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Dr. Michael J. Breus

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Unraveling the Mystery of Why We Sleep

Posted: 08/02/10 08:00 AM ET

It's a simple question that you'd think would have a simple answer. We know that sleep has restorative effects on our bodies down to the cellular level, but how it all works from a biological perspective has been somewhat of a mystery.

Now we've got more details to help tell the story of just what exactly goes on. New research suggests that during the initial stages of sleep, energy levels increase dramatically in brain regions that are active when we're awake. The scientists behind this latest study believe that this surge of cellular energy may replenish the brain's processes that we need to function normally during the day.

"Energy," by the way, refers to ATP (adenosine triphosphate), which is our body's chief energy molecule. It's also the same energy currency in other animals like rats, which were used in the study. The researchers found the following:

  •  ATP levels increased in four key brain regions that are normally active during wakefulness, when the rats were in non-REM sleep.
  • During this time, however, an overall decrease in brain activity occurred.
  • When the animals were awake, ATP levels remained steady.
  • When the rats were gently nudged to stay awake three or six hours past their normal sleep times, there was no increase in ATP levels.

What does all this mean?  

The authors concluded that sleep is necessary for this ATP energy surge, as keeping the rats awake (depriving them of sleep to mimic a sleep deprived human) prevented the surge. The energy increase may power restorative processes absent during wakefulness, because brain cells consume large amounts of energy just to perform daily waking functions.

Indeed, there's a lot to do when we're awake. In addition to all the tasks we complete consciously, think about all the things we do practically subconsciously like breathing, think about things we do almost on autopilot: surfing the net, walking the dog, sometimes even driving a familiar route.  All this activity requires--you got it-- the ATP energy that appears to be produced by a good night's sleep. And a good night's sleep is exactly what the doctor ordered to prepare us for the rigors of our day. No sleep, no energy expended in the brain to help us recover from the day and, in essence, recharge our minds for the next adventures of the next day.

It's also worth noting that the precise mechanics of the brain also remain a mystery to some degree. There's no doubt that the brain requires a lot of energy to function as the body's master of ceremonies. We already know that sleep loss can actually result in brain loss. In fact, the obligations of the brain may be the only reason we need sleep: because without a brain the body isn't worth much. And it certainly can't do much.

In addition to food, water and oxygen, the brain clearly needs sleep. If only sleep-deprivation were as compelling of a sensation as feeling famished or thirsty. We always seem to be able to put off sleep. But eating or drinking, well...

Sweet Dreams,

 

Michael J. Breus, PhD

The Sleep Doctorâ„¢

www.thesleepdoctor.com

 
 
 

Follow Dr. Michael J. Breus on Twitter: www.twitter.com/thesleepdoctor

It's a simple question that you'd think would have a simple answer. We know that sleep has restorative effects on our bodies down to the cellular level, but how it all works from a biological perspect...
It's a simple question that you'd think would have a simple answer. We know that sleep has restorative effects on our bodies down to the cellular level, but how it all works from a biological perspect...
 
 
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04:51 PM on 08/04/2010
The reason I sleep is because of articles like this.
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09:20 AM on 08/04/2010
This article hints that the purpose of sleep may be as simple as replenishing the brain's supply of something called ATP.
If we go on the assumption that the only purpose of sleep is to replenish a chemical balance within the brain, then the possibility arises that at some point we may discover a way to artificially restore that chemical balance, without the need for sleep.

Given that laboratory experiments with rats were conducted that led to the conclusion concerning the amounts of ATP in the brain before and after sleep, perhaps at some point experiments will be conducted to test ways of introducing ATP into the brain artificially?

In the meantime, it seems that we are left with the dictum, "I sleep, therefore I am."
07:49 AM on 08/03/2010
"We always seem to be able to put off sleep" Not me. If I don't get a full night of sleep I'm a hopeless zombie. Can't think, can't pay attention to anything, crabby and feel like crap.
When I think of sleep deprivation I think of Henry Kisinger who claimed to only need two hours a night. Did you ever look at the man's eyes? He always looked like he was about to fall over. Maybe if he had gotten some sleep he would have made better policy decissions and a lot of people would have not been killed in Indo China.
08:18 PM on 08/02/2010
Why do we sleep? Uh, because we're tired?
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Renee Libby
06:45 PM on 08/02/2010
I sleep because I am tired.
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dbishop76
Left of liberal Texan.
06:31 PM on 08/02/2010
And next week, solving that perplexing conundrum of why we go to the bathroom....
08:18 PM on 08/02/2010
Lmao
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HUFFPOST COMMUNITY MODERATOR
M4dwoman
There's a hole in the bottom of the sea
05:13 PM on 08/02/2010
I want the job of nudging the rats.
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rougebaisers
05:07 PM on 08/02/2010
Mmmmmm sleep.
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booki
01:32 PM on 08/02/2010
i have always been an " 8 hour girl."
i used to work for American Airlines, and i realized at a young age , that i was not proficient, if i skimped on my sleep. i had so many responsibilities., not to mention.....
the security alert issues..
that is one great aspect of the Airlines. .....if u know, u r going to out..
they are lenient, insofar as u getting someone to cover for u the next day..
as long as it is approved prior. by a supervisor..
i love sleeping and i love dreaming........ that is the only place i see my parents.
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Goodnews77
10:53 AM on 08/02/2010
Why the Right Amount of Sleep Is Important
We all know that sleep is important to us. It allows our body to rest and lets our brains process information that our senses receive during the day. So, understanding how to get a good night’s sleep is extremely important. After all, we spend about a third of our lives asleep! A number of sleep problems have been directly linked to other health problems. [...]

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