CLEVELAND -- CLEVELAND (AP) — Buffalo rookie quarterback EJ Manuel left the Bills' game Thursday night against the Browns with a knee injury, and the team said his return was doubtful.

Manuel was hit on the right knee by Browns safety Tashaun Gipson at the end of a 14-yard run. Manuel stayed down in obvious pain and then walked slowly to the sideline before he was replaced by rookie backup Jeff Tuel. Manuel tried to get his loose on the sideline, jogging and riding a stationary bike. Trainers examined his knee before taking him to the locker room.

Manuel was 11 of 20 for 129 yards.

Earlier, Browns quarterback Brian Hoyer went down with a right knee injury and coach Rob Chudzinski told NFL Network he was fearful of torn ligaments.

GIF: here's the back-leg hit that E.J. Manuel went down ... on Twitpic
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