Mathews stopped by his old "Lately" stomping grounds Sept. 5, where he was interviewed by Chelsea Handler about his new hosting gig. The conversation inevitably turned to celebrities and pop culture, where Mathews shared his thoughts on Chaz Bono's new weight loss and how he would now "hit it."
Of course Handler couldn't let the joke go without making fun of Mathews. Click on the video above to hear her remarks as Mathews tries to defend himself.
"Hello Ross!" premieres tonight, September 6 at 10pm on E!