The Kardashians thanked Handler by taking shots at her in her absence during the show. "I’m sure she’s busy doing something really important, like drinking," Kourtney said of the absent host.
"Or, having sex with somebody that she just met," Khloe said. Kim quickly added, "Or both."
The ladies also poked fun at themselves throughout the panel session with their mother, with Khloe calling out Kim for her ongoing divorce from Kris Humphries. Critical response appears to have been mixed, with Hollywood Life loving the sisters on late night, while Zap2It wondered if the audience was drunk. It was the only way they could think to explain them laughing at all.
See who shows up next on "Chelsea Lately," weeknights at 11 p.m. ET on E!
TV Replay scours the vast television landscape to find the most interesting, amusing, and, on a good day, amazing moments, and delivers them right to your browser.
Related on HuffPost:
HuffPost Entertainment is your one-stop shop for celebrity news, hilarious late-night bits, industry and awards coverage and more — sent right to your inbox six days a week. Learn more