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David Kirby

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CDC Has Lost Control of the Autism Argument

Posted: 04/04/08 01:55 PM ET

On Wednesday, CNN's Larry King hosted Jenny McCarthy, myself, and several others to discuss the growing evidence of a link between childhood vaccines and autism. The CDC refused to send someone to appear on the show. Instead, on Thursday, the agency issued a statement meant to reassure the American public that all vaccines are safe for all kids.

But the CDC statement only served to show how out of touch the administration of George (really? gas costs 4 dollars?) Bush really is.

A recent government decision to award nine-year-old Hannah Poling taxpayer dollars for her multiple vaccine-induced autism, has left parents anxious and alarmed, especially when their own kid has a pending appointment to receive 5 or more vaccines in one sitting (Hannah had 9 at once).

So the CDC now issues a written statement meant to soothe jittery parents, by saying that "the recommended vaccine schedule is flexible." Such decisions, the friendly announcement said, "are best made in consultation with the child's doctor, and parents shouldn't be reluctant to have such discussions."

Of course parents shouldn't be reluctant to have this discussion, but they are. I get nasty emails from some pediatricians, and the number-one complaint I get from them is that, because of people like me, they must now "waste" (their word, not mine) precious billing hours talking to layperson parents about vaccine science.

These doctors' hostility is palpable, (and they hopefully represent a minority of pediatricians). And while I cannot imagine ever consulting anyone of such temperment for medical care in the first place, many parents are simply cowed into silence. For them, the CDC suggestion to ask vaccine safety questions at a well-baby visit is laughable, if not risible.

Interestingly, after years of being told that autism is purely genetic, and not some environmentally triggered epidemic, parents now learn that the CDC has begun a massive investigation, called the SEED study, to look at "genetic, environmental and hormonal factors, as well as selected mercury exposures," that cause autism

This is encouraging news, though one can assume that thimerosal is not among those mercury exposures that have been "selected" for study.

But the real problem here is the track record and credibility of the CDC to continute conducting any vaccine safety studies at all, a view that is shared by some on Capitol Hill.

This is not helped when the CDC continues to issue statements such as:

"Top scientists -- with the open-mindedness that characterizes good science -- planned and conducted the highest-quality, large-scale (vaccine safety) studies. No links to autism have been found."


Now, I have no doubt that CDC officials believe these truly were the "highest quality" studies available. But but many scientists, including some who authored the studies, disagree. They say many of the studies were flawed and/or inconclusive.

THE U.S. STUDY

The flagship study was a four-year analysis by the CDC of a large US database called the Vaccine Safety Datalink (VSD). This study, published in the journal Pediatrics, was authored by Dr. Thomas Verstraeten, a visiting researcher from Belgium.

The final, published version of the study found no evidence of a link between thimerosal in vaccines and autism, though earlier analyses -- discovered through the Freedom of Information Act -- showed remarkable correlations.

At the time, the CDC called it one of the highest quality studies of its kind ever conducted.

But in 2006, Congress asked the National Institutes of Health to convene a special panel to investigate the quality and usefulness of the VSD database -- and by extension, the Verstraeten study itself -- as a means of investigating such a link.

The panel determined that there were "several serious problems" with the database and the study, including many "weaknesses" and "limitations" that could render certain analyses "uninformative and potentially misleading. "

The NIH Panel was "concerned" about how autism diagnoses were made and recorded by HMOs who take part in the database, and questioned if the HMOs had adequate services for autism families, who might seek care elsewhere. Panelists said these and other problems likely led to an "under-ascertainment" of autism cases in the HMOs.

The panel also cited many problems with the Verstraeten study design. It warned that a "large proportion, around 25%, of births were excluded from the analysis." Panelists wrote that these same children "may represent a susceptible population whose removal from the analysis might unintentionally reduce the ability to detect an effect of thimerosal."

Other "serious problems" were the facts that there was no consideration of pre-natal thimerosal exposures from immune globulin, or "other vaccinations given during pregnancy," (i.e., flu shot), and no accounting for, "the cumulative exposure to organic mercurials through diet or other environmental sources. "

The NIH panel determined that these problems, "reduce the usefulness" of the VSD to prove or disprove a link between thimerosal and autism.

Shortly thereafter, panel chair Dr. Irva Hertz-Picciotto, Professor of Public Health at U.C. Davis School of Medicine, told Dan Olmsted (formerly) of UPI that the VSD study "was not the last word... things need to be looked at again, perhaps with different methodology."

And Verstraeten himself said the study proved nothing. In a letter to Pediatrics, he wrote that, "We found no evidence against an association, as a negative study would. On the contrary, additional study is recommended, which is the conclusion to which a neutral study must come."

THE DENMARK STUDIES

Two studies conducted in Denmark are always referred to by the CDC and others when trying to defend the injection of organic mercury into the systems of newborn babies and infants. These are among the best of the "highest quality" studies, we are told, that show no link between vaccines and autism.

The main Denmark study reported that the removal of mercury from vaccines was followed by a sharp increase in reported autism cases. But the authors admitted that much of this increase was possibly due to a major change in the way Denmark counted its autism cases during the study period (switching from inpatient diagnosed cases only, or about 13% of the total, to cases diagnosed in inpatient AND outpatient settings, or 100% of the total).

The CDC touts the high quality of the study, even though the authors cautioned in the study itself that "methodological limitations" -- such as the exponential expansion of patients (due to counting both inpatient AND outpatient cases) -- "may have spuriously increased the apparent number of autism cases."

Adding insult to understatement, Dr. Hertz-Piccotto said that, as bad as the VSD study was, the Denmark papers were even worse. "Some studies are stronger than others," she said. "The Verstraeten study was an improvement on other studies, including the two in Denmark, both of which had serious weaknesses in their designs."

THE IOM REPORTS

In 2004, a committee of the Institute of Medicine reviewed the US, Denmark and a few other similar studies (whose methodology have been questioned in other venues including my book, "Evidence of Harm").

The IOM committee relied almost exclusively on large population studies (epidemiology), and virtually ignored the growing body of evidence emerging from clinical, animal and test tube studies from the fields of toxicology, immunology and other scientific disciplines.

(Interestingly, the US Federal Court system has determined that epidemiology alone is "insufficient" when trying to disprove a link between exposures and outcomes in an individual).

The committee concluded that the evidence did not support a vaccine link to autism. But it added that, "We cannot rule out, based on the epidemiology, the possibility that vaccines contribute to autism in some small subset," something that parents have been saying all along.

Finally, in 2005, another panel of the IOM criticized the CDC for a "lack of transparency" in its vaccine safety programs, particularly the VSD database. The IOM panel report noted that a CDC official had testified that some of the original datasets in the Verstraeten study, "had not been archived in a standard manner," and, "may not allow all the re-analyses that one might want to do, or in fact may not be available at all."

This same IOM committee, citing the Federal Information Quality Act, which makes it a felony to intentionally lose or destroy any publicly funded records, recommended that vaccine officials at the CDC's National Immunization Program "seek legal advice."

And despite all of this (and more) the CDC wants us to believe that these studies represent the "highest quality" analyses available.

The leadership of CDC Director Julie Gerberding has been replete with crushing morale depletion, embarrassing media coverage, congressional investigations into Katrina trailers, and a general sense of an agency in decline.

Sadly, the words "CDC" and "highest quality" can rarely be used in the same sentence anymore.

 
 
 
 
 
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09:39 AM on 04/07/2008
Poling was included as a test case even though her mito condition had been documented as early as february 2006 by Zimmerman et al. This is clearly not a typical case.

Hannah's "autism" appear mild and temporary. According to Zimmerman et al at 23 months she scored 33 on the Childhood Autism Rating Scale (CARS). Her CARS scores dipped below 30 shen she started kindergarten.

I have to wonder why it was included in the Omnibus. For many it appears to be an obvious case of vaccines aggravating a mito condition. But until we are allowed the same access to court documents as Mr. Kirby, who has spent the last few years cheerleading the discredited autism/thimerosal hypothesis, it's too early to link Poling to other discredited hypotheses.
08:15 PM on 04/07/2008
There is no evidence Hannah had mito dysfunction prior to her vaccines on July 19.
11:07 PM on 04/10/2008
More accurately, there was no suspicion of a mito condition prior to her vaccines.
02:31 PM on 04/06/2008
The CDC is a very political organization. If you want to see how they operate, read Hillary Johnson's "Osler's Web" which shows in great detail how the CDC has lied to the American public for over two decades about "Chronic Fatigue Syndrome." If they use the same political antics on autism, everyone will still be running around in hypothetical circles two decades from now.

From the CDC's perspective, the only people qualified to comment on the CDC are CDC scientists. The CDC has almost absolute power in public health and remember how absolute power is said to corrupt.

And don't forget that the CDC never shut down the Tuskegee Syphilis Experiment the minute they found out about it. It took a journalist (tipped off by a public health underling) to move things in the right direction. If they had waited for a qualified doctor to blow the whistle, the experiment might still be going on today.

Public health without oversight and accountability is tyranny.
HUFFPOST SUPER USER
CraigWilloughby
In the immortal words of Socrates, "I drank what?"
02:47 PM on 04/06/2008
"Public health without oversight and accountability is tyranny."

Excellent quote! Thanks for that post.
12:44 AM on 04/06/2008
While it is not unlikely that the autism epidemic has its roots at least partly in environmental factors, there are many potential sources other than vaccination: air pollution, food additives, mercury in our drinking water, household molds ... all these chemical agents and more in our environment are as contemporaneous with the rise in autism as childhood vaccination.

As one who was a child during the horrific polio epidemics of the 1950's I would not want to see these, or the earlier smallpox epidemics strike our cities again because we panic ourselves into curtailing vaccination against these scourges.

To most of today's younger parents with infant children, polio may be little more than an anecdote from ancient history, but it crippled many children for life and even killed some. If polio struck our cities again each summer, I think most people would see preventative vaccination as by far the lesser evil when weighed against the smaller peril of increased autism risk.

That said, it is crucial that further studies on the environmental connection to autism continue. We probably need to be more cautious of vaccination and perhaps limit them to the prevention of life threatening diseases, but we also need to look at other potential environmental causes of autism. If we were to stop vaccinating entirely and leave ourselves vulnerable to a new polio epidemic, only to find that the real culprit in autism is baby food additives, an entire generation of children may curse us.
04:09 PM on 04/06/2008
While it is not unlikely that the autism epidemic has its roots at least partly in environmental factors, there are many potential sources other than vaccination: air pollution, food additives, mercury in our drinking water, household molds ...
Wake up America. We have been under areosol attack(chemtrails) for at least 12 years. The US military, under God knows whose orders, has been spraying us(except Utah) with millions of pounds of toxic spray daily. A spray which includes massive contamination of aluminum and barium particulates, 200 types of mold, MORGELLONS PATHOGENS, exotic strains of bacteria and ETHYLENE DIBROMIDE. All without our permission or knowledge. See http://imageevent.com/firesat/strangedaysstrangeskies.
They(the eugenist) used to be happy to kill us with their made up wars and famines and medicines and food additives but no that was not fast enough so now they spray us right under our noses and we accept it.
Google Endgame
A Jones spells it out for you and yes Mabel, 911,Iraq War , food additives, and vaccines are connected.
12:07 AM on 04/06/2008
It's all about possible lawsuits--if mercury is bad then dentists come under fire too, so with all the recklessness in the name of expediency and profit, there's too many people who've been wronged--and that means civil suits galore. No one can admit wrongdoing, especially in the CDC or the ADA.
11:12 PM on 04/05/2008
By now it should be evident to all that our entire healthcare system has been hijacked by the pharmaceutical companies. No matter what the problem is (or could be), we have the drug (or innoculation) for it.

So along with increased suicides and murders under prozac, lexapro, and the like; ad heart attacks caused by pain and heart medications, we have big pharma killing or torturing our kids - even while they're stil in the mother's womb (waiting to be delivered by C-section).

When your doctor offers you drugs...just. say. no.
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HUFFPOST SUPER USER
klmebane
04:45 PM on 04/06/2008
"When your doctor offers you drugs...just. say. no."

i don't know about that, but you should definitely try other avenues of treatment first... our culture is to quick to prescribe a pill... medication won't cure everything, and over-using it just leads to less effectiveness.
08:28 PM on 04/05/2008
Thank you Mr. Kirby and thank you Huffpo for sharing this important information. I urge all parents, and parents-to-be, to do research on both sides of this issue, so that you can make an informed decision. My own child is one of those who was injured by vaccines. Our pediatrician was completely uninformed & treated us with scorn when we asked questions. When we insisted on his giving our child the "dead" polio vaccine instead of the "live" one (this was in the 90's), he told us "we were making a ridiculous fuss over nothing". In the year 2000, the CDC finally stopped US Drs from giving the "live" polio vaccine to kids and went back to the safer "dead" one. After our child almost died from his third round of vaccines (he actually got whooping cough from the vaccine); we dumped the Ped. and started taking our son to a Family Dr. Also, with the concurrence of two other MDs, who took the time to carefully review our sons case and family history, we stopped the vaccines, except for tetanus boosters. One of my students has autism & his parents firmly believe it was caused by vaccines. They are both scientists for a large drug company!

There are two sides to this issue, people. Investigate them both before you make harsh judgements. This is America, everyone should have the right to make their own decisions as to what is best for themselves and their children.
rrose
progressive and proud of it
06:48 PM on 04/05/2008
"the real problem here is...the credibility of the CDC".
As a journalist and public relations professional, what qualifies David Kirby to pass judgement on, or even assess in any meaningful way, the credibility of the CDC? Just asking....
HUFFPOST COMMUNITY MODERATOR
strifeknot
09:38 PM on 04/05/2008
What are your qualifications for assessing Kirby's assessment of the CDC? Just asking...
11:22 PM on 04/05/2008
strifeknot--a new name

I don't think any here need certain qualifications to read and come up with the same assessment. Do you somehow have a more favorable feeling about CDC?
09:56 PM on 04/05/2008
I believe that the point he is making is that since the CDC did not feel confident enough to make their case in the public square and instead attempted a "political spin", that they must feel that they are thin ice and can no longer control public perception and reaction. They have spent their public reputation defending the indefensible and now they need to back it up with real facts instead of continuing to say "just trust us".
06:33 PM on 04/05/2008
It is the fear of what will happen to the v. schedule that is holding up a resolution of this matter. And that is an overstated and -felt fear.
It's not as if we would be helpless in the face of an onslaught of a return of the ch. diseases if we didn't have the vaccines to protect us from them (with all their side effects). Take polio. Dr Klenner of So. Carolina had begun successfully treating it with v. large doses of vitamin C before the advent of the (patentable) vaccine for it. But with that advent, his treatment quietly disappeared from view. Or take measles. Older GPs will know about successfully treating it with vitamin A/cod liver oil. And there is the likes of colloidal silver in successfully treating the DPT triad - and thus without its litany of side effects (particularly the pertussis component). The list of natural anti-virals and -bacterials goes on; thus ameliorating the symptoms, AND thereby allowing true, lifelong immunity to take place, that the mother can then pass on to her child through the placenta and then her milk. Fortunately the medical profession is beginning to be aware of the dangers of too many children having too immature of an immune system. This may help pave the way for a consideration of ALL the factors involved in a major review of the vaccination issue - a review which the huge increase in autism will have brought into being.
05:48 PM on 04/05/2008
As much as I've had my run-ins with Heraldblog/AutismNewsBeat et al in these autism threads, I want to acknowledge something valuable about that skeptical, Devil's Advocate point of view; viz: where are the studies? Many of us believers in a vaccine connection w/autism have not gotten hung up on the lack of any solid epidemiological studies confirming the link (we have other reasons for our beliefs, eg, clinical, animal & test tube studies, and probably most significantly, the 'anecdotal' evidence of a parent's experience upon having taken his/her child in for their shots & seen a clear result - highpitched screaming, inconsolable crying, going ragdoll limp, etc etc - that incontrovertibly led to some form of ASD/PDD etc); but if the vaccine schedule is going to be threatened over this issue, 'they' want it to be a damn sure thing, evidential as hell. And so those making the claim of a connection have had to do some good hard work - that will benefit us all in the long run, for the information that it has brought out. Info hopefully (from the connection pov) that will (a) force into place a pre-vaccine screening phase, for that subset of children who are susceptible to vaccinal damage, and will (b) put pressure on the medical-pharmaceutical complex for safer vaccines, and (c) a later introduction of them, and without so many antigens at a time
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HUFFPOST COMMUNITY MODERATOR
blindjester
English and ESL teacher
07:48 PM on 04/05/2008
Few people are saying that it is the vaccines that cause the problem. Most maintain that it's the thimerosol preservative that is at issue. If there is a plausible link, even if it is not fully proven, what is the harm in using an alternative preservative? People could keep taking their kids in for shots, but without the mercury.

Maybe it would cost more money. But isn't this the kind of thing we should spend money on---the health of our children?

What would prevent us from taking at least this much action?
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CraigWilloughby
In the immortal words of Socrates, "I drank what?"
08:21 PM on 04/05/2008
Sadly, I think that changing the formulae to this extent at this point would imply liability on the part of the CDC et al. God knows they in no way want to take responsibility for something like this.

I will say this. If they have been poisoning our children, then they'd better fess up now. I'm far more willing to forgive them as opposed to this being leaked out somehow.
08:49 PM on 04/05/2008
Why did I think they had taken the thimerosol out of the vaccines? I thought some states had even banned it 5 or more years ago. And that even if it was in you could ask for thimerosol free vaccines. I used to hear Imus and his wife talk about it. Am i wrong?
04:36 PM on 04/05/2008
Bottom line is that science is often trying to get something positive done and then hubris and money prevent any response beyond we know what is right, until they inevitably admit they are guessing most of the time. Vaccines have a function in healthcare and they also may be overused and present more risk than benefit when preserved with mercury. It is a complex integraative approach that will find better answers. The CDC would benefit from a little humility in their approach and admit that they don't know and that there are alternatives for those who are concerned. Like cigarettes it may be helpful to warn those who get the shots about the "controversy which is under further study" and let them assume the risk with the benefit of a little knowledge. This needs to get fixed by healers with a conscience, not lawyers.
04:36 PM on 04/05/2008
The article is interesting, but I think fails to distinguish what are the responsibilities of the FDA, and
what falls into the domain of the CDC. I suspect most of the blame should fall at the doorstep of
the FDA, which has been very politicized by the current morons in the White House.
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lisakaz
04:31 PM on 04/05/2008
Thank you for providing so much information. I have mercury poisoning and it was diagnosed by conventional docs as MS. I'm on chelation therapy right now and might be improving (it might take 6-12 more months to really know). No one can tell me where the mercury came from; I had only one amalgam filling. Childhood immunizations is one possibility. I have always had some level of clumsiness, and it might relate to the mercury.
04:26 PM on 04/05/2008
This is pretty bad advice. It's "not even wrong".

I don't know what those awful, rude pediatricians wrote you, but it might have been something like this:
If a population is not almost completely innoculated against a virus the virus will survive among the population that has not been vaccinated and continue to mutate.

A kid isn't just vaccinated for their own sake, but for the sake of the community.

Which is why activists and community groups struggled so hard to vaccinate every American against Polio. Anyone unvaccinated put everyone at risk.
This is still a problem. Read about vaccination in Africa. That not only could but would be us if not for near-universal vaccination. Which is why a doctor might be frustrated at rumors which disuade people from vaccinating their children. It's EXACTLY what happens in third world countries bouncing back and forth between irradication and epidemic.

Give money to Autism research.

This is complicated science.

Almost all mainstream scientists agree that global warming is real, despite the fact that this conclusion is against the profit incentive of the oil industry.

If science supported a causal link between a vaccine ingredient or vaccination method and Autism, that knowledge could not be silenced by big pharma.

Especially since the solution would be a different method or formula, rather than the getting rid of the industry.

Most importantly correlation doesn't, ever, prove causation.
HUFFPOST SUPER USER
CraigWilloughby
In the immortal words of Socrates, "I drank what?"
04:49 PM on 04/05/2008
"Almost all mainstream scientists agree that global warming is real, despite the fact that this conclusion is against the profit incentive of the oil industry."

But they fought tooth and nail to discount it.

"If science supported a causal link between a vaccine ingredient or vaccination method and Autism, that knowledge could not be silenced by big pharma."

For many years, Big Tobacco hid from the American Public that their product was deadly and addictive.

"Most importantly correlation doesn't, ever, prove causation."
Correlation is the first step to proving a causation.

Do you guys all use the same script?
09:57 PM on 04/05/2008
But not all correlation leads to causation. I think that was the point.
06:41 PM on 04/05/2008
Wasn't Thimerosal removed from vaccines in 2001 anyway? Certainly if there's a causal linkage between Thimerosal and autism, then anyone injured by it should be compensated. But, what's the rationale for fear now, if the ingredient isn't used anymore?
07:46 PM on 04/05/2008
Check out the CDC's web and look for the page that has the ingredients list. You will see that Thimerosal is still in many of the vaccinations. They like to say it is removed, however you will see otherwise.
04:01 PM on 04/05/2008
Vaccines have a glorious and hideous history. They are the ultimate magic bullet. Miracles when they work.

But the process of making vaccines is fraught with danger of cross species infection.

Read about and watch the video: "The Origin of Aids" and the possibility that HIV crossed over from chimps used to make vaccines in Africa. The destruction of sample evidence applies here too.

Finally, combining vaccines is somewhat new. The immune system may react in unforeseen ways.
04:34 PM on 04/05/2008
What an amazing display of ignorance. Do you subscribe to many other conspiracy theories?
HUFFPOST SUPER USER
CraigWilloughby
In the immortal words of Socrates, "I drank what?"
04:50 PM on 04/05/2008
Is it possible for you to be less rude?
05:01 PM on 04/05/2008
43 years ago, when I was drafted into the US Army, I was given multiple vaccines
for every thing from bubonic plague to yellow fever. My lymph nodes swelled up all
over my body, for about two days, before going back to normal. My understanding,
is that that infants and children's immune systems are not as robust as and adult.
I do think a little caution is in order, but I'd much prefer to discuss this with a
professional.
photo
Erdgeist
per omnia extrema
03:27 PM on 04/05/2008
"children cared for by Homefirst Health Services in metropolitan Chicago have at least two things in common with thousands of Amish children in rural Lancaster: They have never been vaccinated. And they don't have autism." And I would say the sample is huge. So is the CDC just plain stupid or just malevolent?
04:55 PM on 04/05/2008
The Amish of Lancaster Country vaccinate, and some of their children present with symptoms of autism. Your assumption is based on a three year old article by a former UPI reporter named Dan Olmsted. He wrote an article called The Amish Anomaly, in which he claimed to have scoured the hills and dales of Lancaster Country looking for signs of autism, and found only one child with the condition.

But Olmsted had never called or visited the Clinic for Special Children in Strasburg, PA, which holds a weekly vaccination clinic. The clinic also sees dozens of Amish children who, like Hannah Poling, have "autistic like symptoms."

I would not say that anyone who still believes Olmsted's Amish myth is "just plain stupid or just malevolent", but I do have to question why anybody would take a UPI story as gospel.
HUFFPOST SUPER USER
CraigWilloughby
In the immortal words of Socrates, "I drank what?"
05:23 PM on 04/05/2008
Believe me Ken, we would never take anything you say as gospel
photo
Erdgeist
per omnia extrema
07:07 PM on 04/05/2008
Heraldblog: Total garbage! Have you read Dan Olmsted's rebuttal to your claims? Olmstead did in fact visit the clinic many times. Nor does Dr. Strauss admit to seeing cases of ‘idiopathic autism’. Dr. Strauss said, in fact, "My personal experience is we don’t see a lot of Amish children with idiopathic autism. It doesn’t mean they don’t exist, only that we aren’t seeing them at the clinic." So people who don't follow Olmstead's trail are either just plain stupid of malevolent.