The South Florida boy who has been battling a very rare infection at Miami Children's Hospital is brain dead and will be taken off life support Sunday night, according to his family.

Zachary Reyna, 12, was knee-boarding in ditch water in Glades County when he contracted Naegleria fowleri, brain-eating amoeba, through his nose.

Although antibiotics had successfully fought off the infection, Reyna suffered extensive brain damage.

The family indicated that Reyna has already "passed" after showing negative brain activity for days, but he will be kept on a ventilator until Sunday night so that his organs can be donated.

Saturday on Pray4Number4, the Facebook tribute for Reyna referencing the small number of primary amebic meningoencephalitis survivors, his father wrote:

Celebrities like Taylor Swift, reportedly Reyna's favorite singer, sent him gifts. The New York Yankees even sent him flowers and a balloon reading, "Get Well Soon."

The infection that claimed the young boy's life is very rare.

Center For Disease Control officials say there have been only 128 people infected with PAM since 1962. Only three have survived, including another Florida 12 year old who recently contacted the amoeba from a freshwater spring.

The CDC recommends diminishing risk by limiting water contact with nose (hold nose shut, use nose clips, or keep head above water), avoid water-related activities in warm freshwater during periods of high water temperatures and low water levels, and avoid stirring up bottom sediment in shallow, warm freshwater areas.

There have also been cases from use of Neti pots, in which contaminated water is used to irrigate the nose.

Clarification: A headline that appeared on another part of our website on Sunday morning indicated that Reyna was deceased, based on a family statement that he had "passed." As of Sunday afternoon, the Associated Press is reporting that the family says he has no brain activity but remains on a ventilator.

Also on HuffPost:

Loading Slideshow...
  • Gigantism

    This disease, which <a href="http://rarediseases.info.nih.gov/GARD/Condition/6506/Gigantism.aspx" target="_hplink">according to the NIH</a> is most often caused by a begnin tumor in the pituitary gland, results in an excess of GH, or growth hormone. This causes sufferers to grow abnormally large, not just in terms of height, weight but also organ size. It results in complications like delayed puberty, increased sweating, and secretion of breast milk.

  • Pica

    Characterized as an eating disorder, <a href="http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Pica" target="_hplink">Pica</a> causes people to eat what the <a href="http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Pica" target="_hplink">National Organization for Rare Disorders describes as</a> "non-nutritive" things. That umbrella term can include (but isn't limited to) dirt, clay, paper, and paint. Interestingly, it's not unusual for young kids to experience transient pica as a kind of phase, and <a href="http://www.americanpregnancy.org/pregnancyhealth/unusualcravingspica.html" target="_hplink">pregnant women</a> are also known to develop temporary pica cravings. The cause? Unknown. But in order to be diagnosed with full-blown Pica, a person's symptoms must last for more than a month.

  • Maple Syrup Urine Disease

    MSUD, which is passed down through families, is a life-threatening metabolic disorder passed down through families that stems from the body's inability to process certain amino acids, leading to a build-up of them in the body. <a href="http://rarediseases.info.nih.gov/GARD/Condition/3228/Maple_syrup_urine_disease.aspx" target="_hplink">According to the NIH,</a> symptoms usually surface in early infancy and can include vomiting, lack of energy, seizures, and developmental delays. MSUD takes its name from another symptom -- the urine in affected infants smells like caramel or maple syrup.

  • Situs Inversus

    Situs Inversus is a congential condition in which internal organs of stomach and chest lie in mirror image of their normal body position -- something many sufferers aren't aware of until they seek medical help for an unrelated problem. <a href="http://en.wikipedia.org/wiki/Situs_inversus" target="_hplink">People with Situs Inversus</a> typically wear some form of identification to help doctors in the case of a medical emergency.

  • Trigger Thumb

    Trigger thumb, or trigger finger as it's sometimes known, causes a person's finger or thumb to get caught in a locked position. <a href="http://www.mayoclinic.com/health/trigger-finger/DS00155" target="_hplink">According to the Mayo Clinic,</a> it can then stay stuck or straighten with a painful "snap." The cause? It depends. Trigger Thumb is the result of a narrowing of the sheath around the tendon in the problem figure, but that can be caused by a lot of things, including any activity that requires people to grip things frequently. Trigger Thumb is also more frequent in women.

  • Scurvy

    Once the disease of sailors and pirates, <a href="http://www.ncbi.nlm.nih.gov/pubmed/16911372 " target="_hplink">scurvy does still exist in the United States,</a> though predominantly in older, malnourished adults. It usually stems from a Vitamin C deficiency, which can result in gum disease, skin leisons, and swelling of the joints.

  • Wilson's Disease

    This progressive genetic disorder causes sufferers to store excess copper in tissues, including the brain and liver. <a href="http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Wilson's Disease" target="_hplink">Though the Mayo Clinic says</a> that the body depends on copper in order to use iron and sugar, too much of it in the body can have real consequences. Which is why sufferers of Wilson's Disease are prone to liver failure.

  • Foreign Accent Syndrome

    <a href="http://www.utdallas.edu/research/FAS/about/" target="_hplink">According to researchers at the University of Texas at Dallas,</a> this speech disorder causes people to experience a sudden shift in their accents and though it is known to be caused by things like brain trauma, conversion disorder, or multiple sclerosis, an exact reason behind the syndrome is unknown. Sufferers of FAS dramatically shift their speech in terms of timing and intonation, which often causes them to sound foreign, but they remain totally comprehensible. <a href="http://www.utdallas.edu/research/FAS/about/" target="_hplink">Documented accent shifts</a> include from American English to British and from British to French.

  • Stiff Person Syndrome

    People who suffer from this acquired neurological disorder experience repeated, often painful, muscle spasms as well as muscular rigidity and stiffness. <a href="http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Stiff Person Syndrome" target="_hplink">According to the National Organization of Rare Diseases,</a> spasms can occur at random or they can be caused by something as seemingly benign as light physical contact or an unexpected noise. The cause of Stiff Person Syndrome isn't yet known, but symptoms can be stabilized with medication. Left untreated, however, a person can lose the ability to walk.

  • Carcinoid Syndrome

    <a href="http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Carcinoid syndrome" target="_hplink">According to the National Organization of Rare Diseases,</a> about 10 percent of people with carcinoid tumors -- which <a href=" http://www.mayoclinic.com/health/carcinoid-tumors/DS00834" target="_hplink">the Mayo Clinic says</a> are slow growing tumors that produce excess serotonin and usually appear in the gastrointestinal tract or lungs -- get this syndrome. It occurs only in patients whose tumors have metastasized to the liver. The symptoms? Wheezing, hotness, and extreme facial blushing.

  • Cyclic Vomiting Syndrome

    Children and adults afflicted with <a href="http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Cyclic Vomiting Syndrome" target="_hplink">CVS</a> experience recurrent episodes of severe vomiting, which can last for days, followed by sudden periods of no vomiting. While kids are likely to experience more frequent attacks, adults's often last longer. To date, the cause of CVS is unknown.

  • Peeling Skin Syndrome

    This obscure, <a href="http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Peeling Skin Syndrome" target="_hplink">genetic skin disorder</a> does exactly what its name implies: causes sufferers to experience constant shedding of their skin. (In some patients, peeling is limited to the feet and hands.) Along with that, sufferers often feel itching and redness -- symptoms that can appear from birth or develop later in life. Although the exact cause is unknown, <a href=" http://www.nature.com/jid/journal/v130/n6/full/jid201023a.html" target="_hplink">a mutation in the TGM5 gene</a> has been identified in many sufferers.

  • Platelet Storage Pool Deficiency

    This is a blanket designation for several rare platelet abnormalities, most of which lead to mild or moderate bleeding disorders. <a href="http://rarediseases.info.nih.gov/GARD/Disease.aspx?diseaseID=5034" target="_hplink">According to the NIH,</a> the problem stems having limited granules -- the parts of platelets that, among other things, store ADP -- the energy released when a molecular bond is broken. That reduction in storage space inhibits the platelets' ability to secrete <a href="http://www.biology-online.org/1/2_ATP.htm" target="_hplink">ADP</a> in a speedy fashion, which is thought to be what causes the bleeding. Classic symptoms of a Platelet Storage Pool Deficiency are nosebleeds, excessive bruising, and profuse bleeding in surgery.·

  • ACDC

    Only nine people in the United States are known to have this disease, which was just given a name in a recent study in the<em> New England Journal of Medicine</em>. ACDC, or arterial calcification due to CD73 deficiency, results in calcium build-ups in the arteries below the waist of sufferers and in the joints of their hands and feet. <a href="http://rarediseases.info.nih.gov/files/NIH ArterialCalcNEJM-final.pdf" target="_hplink">According to the NIH,</a> the breakthrough discovery found that the disease is related to a variant in the NT5E gene.3

  • Conversion Disorder

    <a href="http://rarediseases.info.nih.gov/GARD/Condition/6191/Conversion_disorder.aspx" target="_hplink">This condition,</a> which typically occurs after an extremely stressful emotional event, causes a person to experience sudden blindness or paralysis that can't be otherwise explained. People with mental illlnesses are at particularly high risk and psychological treatment can help lessen the symptoms.·

  • Ochronosis

    Ochronosis results in black or blue external tissues, often the ear cartilage or eye, though it can occur throughout the body. It affects people who suffer from certain metabolic disorders, but it can also be caused by exposure, though <a href="http://www.ncbi.nlm.nih.gov/pubmed/11705248" target="_hplink">scientists</a> aren't exactly sure to what. Not just a cosmetic issue, the affected areas can become brittle and degenerate over time.

  • VLCAD Deficiency

    This condition, which is caused by genetic mutations in the so-called ACADVL gene, keeps people from converting certain fats to energy. <a href="http://rarediseases.info.nih.gov/GARD/Condition/5508/VLCAD_deficiency.aspx" target="_hplink">According to the NIH,</a> the deficiency often presents during infancy in symptoms including low blood sugar, weakness, and lethargy.

  • Hairy Tongue

    As the name suggests, Hairy Tongue is a condition in which the tongue develops a black, hairy texture. <a href="http://www.mayoclinic.com/health/black-hairy-tongue/DS01134 " target="_hplink">According to the Mayo Clinic,</a> the disease is "harmless" and is caused by an overgrowth of bacteria in the mouth, which can be treated with antibiotics. <a href="http://rarediseases.info.nih.gov/GARD/Condition/6561/Hairy_tongue.aspx" target="_hplink">The NIH reports</a> that hairy Tongue can also present as brown, yellow, or green discoloration. ·

  • Ochoa (Urofacial) Syndrome, or, Peculiar Facial Expression

    This obscure, inherited disorder presents at birth and causes infants to grimace when, in fact, they are attempting to smile. <a href="http://www.everydayhealth.com/health-center/ochoa-syndrome.aspx" target="_hplink">The disorder also includes</a> an extreme urinary abnormality: an obstruction that interrupts the connection between nerve signals in the spinal cord and bladder, leading to incontinence. <a href="http://rarediseases.info.nih.gov/GARD/Condition/104/Ochoa_syndrome.aspx" target="_hplink">Though treatment does exist</a> in the form of antibiotics and bladder re-education, some patients can develop renal failure in their teens and 20's, which can be life-threatening.

  • Eagle Syndrome

    This syndrome, caused by a particular calcified ligament or elongated bone, frequently causes sufferers to feel that something is stuck in their throat. (Scientists don't know the reason behind said elongation/calcification.) Other symptoms can include ear and throat pain as well as difficulty swallowing. <a href="http://rarediseases.info.nih.gov/GARD/Condition/9401/Eagle_syndrome.aspx" target="_hplink">According to the NIH,</a> it can be treated surgically or non-surgically with steroid injections and other anti-inflammatories.

  • Progeria

    <a href="http://www.mayoclinic.com/health/progeria/DS00936 " target="_hplink">According to the Mayo Clinic,</a> only around 130 cases of this devastating genetic disorder have been documented since it was discovered in 1886. Affected babies normally appear normal at birth, but within 12 months begin to have symptoms like hair loss and wrinkles. <a href="http://www.mayoclinic.com/health/progeria/DS00936 " target="_hplink">According to the Mayo Clinic,</a> progeria is caused by a genetic mutation, but not one that's passed down through families; it's a chance event that affects only one egg or sperm. The average life expectancy for sufferers is 13.