And now, in an interview with HuffPost Live on Thursday, Nye explained his new view of GMOs, saying they had brought some big benefits to agriculture.
"GMOs are not inherently bad," he told host Josh Zepps. "We are able to feed 7.2 billion people, which a century and a half ago you could barely feed 1 and a half billion people and [it's] largely because of the success of modern farming."
But Nye urged caution, particularly because introducing new organisms into the ecosystem can have "unintended consequences."
"My take on it now is genetically modified food is actually, in general, -- genetically modified plants, in general, -- are not only not harmful, they're actually a great benefit. However, you can't just go planting enormous monocultures and killing everything and expect the ecosystems to take it," he said.
Watch the full HuffPost Live interview with Bill Nye here.
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