From "Seinfeld" to "The New Adventures of Old Christine" to "VEEP," Julia Louis-Dreyfus has established herself as the Picasso of playing smart but awkward single women on television. Now she's bringing her prowess to the big screen.

In "Enough Said," written and directed by Nicole Holofcener ("Friends With Money"), Louis-Dreyfus plays Eva, a divorced mom who falls for a divorced dad named Albert (James Gandolfini) -- only to find herself questioning the relationship when she gets an earful from the guy's ex-wife (Catherine Keener, in pretentious Earth Mother mode).

"Enough Said" premiered to applause and tears at the Toronto International Film Festival. The credits led off with a full-screen dedication that read, simply, "For Jim" -- a solemn nod to Gandolfini's untimely death in June at age 51. (This was the "Sopranos" star's last leading role.) The next day, HuffPost Entertainment sat down with Louis-Dreyfus to discuss her collaboration with Gandolfini, the future of Vice President Selina Meyer and the likelihood that she'll get coffee with her old sitcom buddy Jerry Seinfeld.

HuffPost Entertainment: When you were watching "The Sopranos," what would you say if someone said, “One day you are going to play in a romantic comedy with Tony”?

Julia Louis-Dreyfus: I would’ve said, “Bullshit.”

There’s a different side of him that comes out in this film, isn't there?

Yeah. The interesting thing is that James is really much more like Albert in this film than he ever was Tony Soprano. He’s not a Mafioso type. He is a very much a gentle giant of a man, as depicted in this movie.

Two of my female friends said to me after the film, "I can’t believe how sexy James Gandolfini was in that movie."

A lot of women feel that way!

What was it about him that made women react like that?

I think he has a thoughtfulness, a kindness, and a powerfulness that is irresistible.

I gather there was a lot of improvising. What was it like to improvise comedy with James Gandolfini?

He was nervous! But as the process began to unfold, he loosened up more and more. He was a little bit nervous maybe not only about the comedy part, but I think he was really questioning whether or not he was the right guy for this part. He’d make a lot of jokes at Nicole, saying, “If you want to call George Clooney, that’s fine.” But of course, he was perfect for the part. So the fact that he was questioning it made him that much more perfect for the part.

You’re the best at playing single women. I find it interesting that you’ve been married for over 26 years.

I know! Someone else just asked me that and it never even occurred to me. That’s how much of an idiot I am. It hadn’t even occurred to me that there is this same strain in these characters I’ve played all my life. It’s bizarre.

So it’s not like you go around asking your single friends for research advice? It all just comes to you.

Yeah, I guess.

This year, you surpassed Lucille Ball for most nominated person at the Emmys ever. How does that make you feel about your own career?

It feels good. It’s hard to believe that it’s true. I’m not sure people have counted correctly, but I’m not demanding a recount either. It seems surreal. I don’t feel like I’ve been doing it for that long, but I guess I have! Boy, it’s a lot of good fortune. It’s really bizarre.

Are you and the other best actress nominees planning anything exciting for us this year?

Maybe.

Are you going to do “Comedians In Cars Getting Coffee with Jerry Seinfeld”?

I think that show is so fabulous. I absolutely love it. Maybe. We’ll see. We haven’t had that conversation. If he asked me to do it, I’d love to do it.

What's the response to "Veep" among people you meet in Washington?

It’s huge! I think initially people weren’t necessarily sure of what we were doing. Were we satirizing a particular person or candidate? Now that it’s become clear that it’s really a fiction, more and more people have come to me and Armando Iannucci, who runs the show, to talk about the show and tell us what they like about it and tell us stories about their life in Washington, blah, blah, blah. It’s been wild, actually.

Have you been able to incorporate any of those stories into the plotlines?

You bet!

Now that Selina is running for president, does the show end if she wins?

I guess it would just mean a title change, right?

Have you met and talked with Vice President Biden about the show?

Yes, I have. He said he wished he could hit members of his staff that way that I hit the members of my staff. [Laughs.]

Does working on the show give you extra sympathy for people like President Obama?

Oh, my gosh. I have so much sympathy for anybody working in politics and government. Particularly nowadays. The balancing act of trying to stay alive politically while governing, while keeping your moral compass centered. I find that very daunting. I don’t know how they do it.

"Enough Said" opens Sept. 18.

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  • Julia Roberts

    Julia Roberts arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Harvey Weinstein

    Harvey Weinstein arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. The movie mogul talks to Associated Press in an exclusive interview about the "12-12-12" (Sandy benefit at MSG) documentary he premiered at TIFF, and how they amassed the biggest names in music. He also spoke about his TIFF premiere of "August: Osage County," and how proud he is of "The Butler." (Photo by Evan Agostini/Invision/AP)

  • Harvey Weinstein

    Harvey Weinstein arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. The movie mogul talks to Associated Press in an exclusive interview about the "12-12-12" (Sandy benefit at MSG) documentary he premiered at TIFF, and how they amassed the biggest names in music. He also spoke about his TIFF premiere of "August: Osage County," and how proud he is of "The Butler." (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts

    Julia Roberts arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Juliette Lewis

    Juliette Lewis arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Juliette Lewis

    Juliette Lewis arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts, Dermot Mulroney

    Julia Roberts, left, and Dermot Mulroney arrive at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts

    Julia Roberts arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Chris Cooper

    Chris Cooper arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts

    Julia Roberts arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts, Dermot Mulroney

    Julia Roberts, left, and Dermot Mulroney arrive at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts, Dermot Mulroney

    Julia Roberts, left, and Dermot Mulroney arrive at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Dermot Mulroney

    Dermot Mulroney arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Abigail Breslin

    Abigail Breslin arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Dermot Mulroney

    Dermot Mulroney signs autographs for fans at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Dermot Mulroney

    Dermot Mulroney arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Abigail Breslin

    Abigail Breslin arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Juliette Lewis

    Juliette Lewis arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts

    Julia Roberts arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julianne Nicholson

    Julianne Nicholson arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts

    Julia Roberts arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts

    Julia Roberts arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Ewan McGregor

    Ewan McGregor arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Ewan McGregor

    Ewan McGregor arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Dermot Mulroney

    Dermot Mulroney arrives at the premiere of "August: Osage County" on day 5 of the Toronto International Film Festival at the Roy Thomson Hall on Monday, Sept. 9, 2013, in Toronto. (Photo by Evan Agostini/Invision/AP)

  • Julia Roberts

    Actress Julia Roberts poses for a photograph on the red carpet at the gala for the film "August, Osage County " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Chris Cooper

    Actor Chris Cooper poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Chris Cooper

    Actor Chris Cooper poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Juliette Lewis

    Actress Juliette Lewis poses for a photograph on the red carpet at the gala for the new movie " August, Osage County " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • John Wells

    Director John Wells poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Juliette Lewis

    Actress Juliette Lewis poses for a photograph on the red carpet at the gala for the new movie " August, Osage County " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Abigail Breslin

    Actress Abigail Breslin poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Abigail Breslin

    Actress Abigail Breslin poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Abigail Breslin

    Actress Abigail Breslin poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Abigail Breslin

    Actress Abigail Breslin poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Abigail Breslin

    Actress Abigail Breslin poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Dermot Mulroney

    Actor Dermot Mulroney poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Dermot Mulroney

    Actor Dermot Mulroney waves as he signs autographs for fans on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Abigail Breslin

    Actress Abigail Breslin poses for a photograph on the red carpet at the gala for the film "August, Osage County" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Julia Roberts

    Actress Julia Roberts poses for a photograph on the red carpet at the gala for the film "August, Osage County " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Julia Roberts

    Actress Julia Roberts poses for a photograph on the red carpet at the gala for the film "August, Osage County " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Julia Roberts

    Actress Julia Roberts poses for a photograph on the red carpet at the gala for the film "August, Osage County " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Scarlett Johansson

    Actress Scarlett Johansson wears a ring as she poses for a photograph on the red carpet at the gala for the new movie " Under The Skin " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Scarlett Johansson

    Actress Scarlett Johansson poses for a photograph on the red carpet at the gala for the new movie "Under The Skin" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Jonathan Glazer, Scarlett Johansson

    Actress Scarlett Johansson poses for a photograph on the red carpet at the gala for the new movie "Under The Skin" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Scarlett Johansson

    Actress Scarlett Johansson poses for a photograph on the red carpet at the gala for the new movie " Under The Skin " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Scarlett Johansson

    Actress Scarlett Johansson poses for a photograph on the red carpet at the gala for the new movie " Under The Skin " during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Jonathan Glazer, Scarlett Johansson

    Actress Scarlett Johansson, right, and director Jonathan Glazer pose for a photograph on the red carpet at the gala for the new movie "Under The Skin" during the 2013 Toronto International Film Festival in Toronto on Monday, Sept. 9, 2013. (AP Photo/The Canadian Press, Nathan Denette)

  • Paul Haggis; Liam Neeson; Mila Kunis; Adrien Brody; Olivia Wilde; Moran Atias; Maria Bello, Loan Chabanol

    Actors Adrien Brody, left, and Liam Neeson, centre, pose for a photograph with director Paul Haggis, right, on the red carpet at the gala for the new movie "Third Person" during the 2013 Toronto International Film Festival in Toronto on Monday, September 9, 2013. (AP Photo/The Canadain Press, Michelle Siu)

  • Paul Haggis; Liam Neeson

    Writer and director Paul Haggis, right, and actor Liam Neeson, left, pose for a photograph on the red carpet at the gala for the new movie "Third Person" during the 2013 Toronto International Film Festival in Toronto on Monday, September 9, 2013. (AP Photo/The Canadian Press, Michelle Siu)

  • Liam Neeson Adrien Brody

    Actors Adrien Brody, left, and Liam Neeson, right, pose for a photograph on the red carpet at the gala for the new movie "Third Person" during the 2013 Toronto International Film Festival in Toronto on Monday, September 9, 2013. (AP Photo/The Canadian Press, Michelle Siu)