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David Katz, M.D.

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Minding Our Second-Favorite Organ

Posted: 01/23/2012 8:39 am

As a preventive medicine physician who truly believes "if you don't have your health, you don't have anything," our prevailing behaviors have always been hard to fathom.

The parent who simply can't find time to cook a family dinner can, always, find time to take a kid to the ER or endocrinologist. People who can't afford mixed greens can afford diabetes test strips.

People who carefully and responsibly invest in the financial security of their retirement (although we know that's no guarantee of a good outcome!) routinely neglect altogether any investment in their health. If money can be put aside for future benefit, why can't time be "put aside" -- invested in physical activity, eating well, getting enough sleep? It can be, of course -- but our social norms don't encourage it, and it doesn't happen. A standard-issue, responsible modern adult -- carefully tends their money, and neglects their health. It's normal, and almost expected. But bizarre -- and often calamitously costly.

Many people reach retirement with the money they need, lacking the health they need to use that money for anything enjoyable. As a physician, it is excruciatingly painful to look into the imploring eyes of a retiree who has long anticipated their golden years -- and has cultivated the bank account to underwrite it -- now disabled by progressive diabetes, lung disease, brain disease or heart disease that need not have occurred.

And it is all too common. I have seen, and continue to see, many such patients. Patients who reach retirement age with robust good health and too few dollars come along, too, of course -- but far less often. And here's the news flash: Those with health but not much money are clearly a happier group than those with money but not much health. I have met them on the intimate turf of clinical care, and they have told me so.

This is the backstory for a careful consideration of the Alzheimer's disease crisis we now face.

There has been enormous attention of late to the grim and genuinely frightening problem of Alzheimer's disease. The problem is grim by its very nature -- there is little we contemplate with greater dread than the loss of our minds, our very selves. The problem is frightening at the personal level because we feel vulnerable to this increasingly common condition we don't know how to cure, and at the collective level, where estimates suggest it could cost the nation a trillion dollars annually by 2050. There is also the terrible burden on family members, who must face the high demands of care, compounded by the heart-wrenching loss of a loved one who is still there, yet already gone.

It is in this context that President Obama has declared a war of sorts on this scourge, calling for means of both prevention and treatment by 2025, or even 2020. There is lively debate about how realistic the goal is -- although on that issue, I note that the best way to predict the future is to create it. You don't get to the moon without committing to the trip.

To create the president's future, it will be important to develop new treatments, as it is for obesity and diabetes. But as with obesity and diabetes, it will be important not to let the hunt for breakthrough treatments become the tail that wags the dog.

Alzheimer's is overwhelmingly a vascular disease, and thus overwhelmingly preventable. Estimates are less well established than for other chronic diseases, but it seems likely the risk can be trimmed by nearly 80 percent -- and perhaps eliminated entirely but for the extremely genetically vulnerable -- by minding our general health.

It is only fair and honest to concede that we do not have perfect defenses against Alzheimer's. And, to some extent, we are hoisted on our own petard -- vulnerable to this condition of advancing age because we are better at living longer than ever before.

But the evidence is strong, if not incontrovertible, that whatever the genetic underpinnings, the epigenetics of Alzheimer's -- the exposures that influence how genes behave -- are of profound importance. By and large, Alzheimer's is a vascular disease. By and large, the practices that prevent cardiovascular disease -- eating well, being active, avoiding tobacco -- slash the risk of Alzheimer's.

Study after study after study after study that has shown an elimination of up to 80 percent of all chronic disease with the application of lifestyle as medicine has NOT carved out an exception for Alzheimer's. The evidence that we can alter gene expression with the power of lifestyle almost certainly pertains to Alzheimer's as it does to cancer. By minding our bodies, we can mind our minds, too. We can best mind both, by minding the short list of what matters most to health.

Available evidence suggests that controlling cardiac risk factors can lower dementia risk specifically by 50 percent or more.

So see a doctor at regular intervals to have your blood pressure and cholesterol monitored. High cholesterol can contribute to dementia by accelerating the development of atherosclerosis; controlling blood lipid levels with diet or medication can protect against this. High blood pressure can damage the blood supply to the brain in several ways, and is the leading risk factor for stroke. At least one European study suggests that treatment of high blood pressure all by itself can cut dementia risk in half.

While the scientific evidence linking cigarettes to dementia per se is equivocal, the link between smoking and vascular disease is clear and strong. So avoid tobacco to protect your brain by protecting the blood vessels that nourish it.

There is some evidence to support what most of us have heard about "brain foods." Fish consumption appears to protect brain function, most likely by contributing omega-3 fatty acids to the diet. An omega-3 oil supplement, one to two grams daily, is an alternative. Antioxidants in food appear to be protective as well, contributing to the reputations of blueberries, red wine and green tea.

But while an inventory of potential brain foods can be assembled, the evidence is much stronger for the importance of the overall dietary pattern. Eating well is as important to the brain as it is to the heart. Lower your risk of Alzheimer's with plenty of vegetables and fruits, whole grains, beans and lentils, olives and avocado, nuts and seeds. Limit consumption of highly-processed foods, fast foods, sugar, salt, saturated and trans fat. Physical activity, too, nurtures the health of body and mind alike.

There is some evidence that poorly controlled stress, lack of sleep and various nutrient deficiencies -- vitamin E, vitamin C, and vitamins B12 and B6 in particular -- may increase the risk of dementia. Controlling stress, getting adequate sleep and a balanced diet with or without supplements may all confer protection.

Finally, population studies consistently suggest that those who exercise their brains protect their minds from dementia. Crossword puzzles and Sudoku are aerobics for your brain. Just as physical activity defends the body against aging and infirmity, mental activity seems to help preserve the vitality of the brain. The Mayo Clinic and the Alzheimer's Foundation, among others, provide nice summaries of prevention strategies online.

As we mind our mind by minding our bodies, we can mind our business into the bargain. The price tag of Alzheimer's -- and chronic disease in general -- threatens nothing less than our national solvency. Only prevention can solve that problem. A breakthrough drug for Alzheimer's would be wonderful -- but who is naïve enough to think the drug would be dispensed for free? Serious chronic disease is bad financial news when we can't treat it, and still bad financial news when we can! The financial news turns to the good only with prevention. Lifestyle is not only the best medicine we have -- it is the only medicine we have already available to all, at essentially no extra cost, and without a prescription.

A healthy brain needs clear arteries, a sound heart, clear lungs, fit kidneys, a robust liver. Even if your brain is your second-favorite organ, you can tend it best by looking after all the other less-favored organs on which it is co-dependent.

Altogether too many of our loved ones have Alzheimer's already; and too many more will get it. There is no question we need the government, and big Pharma, and the biomedical community at large to wage the battle of treatment on our behalf.

But prevention is the greater prize in the long run -- and is largely already within our grasp. There is no need to wait for the government, or big Pharma. Take matters into your own hands. Mind your mind and mind your body with the zeal and diligence you routinely apply to minding your own business. Because, they are.

-fin

For more by David Katz, M.D., click here.

For more on Alzheimer's, click here.

Dr. David L. Katz; www.davidkatzmd.com
www.turnthetidefoundation.org


 

Follow David Katz, M.D. on Twitter: www.twitter.com/DrDavidKatz

As a preventive medicine physician who truly believes "if you don't have your health, you don't have anything," our prevailing behaviors have always been hard to fathom. The parent who simply can't...
As a preventive medicine physician who truly believes "if you don't have your health, you don't have anything," our prevailing behaviors have always been hard to fathom. The parent who simply can't...
 
 
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07:04 PM on 01/25/2012
I agree completely that protecting your brain is one of the most important things that you can do. Unfortunately, we live in a society that rewards the least intelligent far more than the educated. Look at the incomes of uneducated athletes, entertainers and criminals. But a mind is still a terrible thing to waste, I guess.
I find it interesting that doctors never talk about some of the primary things that serverely damage our brains over our lifetimes. Fluoridated water with toxic sodium fluoride destroys brain cells and it only gets more concentrated by boiling it. It does not prevent tooth decay. The mercury in vaccines and flu shots is toxic at all levels and destroys brain cells. The mercury amalgum in dental fillings used for decades in dentistry destroys brain cells. Watching too much television and computer screens dulls brain function.
Here are tried and proven methods to keep your mind strong into your later years. Never get any type of vaccine or flu shot. Strengthen your natural immue system with herbs and diet. No mercury fillings. Do not boil tap water. Install a reverse osmosis filter in your home water supply. Reduce your television watching dramatically. Read books or do puzzles, the mind thrives on reading written text verses reading text on a computer screen. Add ginkgo biloba and Omega 3 fatty acids to your daily diet program. And you will stay mentally sharp, just like I am. Protect your mind because no one else will.
06:09 PM on 01/25/2012
EAT MORE HEALTHY ANIMAL FAT
Ignore health propaganda telling you grains and wheat are healthy
01:55 PM on 01/25/2012
I disagree with this author's statement that Alzheimer's disease is primarily a vascular disease. My 75 year old mother has been a vegetarian for the last 35 years, has absolutely no vascular problems (no high blood pressure, no high cholesterol) and has always been very physically active and yet she has Alzheimer's disease. I am sure vascular problems can cause dementia but what my mother has is different. I think asthma medicines and bisphosphonates are at the root of her problem. She took asthma medicine for the first 1/2 of her life. This led to her getting osteoporosis later in mid-life which led to her doctor prescribing a bisphosphonate. I think scientists should investigate this "drug cascade" as it relates to dementia.
01:46 PM on 01/25/2012
I take issue with the author's statement that Alzheimer's disease is primarily a vascular disease. My mother has been a vegetarian for the last 35 years, has absolutely no vascular problems, no cholesterol or blood pressure problems and has remained physically active and yet she has Alzheimer's disease at age 75. This author is simply wrong. I am sure vascular problems cause dementia but what my mother has is different. I believe taking asthma medicines and bisphosphonates for the osteoporosis they caused are the root of the problem and scientists need to do research on this. Will they? It depends on how tied to big pharma they are.
04:33 PM on 01/24/2012
At a month shy of 91 years of age my father came to live with me upon the death of my mother. I would say he had early signs of dementia. He was a physical fitness health "nut" all his life ~~ no junk food, got up hours before having to leave for work so he could go through his extensive exercise routine; kept this up throughout retirement, and played golf 5 times a week; was an engineer, did complicated math for "fun". Kept up his daily walking and exercise routine when he came to live with me. Read the Wall Street Journal and other papers daily. Did crossword puzzles. By the time almost five years rolled by, at almost 96, he was almost non-human from the dementia and thankfully passed away.

He did everything right ~~ except he lived too long. After seeing this up close and personal for 5 years, I would rather have a massive heart attack today than live that long and end up the way he did.
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John Shuck
They are lying to you about who wrote Shakespeare.
01:22 PM on 01/24/2012
This is an article that exaggerates for effect and so, diminishes the very effect it hopes to accomplish. The number one cause of Alzheimer's is living longer. We don't know very much about it yet. A lot remains to be discovered. There has been no link established between "exercising your brain" whatever that means and lowering or delaying the onset of Alzheimer's. Let's encourage healthy living styles without condemning those who don't according to our standards. Eating habits are formed early-ask Oprah. Or Paula. All the propaganda out there is not helping. The food industry isn't interested in promulgating a healthy diet, only in activating the urge to eat so you'll consume more. Diet police, back off!
flkewlkid00
waste is a terrible thing to mind
04:53 PM on 01/24/2012
watching fixnews on a daily basis will cause brain damage in the healthiest of people so why dont you back off and leave the people who want to help others alone.
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madcityy
01:00 PM on 01/24/2012
u got it or u dont........it is all blind luck...................pray for a normal quick death after a long good life.

u have no say in any of it....................GOD PICKS UR TIME TO GOOOOOOOOOOOOOOOOO

U DONTTTTTTTTTTTTTTTTTTTTTT
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Phoenix Lee
12:00 PM on 01/24/2012
the heathen don t like bible study even the old timers there is some preventive medicine in there like in the book of timothy mix water with wine for stomach troubles
11:37 AM on 01/24/2012
I to see the daily life of a once strong individual slipping away into this totally devastating disease, this person being my wonderful father. As I see what once was a person whom never asked for anything in return as he worked daily at his job and sometimes two to support a family of four with his only son battling spina bifida. as he now depends on those around him to basically tend to his every need what happened to that strong individual that daddys little girls looked up to. I have now taken a choice on everything I put in my body. And I search daily for new reports of how this disease can be fought. I hope and pray that the day comes soon that there is a cure found for this disease so that no one else has to go through the pain and sorrow of sitting and watching your love one slipping away from you day by day!
11:12 AM on 01/24/2012
To the question: why don't intelligent adults make intelligent lifestyle choices?, I think the answer is; in the context of our culture, food environment and human psychology, people's choices do make sense. Immediate gratification will usually win over delayed gratification, especially when the immediate gratification is for sure (french fries!), and the delayed gratification is unsure (no guarantees you'll live longer and healthier). Add to that the exquisitely sophisticated marketing of unhealthy lifestyle choices (poor nutrition, entertainment-while-sitting, etc.), it takes strong character to join the resistance. Living in a culture of poor lifestyle, poor lifestyle has become the norm and over time, people begin to cling to it. The antidote is culture change, and that is very hard to do.
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fhmjam
07:26 AM on 01/24/2012
Too many drivers on our highways should pull over and get mentally healthy before starting up their automoblile.
09:25 AM on 01/24/2012
The roads would be empty. LOL
06:10 PM on 01/25/2012
Wow thats where you went with this? Brilliant. You must be a true problem solver.
(not sarcasm lol awesome comment)
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mygiza
10:17 PM on 01/23/2012
Dr. Katz offers some superb dietary wisdom in this article.

Olives, fish and grapes are awesome foods.

Rubin's "Makers Diet" is a must read that complements this information.
http://www.makers-diet.net/
09:23 PM on 01/23/2012
With the fear that is generated about potentially developing Alzheimer's as we grow older, it is so important that this message gets out, that we can (if we choose) reduce our relative risk of Alzheimer's and dementia by getting back to the basics: eating healthily, doing some exercise, keeping our brain stimulated and managing our stress levels. It's not hard and it isn't rocket science.

It is through articles like this that we can all be reminded that in the end we are all responsible for our bodies and minds. There is no pill or treatment that will make the difference.

We perceive change to be hard or difficult and whilst it is true that our brain resists change, which makes changing habits more difficult, the reality is that our super "plastic' brains are perfectly capable of rewiring to produce healthier habits and lifestyles, no matter our age.
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Carolyn Kostopoulos
01:46 PM on 01/23/2012
government can help by ending corn subsidies, which leads to cheap meat and snacks, and forbidding DTC advertising of pharmaceutical drugs, which teaches people that there are drugs to remedy all their excesses. chronic bad health makes money in this country and the companies raking in the dough don't actually care if they bankrupt the nation and cause untold suffering.

but don't look to the government to betray it's corporate masters anytime soon. the best thing you can do to improve your health is stop going to grocery stores. buy real food from a farmer's market. leave your car in the garage an learn to walk again.

turn off the TV and use the time to cook real food with basic ingredients

you'll improve your health and undermine the corporatocracy at the same time. what could be better than that?
12:58 PM on 01/23/2012
Excellent article. Eating Mc Donalds and sitting all day is not worth losing your golden years to dementia.
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06:50 AM on 01/24/2012
Good advice! I think I'll skip watching Obama's Free Campaign Commercial AKA The State of the Union Message tonight (which is a Mess). That's a good start right there!!

"Excellent article. Eating Mc Donalds and sitting all day is not worth losing your golden years to dementia."
07:22 AM on 01/24/2012
There will be lots of dementia and Alzheimers showing up real soon. It may even be a national crisis. This will be proven to be a direct result of listening to years of Obumas false promises. You will be spared because you know enough you turn him off.
Thousands can still be saved if we get him out in 2012.
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joynerz
Commentor # 297,597,634
04:09 PM on 01/24/2012
What's O got to do with your being a dummy? Is he holding your hands to keep you from eating healthy? He's not in the job of babysitting.
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John Shuck
They are lying to you about who wrote Shakespeare.
01:10 PM on 01/24/2012
Is too.