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Candy Gunther Brown, Ph.D.

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What Counts as Legitimate Scientific Research on Prayer?

Posted: 04/11/2012 7:01 am

I am pleased to see the lively exchange of comments generated by my recent post: "Testing Prayer: Can Science Prove the Healing Power of Prayer?" Many people have raised difficult and important questions that I have been thinking about for years. These questions can roughly be grouped into six categories: scientific methods, evidence, alternative explanations, other studies showing null results, theology and presuppositions.

My book, Testing Prayer: Science and Healing, is the outcome of my efforts -- in collaboration with a team of biomedical and clinical researchers -- to work through these questions over the past eight years. The book traces a history of why empirical research on prayer tends to be controversial (as responses to my blog post illustrate), as well as arguing that -- despite inherent difficulties -- there is reason to pursue such research, and suggesting how researchers might go about it. I would invite those who raised objections to my previous post to read the book as a basis for more in-depth discussion of the issues, since the book directly responds to many of the comments. In this post, I want to give some very brief responses based on a fuller treatment in the book.

My basic response is this: Prayer effects should be subject to the same standards as other research. This means that standards should not be lower, nor should they be higher. Anyone who argues for lower standards risks confirmation bias, and anyone who argues for higher standards (than for other empirical research) ends up advocating for double standards, thus betraying their metaphysical presuppositions. It is important to distinguish observable effects from a separate question of what causes those effects. In a properly done study, an effect is an effect, and a null result is a null result, regardless of prior beliefs and desired outcomes.

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Could a placebo effect be responsible for at least some of the outcomes observed after prayer? Absolutely. But a more interesting question is how far do placebo effects extend, and relatedly, where do prayer effects fall relative to known placebos? To say it is all placebo and then dismiss further inquiry is about as useful as saying physics is all quantum mechanics anyway, and we know it exists so why bother studying it? Some would argue that if prayer doesn't work for everyone all the time, then it must not yield valid effects. But many medicines are not 100 percent effective, and effectiveness may even vary across genetic groups, but that doesn't mean the medicines are useless. The point is that if any effect can lead to significant improvements in certain health problems, such as hearing and vision impairments, in at least some population, then that should be interesting as a potential therapy regardless of cause. It is easy enough to suppose that prayer practitioners are wrong in their assumption that a deity is responsible for healing, and natural explanations may be found. Nevertheless, merely asserting the existence of natural mechanisms and then poking one's head in the sand without engaging the data doesn't tell us anything new.

Since some criticisms of my earlier post focus primarily on clinical and statistical methods -- although this is only one of the four "cameras" used by the book to examine prayer -- I'll say more about these methods. A "Study of the Therapeutic Effects of Proximal Intercessory Prayer (STEPP) on Auditory and Visual Impairments in Rural Mozambique" was published in the peer-reviewed Southern Medical Journal; results and responses to critics are discussed at length in the book.

The Mozambique (and Brazil) studies used a widely accepted within-subjects design as the most efficient way for a preliminary study to test whether any effects exist -- before attempting to isolate mechanisms, placebo or otherwise. The study did control for potential confounds in other relevant factors. Within-subject designs (as opposed to between-subjects designs) do not use a separate control group. There is a long tradition of using within-subjects designs for psychophysical studies including vision and hearing, even with relatively small numbers of subjects. The results of these studies have been (and continue to be) published in well-respected journals, for example the flagship Science magazine. If the STEPP results are invalid for using a within-subjects design, then so are thousands of other published studies that use similar methods, unless one applies an indefensible double standard. Now that preliminary research has suggested the existence of an effect, it would be appropriate to use a between-subjects design, one that does utilize a separate control group and certain types of blinding, in developing more refined protocols.

Even with the smaller sample size of the STEPP study, there were large enough effects in individual subjects and consistent effects across the study populations for the results to reach statistical significance for both hearing and vision improvement following prayer. A smaller sample size does not mean that the results are un-generalizable. Smaller sample sizes simply require a larger effect size in order to reach statistical significance. Can the significant improvements in visual acuity and hearing thresholds really be attributed to a mechanism acting via prayer? Correlation does not equal causation, but the real question is whether the degree of improvement after PIP (without medical treatment) is greater than the degree of recovery that occurs spontaneously or through other means. Past studies actually show that hypnosis and suggestion can yield tiny improvements in visual acuity, but the improvements we measured were orders of magnitude larger, to the point that many individual cases could be considered "black swan" events. We have also ruled out ambient noise, practice effects, Hawthorne effects, demand effects, and holdback effects as potential confounds. Nor are the results anomalous--they were replicated months later in a separate country. What remains is a set of strong effects that invite further investigation and explanation.

 
 
 

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I am pleased to see the lively exchange of comments generated by my recent post: "Testing Prayer: Can Science Prove the Healing Power of Prayer?" Many people have raised difficult and important questi...
I am pleased to see the lively exchange of comments generated by my recent post: "Testing Prayer: Can Science Prove the Healing Power of Prayer?" Many people have raised difficult and important questi...
 
 
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Jradxit
Faithless morality over baseless faith
10:23 AM on 04/18/2012
One must apply more rigorous standards of proof for extraordinary claims than for ordinary claims. This was true for quantum mechanics and for effectiveness of prayer. One has withstood scientific scrutiny and one has not.
05:47 PM on 04/17/2012
Here's a simple experiment. Find 1,000,000 people who believe that prayer heals and have them pray ten times a day for various amputees who have volunteered their names. Do this for five years and then get back to me with how many have regenerated limbs. Case closed.
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onionboy
Blessed are the Cheese Makers
02:23 PM on 04/17/2012
Trying to demonstrate any faith using science merely demonstrates a lack of faith.

Which is fine. I'm simply pointing out that if you need evidence, it's not faith.
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ZenSufi
Sisters and Brothers of America!
10:14 PM on 04/17/2012
Even Jesus gave Thomas empirical evidence.
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onionboy
Blessed are the Cheese Makers
11:52 PM on 04/17/2012
Sure. Because he had no faith. Once he had some evidence then he just believed.
02:07 PM on 04/17/2012
Someone has seen Ghostbusters one time too many. LoL
12:44 PM on 04/17/2012
This is a clear account of some of the key issues. There is however an underlying problem that is rarely discussed. Where the effectiveness of prayer in improving healing outcomes is sometimes shown to be statistically significant, the correlation is usually shown to be slight. Since most of the conditions tested are also suseptible to improvement as a result of medical intervention and since the correlations are usually much higher maybe if healing is the intention a prayer supplicant would be better to put the effort into supporting conventional medicine unless it is a condition for which there is no known effective medical treatment. eg it was fine to pray and chalk a cross on the door to avert the plague when there was no alternative particularly if it at least made those involved feel that something was being done. However when the connection with rats and fleas as carriers was eventually established this became the focus of rational disease prevention.
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Don Cameron
12:36 PM on 04/17/2012
How about trying a real scientific study done on heart patients.

http://www.ncbi.nlm.nih.gov/pubmed/16569567

The results were that if anything, knowing that someone was praying for them had an adverse affect. Other than that, prayer did absolutely nothing. I'm wondering why you didn't mention this study... Probably because it didn't come to the conclusion you wanted. I cray BS...
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treemeizer
Stardust, temporarily human.
12:30 PM on 04/17/2012
So this blog post was essentially a pitch for a book, with no real meat to it; dissapointing.
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umbriago
The Tooth Shall Set My Fee
11:52 AM on 04/17/2012
When I was a Catholic kid, we had to go to Mass everyday. At certain times we were supposed to bow our heads in fervent prayer for a few moments. Try as I might, my mind would drift from thoughts of the Blessed Mother to wondering what the girl in the pew across from me looked like naked.

As far as I was concerned, I was "praying." Could I have been used as a subject in one of these studies?

Which brings me to the question: What, exactly, is prayer?
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The Kamala Farang
Bad to the Bone
12:58 PM on 04/16/2012
Dr.
You're saying that you used scientific research to find prayer worked? Really?

Forget the scientific research reaching a verifiable conclusion. Let's look at the logic.
Premise: Prayer works.
Premise: God fulfills prayers.
Conclusion: There is a God.

Well, that makes it a done deal, then.

Your scientific research is going to be...questionable. Every time I see science and God in the same post I put on waders.
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03:05 PM on 04/17/2012
I find your second premise to be questionable. You are assuming (based on your particular 'faith' or 'belief' that it is a 'Deity' that fulfills prayers. If Premise A is found to be true, a highly questionable conclusion, it does not automatically follow that Premise B is true.
06:56 PM on 04/15/2012
Your Eternal Self by Craig Hogan contains over 300 cites, many to hard science (peer reviewed studies and such, from major universities, labs, and leading researchers) showing the FACT that psi phenomena (like the positive effects of prayer) have been established, if not explained. My guess is that not a single skeptic on this Huffpost thread is even remotely aware of this evidence, coming from science itself, which undermines the 19th/20th century paradigm of a purely physical, random, mechanistic universe. The ignorance of many religious folk about science is mirrored by that of many scientific folk about things spiritual, even when scientically validated. The history of science is filled with paradigm-shifting discoveries that were dismissed out of hand and mocked by the scientific establishment. Check out what was said by science writers about the "lying" Wright brothers who claimed to have flown.
ThinkCreeps
Seriously, it's time.
09:32 AM on 04/17/2012
Note that R. Craig Hogan, the author of random self-published website `Your Eternal Self',
is not Craig Hogan, professor at the University of Chicago and director of Fermilab.
01:19 PM on 04/17/2012
It's not Craig Hogan. It's the more than 300 cites in his book. A good number of them reference some pretty hard science. Psi phenomena have been well-documented. The U.S. government has spent millions on things like remote viewing (and may still be doing so), with occasionally stunning results. Now what all of this psi stuff MEANS...that's another question and should be an interesting debate between believers and skeptics, so long as the discourse remains civil.
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onionboy
Blessed are the Cheese Makers
02:22 PM on 04/17/2012
I assume you mean citations. Please provide one. Here, I'll start.

http://www.ncbi.nlm.nih.gov/pubmed/16569567
03:31 PM on 04/17/2012
All citations to the scientific research in the book Your Eternal Self are available on the web site by the same name. I'll check out the cite you sent me, and thanks.
02:13 PM on 04/15/2012
Religion is not the same as God, Christ, and the Bible, for example, and I wish we would stop confusing them. That is where all the trouble begins in life. If all we did was a true in depth inductive, deductive, on multiple levels study of the Bible, cross referencing old and new testament and living as Christ, then you wouldn't have had the historical negatives of Christianity.
02:10 PM on 04/15/2012
In prayer you open your heart, mind and your spirit to healing, to any vibration in the universal sphere that can facilitate God for those of who are religious sending that assisting vibration, angel or such to you for healing. Also, the Bible is clear that the mind is potent and a potent weapon against many things. The mind, combined with the atoms etc.. in our bodies, in the universe, and God are a potent force.
01:45 PM on 04/15/2012
Scientific study requires an initial hypothesis that is falsifiable. For example - "cancer patients who are prayed for by at least ten people weekly for over a year live on average ten years longer than those who are not prayed for". Feel free to change the ten into anything even a negative number - but set it before you begin. Standard statistics will tell you how many tests you need to get conclusions like "It is 95% likely that the hypothesis is false (or true)".

Note - you will never disprove or prove anything - only get confidence levels.

I can see no hope for this kind of research and would, myself, waste neither time nor money on it. But you never know for sure.
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crydespite
no-one is ever 'just saying'
08:37 AM on 04/15/2012
Have a group pray for the reversal of cancer in a group of sufferers. Double blind, would not know who they were praying for and the people being prayed for would not know the experiment was going on. And another would not be prayed for as a control. A final group would be told that someone was praying for them to check for placebo effects.

Then repeat the experiment for a group of amputees. Sorry to be brutal and I know this is an old point, but I do wish that god, who is almighty after all, was sometimes asked to fix external, visible illnesses as well as internal ones.
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phal4875
The world is run by cats; we just feed them.
04:05 PM on 04/15/2012
You are just seeking the easy stuff. Raising a few people from the dead is the real challenge.
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crydespite
no-one is ever 'just saying'
05:40 PM on 04/15/2012
ha. well spotted. with a control group who they didn't try to raise from the dead. I expect the statistics might be rather dull though.
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Mandalor te Siit
US Congress: 15% approval rating, 90% incumbency
07:18 PM on 04/14/2012
Science cannot prove prayer. To conduct an experiment the first thing you need is a hypothesis. The hypothesis must be arrived at making VERY FEW assumptions. If there are too many assumptions, that amounts to too many variables for the results to prove the hypothesis. Assuming that prayer is anything more than pointless muttering and wishful thinking is making too many assumptions to conduct a scientific experiment.