By Husmukh Kerai, Goal.com
The last-16 tie is delicately poised at 1-1 after a riveting first leg, while the Portuguese forward is back at his old stomping ground for the first time since leaving the club.
MANCHESTER UNITED
De Gea
Rafael, Evans, Ferdinand, Evra
Carrick, Cleverley
Welbeck, Rooney, Kagawa
Van Persie
REAL MADRID
Lopez
Arbeloa, Varane, Ramos, Coentrao
Khedira, Alonso
Di Maria, Ozil, Ronaldo
Benzema
Jose Mourinho has first-choice goalkeeper Iker Casillas back in his squad for the game at Old Trafford for the first time since Jan. 23, but it remains unlikely that the Spain international will feature.
Marcelo is also back in contention after recovering from injury and will push Fabio Coentrao for a place at left back.
The Real Madrid boss rested plenty of key players in the win over Barcelona at the weekend. Alvaro Arbeloa, Sami Khedira, Angel Di Maria, Mesut Ozil and Cristiano Ronaldo will all return to the starting line-up.
Phil Jones (ankle), who impressed in the first leg, is a doubt to feature on Tuesday, though Tom Cleverley is expected to come in for the Red Devils in midfield.
However, Rio Ferdinand is expected to return to the side after missing the win over Norwich at the weekend with illness.
Jonny Evans is likely to once again partner the Englishman in defence, with Nemanja Vidic who played at the weekend, missing out.
- The two previous Champions League encounters between Manchester United and Real Madrid at Old Trafford have produced 12 goals.
- Cristiano Ronaldo has scored seven goals in 23 Champions League games at Old Trafford. He has 16 goals in 18 European games at the Santiago Bernabeu.
- Angel Di Maria has four assists in the competition this season, all coming against Manchester teams - three against City and one against United.