao, from the Philippines, left in the sixth round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Kenny Bayless

    Manny Pacquiao, from the Philippines, lies on the canvas as referee Kenny Bayless kneels nearby after being knocked out by Juan Manuel Marquez, from Mexico, in the sixth round of their WBO world welterweight fight Sunday, Dec. 9, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, right, knocks out Manny Pacquiao, from the Philippines, in the sixth round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, right, knocks out Manny Pacquiao, from the Philippines, in the sixth round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez, Kenny Bayless

    Juan Manuel Marquez, from Mexico, right, celebrates after knocking out Manny Pacquiao, from the Philippines, lower left, in the sixth round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Referee Kenny Bayless tends to Pacquiao. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez, Kenny Bayless

    Juan Manuel Marquez, from Mexico, left, celebrates after knocking out Manny Pacquiao, from the Philippines, in the sixth round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. Referee Kenny Bayless tends to Pacquiao at right. (AP Photo/Julie Jacobson)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, and Manny Pacquiao, from the Philippines, trade blows during their WBO world welterweight fight Sunday, Dec. 9, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Kenny Bayless

    Manny Pacquiao, from the Philippines, lifts his trunks after being knocked down in the third round of his WBO world welterweight fight against Juan Manuel Marquez, from Mexico, Saturday, Dec. 8, 2012, in Las Vegas. Referee Kenny Bayless looks on at left. (AP Photo/Julie Jacobson)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, knocks down Manny Pacquiao, from the Philippines, in the third round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, knocks down Manny Pacquiao, from the Philippines, in the third round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, knocks down Manny Pacquiao, from the Philippines, in the third round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, left, knocks down Manny Pacquiao, from the Philippines, in the third round of their WBO world welterweight fight Sunday, Dec. 9, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Manny Pacquiao

    Manny Pacquiao, from the Philippines, enters the ring before his WBO world welterweight fight Sunday, Dec. 9, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Juan Manuel Marquez, from Mexico, right, reaches against Manny Pacquiao, from the Philippines, in the first round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Manny Pacquiao, from the Philippines, left, and Juan Manuel Marquez, from Mexico, trade blows during their WBO world welterweight fight Sunday, Dec. 9, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao, Juan Manuel Marquez

    Manny Pacquiao, from the Philippines, left, lands a left against Juan Manuel Marquez, from Mexico, during the first round of their WBO world welterweight fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Eric Jamison)

  • Manny Pacquiao

    Manny Pacquiao, from the Philippines, enters the ring before his WBO world welterweight fight against Juan Manuel Marquez, from Mexico, Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Chelsea Emata

    Singer Chelsea Emata sings the Philippine national anthem before the fight between Manny Pacquiao, from the Philippines, and Juan Manuel Marquez, from Mexico, fight Sunday, Dec. 9, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Mitt Romney, Ann Romney

    Former Republican presidential candidate Mitt Romney, center, joined by wife Ann, right, talks with an unidentified spectator at ringside prior to a welterweight fight between Juan Manuel Marquez and Manny Pacquiao title fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Mitt Romney, Ann Romney

    **CORRECTS TO FORMER REPUBLICAN PRESIDENTIAL CANDIDATE**Former Republican presidential candidate Mitt Romney, left, and wife Ann sit near ringside prior to a welterweight fight between Juan Manuel Marquez and Manny Pacquiao title fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Mitt Romney, Ann Romney

    Republican presidential candidate Mitt Romney, left, and wife Ann sit near ringside prior to a welterweight fight between Juan Manuel Marquez and Manny Pacquiao title fight Saturday, Dec. 8, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Mike Tyson

    Former heavyweight champion Mike Tyson acknowledges the crowd before the weigh-in for a welterweight fight between Manny Pacquiao and Juan Manuel Marquez, Friday, Dec. 7, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • 50 Cent

    Rap artist 50 Cent acknowledges the crowd before a weigh-in for welterweight fight between Manny Pacquiao and Juan Manuel Marquez, Friday, Dec. 7, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Juan Manuel Marquez

    Juan Manuel Marquez reacts to the crowd after weighing in for a welterweight fight against Manny Pacquiao, Friday, Dec. 7, 2012, in Las Vegas. Marquez will face Pacquiao in their fourth fight on Saturday. (AP Photo/Julie Jacobson)

  • Manny Pacquiao

    Manny Pacquiao reacts after weighing in for Saturday's welterweight boxing match against Juan Manuel Marquez, Friday, Dec. 7, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

  • Manny Pacquiao, Juan Manuel Marquez

    Manny Pacquiao, left, and Juan Manuel Marquez pose for photos after the weigh-in for their welterweight fight, Friday, Dec. 7, 2012, in Las Vegas. The pair face off in the fourth fight against each other on Saturday. (AP Photo/Julie Jacobson)

  • Juan Manuel Marquez

    Juan Manuel Marquez weighs in for his welterweight boxing match against Manny Pacquiao, Friday, Dec. 7, 2012, in Las Vegas. Marquez and Pacquiao are scheduled to face off in their fourth fight on Saturday. (AP Photo/Julie Jacobson)

  • Manny Pacquiao, Juan Manuel Marquez

    Manny Pacquiao, left, and Juan Manuel Marquez pose for photos during the weigh-in for their welterweight fight, Friday, Dec. 7, 2012, in Las Vegas. Pacquiao and Marquez are scheduled to face off on Saturday in their fourth fight. (AP Photo/Julie Jacobson)