Katherine Heigl became a box-office sensation starring first in Judd Apatow’s smash hit comedy, Knocked Up, followed by a starring turn with Ed Burns and James Marsden in the romantic comedy, 27 Dresses, and then opposite Gerard Butler in the romantic comedy The Ugly Truth, which she also executive produced. These earned Heigl “Female Star of the Year” honors at the 2010 ShoWest awards.

Heigl next stars with Robert DeNiro, Diane Keaton, Susan Sarandon and Robin Williams in the comedy feature The Wedding.

Heigl’s film credits include One for the Money, based on the first novel in the best-selling series by author Janet Evanovich; Gary Marshall’s ensemble comedy, New Year’s Eve; Life As We Know It, opposite Josh Duhamel, directed by Greg Berlanti; the action comedy Killers, opposite Ashton Kutcher for director Robert Luketic; the comedy The Ringer, Steven Soderbergh’s critically acclaimed depression-era drama King of the Hill, Under Seige 2: Dark Territory, Stand-Ins and That Night. Her first feature film leading role was in Touchstone Pictures’ My Father the Hero, starring opposite Gerard Depardieu.

On television, for six seasons, Heigl portrayed Dr. Isobel “Izzie” Stevens, the small-town girl constantly battling for respect amongst her peers, on ABC’s critically acclaimed drama Grey’s Anatomy. In 2007, Heigl earned an Emmy Award and a Golden Globe nomination for her performance. Heigl also starred on the WB sci-fi drama series, Roswell.

This past year, Heigl directed a music video for her husband Josh Kelley, of the song he wrote for his acclaimed 2011 album, Georgia Clay, about their daughter, Naleigh Moon, The video, a family affair, features home footage of the couple with their three-year-old daughter, Naleigh.

In May of 2009, Katherine Heigl and her mother Nancy launched the Jason Debus Heigl Foundation in honor of her older brother, who died much too young in an automobile accident and whose strong, compassionate nature and great love of animals was the cornerstone of their endeavors. The Heigls are using their resources to work directly to address the pet population crises in Los Angeles and across the country.

Toward that goal, the Foundation launched the “Compassion Revolution” in September of 2010, pledging over one million dollars to a variety of low cost and free spay/neuter programs in Los Angeles and surrounding counties, as a key component to reducing the number of animals in shelters. The Foundation also presently funds pet education programs, actively supports spay/neuter programs, pet adoption programs, and funds and supports small dog transport from local kill shelters to both no kill shelters and rescues facilities throughout the country. To date the Foundation has funded more than 5500 spay/neuter surgeries, the transport of over 1400 animals out of high kill shelters to areas where they are rapidly adopted and an overwhelming variety of adoption and training programs intently focused on improving the plight of our pets.

This November, Katherine Heigl launched Just One, a line of specially designed pet products, for which a portion of each sale will support animal welfare efforts and programs.

Katherine Heigl also actively supports Donate Life, the organ donation foundation.