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Athena Andreadis, Ph.D.

Athena Andreadis, Ph.D.

Posted: May 7, 2010 03:09 PM

Neanderthal Genes: The Hidden Thread in Our Tapestry

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There have been many branches on the hominid tree, but now a lone species walks the earth. We had company once, though, at least in Europe and West Asia - the Neanderthals.

Until recently, the scientific consensus was that they were sufficiently different from Homo sapiens that no interbreeding took place. We knew that they controlled fire; constructed tools, shelters and garments; took care of their weak, injured and elderly; and buried their dead with grave goods. But until two decades ago it was widely believed that they had attributes which disadvantaged them to such an extent that competition with modern humans led to their extinction (for example, lack of capacity for complex language, almost exclusive dependence on hunting for sustenance... to say nothing of the Tarzanist view that their doom came about because -- horrors! -- they allowed women to join the hunt).

This idea of Neanderthals as grunting, shuffling dead-end cavemen began to change as our techniques allowed us to examine Neanderthal fossils with more precision and depth. In the mid-eighties, bone and genetic analysis proved that their ability to hear and produce sounds was almost identical to ours (including a human-like FOXP2 gene, whose function is critical for language). Sequencing of their melanocortin gene indicated that some might have red hair and light skin.

Finally, the just-published draft sequence of their genome (headed by Svante Pääbo's team from the Max Planck Institute) showed that up to 4% of the genes of non-Africans may come from them. If confirmed, this means that Neanderthals and Cro-Magnons indeed interbred when the latter first came out of Africa - most likely in the Middle East, before further migration outward.

The two branches of humanity share 99.7% genetic identity. They show differences in genes involved in cognitive development, skeleton structure, energy metabolism, skin physiology. They also differ in regulatory regions and microRNAs. This information will eventually help us answer the question of what makes us uniquely "human" - perhaps even what has made us so adaptable that we now threaten to overwhelm the earth.

When I read about the conclusions from the draft sequence analysis, tears sprang to my eyes, just as they do at spaceship and planetary probe launches. It moved me inexpressibly to think that they haven't vanished but are with us still, a thread in our fabric, a whisper in our song.

Note 1: The best fictional depiction of the interaction between Neanderthals and Cro-Magnons is Dance of the Tiger by Björn Kurtén, a distinguished vertebrate paleontologist who was Swedish -- as is Pääbo.

Note 2: This article is also on the author's blog, with a nifty graph that shows the genetic interweaving.

 
 
 
 
 
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12:10 AM on 05/12/2010
I read somewhere that it was three neanderthal bones and specimens from 5 living humans that was tested. I do think that a sample of 5 human beings is an inadequate sample to cover the genotypes available in Africa let alone the whole world. What is to say that the supposed neanderthal genes allegedly that current humans possess weren't from a distant common ancestor to the two types of hominid present tens of thousands of years ago?
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
12:18 AM on 05/12/2010
As I said to an earlier commenter: This possibility is less likely but has not been formally excluded, particularly because the two African samples they included in their work came from ethnic groups from the south (San) and the west (Yoruba) of the continent. I think they plan to analyze samples from areas closer to northeast, to investigate the likelihood you described.

If you go to their paper (available online, http://www.sciencemag.org/cgi/content/full/328/5979/710) and look at Figure 6, you will see all the possible scenarios for their results.
08:34 PM on 05/09/2010
Ever seen movie "Quest For Fire" ? Heck, male humans will have sex with a bundle of straw.
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
08:48 PM on 05/09/2010
I loved that movie! Although I guessed right away that 1) a woman would teach them how to make fire and 2) she would furthermore show one of them how to make love face-to-face (a scenario also used in Elizabeth Marshall Thomas' wonderful Animal Wife). I found it touching that it begins and ends with a small bonfire burning in the darkness. Perhaps a fitting symbol for the human spirit at its best.
10:19 PM on 05/09/2010
I find it improbable our ancestors knew how to keep a torch smoker going and not know how to use flint and friction. Historical evidence seems to indicate neanderthal and homo sapien used friction.
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Kache
Citizens, Unite!
06:32 PM on 05/08/2010
Since Neanderthal DNA has been found in Humans, but Human DNA was not found in Neanderthals, this suggests selective breeding - both Human and Neanderthal males were breeding with Human females, but Human males were not breeding with Neanderthal females, or at least not nearly as frequently as Neanderthal males were breeding with Human females.

There is of course the possibility that Human females were simply more attractive or produced a lower infant mortality rate. But, among current primates only the Human and Bonobos species females have a menstrual cycle while others have a estrus cycles. The difference is sexual receptivity. A primate with a estrus cycle would be receptive only during ovulation, which may be only a few days monthly or even only a few days a year depending on the species. A primate with a menstrual cycle is typically receptive at all times.

Since Neanderthals appear to have developed in a climate of sever climatic variation, it is likely that a seasonal estrus cycle would have been beneficial for the survival of offspring. Conversely, Humans evolved in a climate where that would not have been a benefit.

Rather than out thinking, out hunting, or our farming Neanderthals, is it possible that the ever-present "girl next door" was tearing the Neanderthal's family and tribal cohesion apart?
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
06:44 PM on 05/08/2010
The study is based on 2/3 of the Neanderthal genome, and has not yet excluded gene flow in the other direction. Also, we have infinite numbers of human samples but few and fragile Neanderthal fossils, so getting a complete picture of the latter won't be easy.

Farming came into existence a lot later, so it doesn't enter the equation at all. One possibility is that the Neanderthals' apparently heavier reliance on game made them less adaptable than the Cro-Magnons, who depended a lot on gathering -- done mostly by women. So I think the women played a constructive role, not a destructive one.

The menstrual theory doesn't hold up to close scrutiny. For one, if bonobos have menstrual cycles, all hominids -- not just Cro-Magnons -- also would, since they came from a common ancestor shared with the bonobos. For another, if we judge by what we know about today's few left gatherer-hunters, women of those groups are lean enough that they're fertile only very intermittently, regardless of their sexual receptivity.
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Kache
Citizens, Unite!
07:44 PM on 05/08/2010
I was unaware that bonobos are considered common ancestors to all hominids. Thanks for that info.

I've read elsewhere that, based in physiology, Neanderthal would have been the more likely gatherer, the hip structure and muscularity being more suited to the rapid short movements of gathering, while the human running gait would be more adaptable to following game and even outrunning large game over long distance. Apparently you disagree. I'm curious why.

BTW, thank you ever so much for engaging with your readers like this!!!!
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LMPE
I connect the most dissimilar things
05:08 PM on 05/08/2010
And let me guess:

the Neanderthals rode dinosaurs 6,000 years ago!
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
05:14 PM on 05/08/2010
Nope, only woolly mammoths!
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12:18 PM on 05/08/2010
There's a guestion I've always wanted to ask that I've never heard addressed. If the human race can manage to not destroy the planet and life as we know it continues to evolve, will our current ape species ever evolve into humans? Sorry if that's a dumb question. Also, what changes would you predict in humans?
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
12:39 PM on 05/08/2010
A very interesting question!

The possibility that either we or primate relatives would branch into additional species is not formally excluded. However, for such a thing to happen, we need isolated groups (so-called founders) that will be isolated long enough to start diverging to the point of eventually becoming a new species -- defined by the inability to interbreed with the rest.

The problem is that humanity now occupies the entire planet. This means that 1) there are no isolated human populations and 2) we have disturbed the habitat of related primates to the point that they are about to become extinct. This configuration leaves little room for branching into new species.

However, there is a scenario that will create speciation, and do so much faster than the usual time frame: if we embark on long-term space travel or planetary colonization, the resulting isolation and the pressures from planetary parameters that differ greatly from terrestrial ones will result in distinct human species. Each spaceship will effectively be a founder population.

It is also possible that settlers on other planets will have to resort to genetic engineering to meet the challenges of their new home. This, too, may result in speciation if they engineer the germline. I discuss this more extensively in Making Aliens, a six-part artlcle starting at http://www.starshipreckless.com/blog/?p=24.
KirkDiggler
My micr0-bio is half empty.
07:01 PM on 05/10/2010
Regarding the space travel theory creating new populations of human off-shoots: Since humans have evolved larger brains than their animal counterparts, isn't it less likely we would evolve into a new species of humanity, since if we had the technology to travel in space or distant worlds, we would be much more likely to adapt our environment to us, rather than be forced to adapt to new environments through some useful mutation? Even isolated human populations would still be able to breed with humans on other planets assuming there was nothing causing genetic changes in either colony. No?
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11:00 AM on 05/08/2010
I don't understand the research methodology, but has the source of the shared DNA been excluded from a common ancestor of both neanderthals and homo-sapiens?
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
12:19 PM on 05/08/2010
This possibility is less likely but has not been formally excluded, particularly because the two African samples they included in their work came from ethnic groups from the south (San) and the west (Yoruba) of the continent. I think they plan to analyze samples from areas closer to northeast, to investigate the likelihood you described.

If you go to their paper (freely available online, http://www.sciencemag.org/cgi/content/full/328/5979/710) and look at Figure 6, you will see all the possible scenarios for their results.
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01:02 PM on 05/08/2010
Yes indeed, and it wouldn't be surprising if a large part of the other 95% identical genes trace back even further. It's also interesting to us that "...gene flow may have taken place without leaving traces in the present-day gene pool".
09:40 AM on 05/08/2010
Just a few years ago some researchers "proved" that Neanderthals definitively did not breed with humans. (These geniuses are now working in cold fusion reactors and perpetual motion technology).

Two years later...voila! We see neanderthal genes identified not just in Geico adds but by illustrious statesmen like Henry Kissinger (seriously...make the comparison!)

The list of prior assertions now proven false are troubling. So Neanderthals could speak, make stone tools better than us (we?) at times, had 10% larger brains, used complex mixtures to form make-up, buried their dead with flowers, and mated with humans and produced fertile offspring? We’re clearly getting short changed by academia on this topic.

And we're still saying they were a different species? I'm confused. The mating of social politics and science usually makes my head spin that way.
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
12:23 PM on 05/08/2010
See my answer to GearRatio below about interbreeding.

Also, conclusions in science change as more data come in and as techniques to observe and interpret them improve. That's why it's called science, not religion.
06:12 AM on 05/08/2010
Modern humans and Neanderthal humans lived in shared territories in Europe and the Middle East for several thousands of years; over that long a period of time, it seems certain that their must have been some sexual contact between the two populations. After all, humans have been known to have sex with livestock...

Since earlier studies of mitochondrial DNA had seem to show that our modern populations are not genetically related to Neanderthals, had figured that the two species must not have been inter-fertile, or that they produced only sterile hybrids, as horses and asses do. It was nice to see this new study of the full Neanderthal genome (first draft) showing that there must have been viable interbreeds after all!
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
11:50 AM on 05/08/2010
We inherit mitochondria exclusively from our mothers. So the two sets of data are completely reconcilable if we assume that Cro-Magnon women mated with Neanderthal men and/or that by some chance only the children of these particular unions survived (or were fertile enough) to have descendants.
06:58 PM on 05/08/2010
Ah, quite so! And, in the case of horses and donkeys, worth noting that there have been a very few cases of fertile mules (sired by male asses of horse dams) but no cases of fertile hinneys (sired by male horses of ass dams). So, not beyond reason that a similar disparity in viability (or fertility) may have obtained in the case of Neanderthal / Cro-Magnon hybrids!
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Valkyrie Ice
Writer for H+ Magazine, and commenter at random
01:37 AM on 05/08/2010
Hi Athena.

I must admit the the first thought that crossed my mind upon reading this was to laugh my a$$ off at the thought of all those white supremacists who have been calling African Americans sub-humans discovering that the opposite is true. *giggle*

Who says Karma has no sense of irony?
12:11 AM on 05/08/2010
I wonder what happened when the first homo sapien family on the block had a daughter bring home a neanderthal. This story no doubt will inspire a musical based on Romeo and Juliet that will examine this epic confrontation. Mickey Rourke can play Romeo Neanderthal. It's the role he's been devolving into, anyway.
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
12:27 AM on 05/08/2010
I have no doubt the Sturm und Drang (aka conniptions) were worthy of Shakespeare -- nay, Wagner!

Yet think of the Elf-Human couplings in Tolkien. Granted, there are only three of them, and the human partners supposedly were la crème de la crème of their species. But unlike Neanderthals and Cro-Magnons, who were very similar, Elves are presented as far superior to Humans. Yet nobody cringes at the idea of Arwen mating with Aragorn.
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King Cashaw
06:40 AM on 05/08/2010
I wonder if it is because the Elves were all white, and shown to be very beautiful? To use another example, Capt. James T. Kirk was on anything he could mate with, but the only episode which caused Star Trek any issue was the one of Uhura and Capt kissing.
09:56 AM on 05/08/2010
Maybe Neanderthals were forced to breed...like in LOTR with the half-goblin men. Or they bred out of necessity, like with Sam and Frodo "in the wild". Those little bastards 'el breed with anything.
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robotfog
Victim of Technology
09:40 PM on 05/07/2010
Generally I wish I were anything but human, but I'm not sure how I feel about this possibility. Not that I look down upon Neanderthals but I'm stuck with this horrifying image of how the 'romancing' might have looked. I wonder how the in-laws interacted?
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
10:33 PM on 05/07/2010
Well, humans weren't happy when they first realized they were descended from apes, either. As a Victorian lady exclaimed, “Oh dear, let us hope Mr. Darwin isn’t right – and, if he is, let us hope no one finds out about it!”

Why is the image horrifying? They looked almost identical -- as different (or as similar) as members of different races. A great book about how an equivalent romancing might have happened and looked is Elizabeth Marshall Thomas' The Animal Wife.
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robotfog
Victim of Technology
03:56 PM on 05/08/2010
I guess you're right. I just have this preconceived notion of Neanderthals being incredibly huge. I was thinking people would get hurt.
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05:13 PM on 05/07/2010
That's "Mr. Neanderthal, to you."
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Athena Andreadis, Ph.D.
Scientist by day, writer by night.
05:43 PM on 05/07/2010
Yes, of course!