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Gary W. Small, M.D.

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The Coming Epidemic of Alzheimer's Disease

Posted: 09/25/10 09:00 AM ET

I felt so close to Larry and admired him so much, that I had failed to even consider dementia as a possibility. I didn't want either of us to go through that pain. There are treatments, even cures, for depression, paranoia and obsessive-compulsive disorder. But we only had symptomatic treatments for dementia that could help for a while. Eventually, every patient got worse and succumbed to the disease ... My psyche wouldn't allow me to consider the worst--that he could literally be losing his mind--even though it was right in front of me. Unconsciously I must have feared that if someone like Larry could get dementia, then so could I.

--From "The Naked Lady Who Stood on Her Head: A Psychiatrist's Stories of His Most Bizarre Cases"

I know that my sense of helplessness about Larry's illness is shared by many who witness those they care about develop Alzheimer's disease. Advances in medical technology have allowed people to live longer. The average American woman can expect to live to age 79, while the average man may anticipate living to 72. In addition to these gains in life expectancy, 80 million baby boomers--people born between 1946 and 1964--are entering the age of concern, and age is the greatest risk factor for developing dementia. For people age 65 years and older, the risk of getting the disease approaches 10 percent; for those 85 years or older, that risk nears 50 percent. So we're living longer, but not necessarily better--we're facing an epidemic of Alzheimer's disease in the next decade.

Just mentioning the "A" word evokes fear and dread in baby boomers who have seen the illness afflict their parents' generation. This most common form of age-related mental decline has an insidious onset of symptoms that seem to sneak up on victims so gradually that it's almost imperceptible. Initially mistaken for normal age-related forgetfulness, the short-term memory lapses slowly become so disruptive that patients can no longer care for themselves. Eventually it not only destroys memory and thinking abilities, but patients have a change in personality -- often becoming agitated, aggressive, paranoid and psychotic. Families become unable to care for them at home, and they can end up in long-term care facilities.

The age wave of seniors at risk for Alzheimer's disease is not just a U.S. phenomenon. A considerable economic burden augments the emotional and practical challenges we face worldwide. According to the Alzheimer's Disease International report on the global economic impact of dementia, the estimated worldwide costs in 2010 of both informal care (from unpaid family members and others) and the direct costs of medical and other social care totals $604 billion. This figure accounts for approximately one percent of the world's gross domestic product. If caring for dementia were a company, its annual revenue would exceed that of Wal-Mart ($414 billion).

Scientists are searching for more effective treatments, and many of us have focused on developing early detection tools, using brain scans and blood tests so that we might be able to develop a vaccine or medication that lowers an individual's future risk or can stave off the onset of symptoms. But we don't yet have an anti-dementia drug that eradicates the mental symptoms of Alzheimer's disease, the way an antidepressant medicine may help someone with major depression live a normal life or an antibiotic can cure a pneumonia. This lack of a disease-modifying treatment is what accounts for the fear factor that makes it hard for people to face the reality of the diagnosis.

To deal with this coming epidemic, dementia needs to become a health priority. We need to invest in research to discover more effective treatments. Data from the UK suggests that we need a 30-fold increase in funding to reach parity with cancer research. We also need to overcome our fear of the disease and get proactive in seeking care. Often patients and families wait until the patient is in the moderate to severe stage of the illness before seeking a doctor's care. Although current treatments have only temporary effects, they can make a tremendous impact on the lives of patients and their families, reducing the costs of other medical care and keeping patients in their homes, functioning at higher levels, for much longer. In my experience, the earlier people get help, the better their overall outcome.

I couldn't cure my friend's Alzheimer's disease, but I was able to help him with his symptoms. He started medicines early, made plans for his future while he still could, and enjoyed his life while his mental faculties held up. I only wish I could have offered him more. Perhaps the realization of the coming epidemic will motivate us to overcome our fear and denial, and invest in a solution. What do you think?

Follow me on Twitter at drgarysmall.

See my new book, "The Naked Lady Who Stood on Her Head: A Psychiatrist's Stories of His Most Bizarre Cases."

 
 
 

Follow Gary W. Small, M.D. on Twitter: www.twitter.com/@drgarysmall

I felt so close to Larry and admired him so much, that I had failed to even consider dementia as a possibility. I didn't want either of us to go through that pain. There are treatments, even cures, f...
I felt so close to Larry and admired him so much, that I had failed to even consider dementia as a possibility. I didn't want either of us to go through that pain. There are treatments, even cures, f...
 
 
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03:50 PM on 10/11/2010
Early diagnosis and intervention will be key to managing the increase in Alzheimer's and other forms of dementia. There are several paper-based tests that can provide a “first pass” screening for memory impairment: http://bit.ly/91Vb9K MyBrainTest.org
10:11 PM on 09/29/2010
Hope all the public policies the boomers have enacted will protect them.
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loki
cheap politicians for sale
09:28 PM on 09/29/2010
check out curry. No joke. I was told this by some guy in a store, and we started my mother, diagnosed with Alzheimer's 6 years ago. Within 4 months she started to regain memory, become more aware and has been improving ever since. It was no quick results, like I said, took 4 months before we saw any results, but she had been on a couple medications costing over $400 a month for years without any noticeable results. Is it a mix of Curry and the meds? dont know as she is still on the meds, but the curry is cheap, and it basically takes one tablespoon with her food twice a day , every day to get these results.
Theres a ton of info on this on the web too if anyone is interested.
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HUFFPOST BLOGGER
Gary W. Small, M.D.
Director, UCLA Longevity Center
10:37 PM on 09/29/2010
That's great that your mother has improved with her current regimen. We're hoping to sort out whether curry is causing such improvement or whether it's something else. The only way to do that is to compare the active treatment (curry spice or curcumin supplement) with an inactive placebo.
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majorwood
My micro-bio is empty, just like my wallet
02:07 PM on 09/28/2010
I lost my father to AD August 27th after he lost the ability to swallow food and water. He was 84. Dad's mother died from it at 93 in 1993. Dad's brother also succumbed to it about 3 years ago. I've been saying for a while now that an epidemic is coming. Certainly we are seeing the start of it right now. The cost is going to be enormous, not just in what it costs for the actual care of the patient, but what it costs his loved ones and especially his caregiver if that person is a family member. Watching a loved one perish over a 5/6 year span is very difficult and will effect all aspects of your life. Currently Medicare does not cover long term care costs for AD. Forget about the insurance companies too. Their only interest is their profits. If ever there was an argument for universal health-care this is it. Statically speaking, by age 85, half of congress will be afflicted with some form of dementia, AD being the most common. A cure for AD would be wonderful, but prevention is probably more realistic. India seems to have a very low incidence of AD. Maybe that's a good place to start looking.
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brooklyncitizen
Soror quaerens lucem
01:20 AM on 09/29/2010
My condolences.
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HUFFPOST BLOGGER
Gary W. Small, M.D.
Director, UCLA Longevity Center
06:45 AM on 09/29/2010
Thank you for your comments about your own family's experiences with this devastating illness. I agree that India is a good lead since the incidence is lower there compared to the U.S. Our group has been studying the curcumin in their popular curried food and has found that it is a potent anti-inflammatory and anti-amyloid agent (amyloid plaques are deposited in the brains of Alzheimer's victims). We are planning a clinical trial to test a form of curcumin that we think penetrates the brain and might stave off the disease in people at risk..
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majorwood
My micro-bio is empty, just like my wallet
09:02 AM on 09/29/2010
I can't help but wonder if I might be a candidate for such a clinical trial.
04:40 AM on 09/27/2010
Modern medicine has failed us. We have increased our life span, but not our brain span. It's sad to know that currently, there is no medical treatment that prevents or cures Alzheimer's Disease. Preventative measures are the only way to starve off Alzheimer’s disease.

Alzheimer's disease has increased five fold in those over 65, and 12 fold in those under 65 in the past fifty years, despite medical advancements and tripling of our standard of living. By the year 2050, an estimated 40% of 65 year olds are likely to reach 90. Most Americans reaching 65 today have Clinical Predictors of Alzheimer’s Disease. There are clinical predictors that can greatly increase your likelihood of getting Alzheimer’s or decreasing your likelihood.

I want to share this helpful article about the clinical predictors of Alzheimer's Disease that can hopefully help in the prevention of Alzheimer's Disease: http://www.ladolceliving.com/medical-conditions/is-it-alzheimer-s.html
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HUFFPOST BLOGGER
Gary W. Small, M.D.
Director, UCLA Longevity Center
07:09 AM on 09/29/2010
Thank you for sharing this helpful article. I am optimistic that modern medicine will make some headway especially with the strategy of early detection and prevention. At UCLA, we have developed the first brain PET scan that demonstrates the physical evidence of Alzheimer's disease, both the amyloid plaques and the tau tangles (http://www.ncbi.nlm.nih.gov/pubmed/17182990), and we are finding that we can observe the build-up of these abnormal deposits decades before symptoms are obvious. That means that we have tools that will allow us to target people for prevention treatments before symptoms are severe. Of course, we need more research to find the drugs and/or vaccines that will stave off the disease.
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HUFFPOST SUPER USER
LukeTunyich
Biomechanics and Health
05:12 PM on 09/26/2010
Quote:
“So we're living longer, but not necessarily better--we're facing an epidemic of Alzheimer's disease in the next decade.”

We are not only facing an epidemic of Alzheimer's disease in the next decade but for the last three decades, we are witnessing the epidemic of dementia, including Alzheimer's disease.

The rising trend of incidences of Dementia including Alzheimer's disease can’t be attributed to the small increase in relative life span.

Quote:
“Advances in medical technology have allowed people to live longer.”

The rising standard of living is responsible for the increase in relative life span. As the relative life span has increased in last a few decades, (I am not sure but) it seems to me that the absolute life span has decreased. (More people are reaching 80 years of age and on the other hand, less people reaching 90 years of age).

Luke Tunyich

BiomechanicsandHealth.com
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HUFFPOST SUPER USER
katmeyster
We don't have a spending problem.
02:15 AM on 09/26/2010
I don't have the references in front of me, but I understand there has been research that indicates Alzheimer's may also be related to insulin and hormone imbalance -- I've even heard it called Diabetes 3. It makes some sense that a disease of civilization like Alzheimer's could be related to new ways of eating, food, and environmental toxins our ancestors were not exposed to. I also saw an interview with a doctor who did not cure her husbands Alzheimer's, but reversed some of the symptoms, by using Coconut Oil.

Anyway, there is a lot of research beyond what you hear about in the news.
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HUFFPOST BLOGGER
Gary W. Small, M.D.
Director, UCLA Longevity Center
11:28 AM on 09/26/2010
People with diabetes do have an increased risk for developing Alzheimer's disease. Using coconut oil as an Alzheimer's cure has never been proven in a controlled study against a placebbo.
07:03 PM on 09/25/2010
the earliest detection for any condition, that maybe developing in the subconscious ,is pulse diagnosis NADI VIGYAN in Maharishi Ayur Veda

funding for research should be directed to practitioners of alternative medicine or integrative , functional medicine , mind/body medicine , information and energy medicine

i had commented about a previous blog about Alzheimer : it isnt a disease ,it is like damage ; sickness doctors can manage but damage [ entropy ] needs something deeper than the biochemical level doctors are on

the comment it isnt a disease it is damage wasnt posted by the moderator
06:53 PM on 09/25/2010
{{ Patrick McGean
Director
Cellular Matrix Study
Body Human Project est. 1999 }} posted comment on another huffpost blog about ALZ indicating sulphur deficiency as a cause of alzheimer. i dont know if this has been researched by anyone

maybe DR Hyman etc has info about this and other essential " organic " minerals+ vitamins needed for brain health

DR Hyman's blog today about need for a healthy gut in order to remain healthy maybe helpfull

some years ago L-Dopa bean from india was recommended but doubts about whether it could cross the blood brain barrier

whether the book " dying for a hamburger " is right; i dont know

someone in england [ a organic farmer and scientists he hired ] had linked mad cow to organophosphate fertilizer which caused the neccessary copper in prions to be replaced by manganese

for someone with money maybe $600 per day go to Lancaster Mass. or Fairfield Iowa Maharishi ayur veda clinic for vast improvement in quality of life

several MDs who are maharishi Ayur Veda experts are teaching ayur veda to other MDs

the most cost effective program for overall health and well being in any situation is Transcendental meditation (TM) ;'
MDs and PHDs can testify to this : http://www.doctorsontm.org/ on the basis of research and experience
05:48 PM on 09/25/2010
Alzheimer’s is a truly frightening prospect.

For those who are at risk or have been diagnosed with Alzheimer’s or other degenerative diseases, Healthy Aging Clinic Boston has extremely accurate and precise methods of early detection, treatment, and real-time monitoring of treatment efficacy. We are particularly skilled at detecting and treating latent disease.

For more info, visit: http://bit.ly/Healthy-Aging
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BobDeMarco
Founder, Alzheimer's Reading Room
03:28 PM on 09/25/2010
The Alzheimers Reading Room has clear, concise, usable news, research, insight and advice for the entire Alzheimers community.

The website focuses on those suffering from Alzheimers disease and Dementia, Alzheimers caregivers, and the art of Alzheimers caregiving.

100 Million people have been touched by Alzheimer's disease, and 35 million are worried about Alzheimer's.

http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html
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Gary W. Small, M.D.
Director, UCLA Longevity Center
11:29 AM on 09/26/2010
Thank you for reminding us of this helpful resource.
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Mother77
02:57 PM on 09/25/2010
I have been wondering about why and when this has become so epidemic? Is it in our environment or from our behavior of sitting in front of tv and computer screens, from eating additives and preservatives or a combination of all of the above? Why do some live to 100 and are as sharp as a tack while others check out at 60? These are the starter questions, I am sure, but I can't be alone in asking them?
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Kim Stagliano
Author All I Can Handle I'm No Mother Teresa A Lif
08:24 PM on 09/25/2010
Flu shots laden with mercury and dosed to every elderly adult for the last decade+?
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Doybia
11:52 PM on 09/25/2010
I've wondered about mercury fillings in teeth. My mother never took any flu shots, but she did spend a good many years, about 50, with mercury fillings. She never had any of them replaced and I know they deteriorate with age.
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Gary W. Small, M.D.
Director, UCLA Longevity Center
11:32 AM on 09/26/2010
We need to keep our minds open to the many possible contributing factors. Genetics contributes to risk but environmental factors are clearly important as well. I am hopeful that if we continue to focus our research efforts, we will come up with more answers.
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Kim Stagliano
Author All I Can Handle I'm No Mother Teresa A Lif
12:23 PM on 09/26/2010
Wow, Dr. Small - thank you for not spanking me. I was pretty certain I'd get the standard, "There's no evidence of harm that injecting mercury into humans has any danger at all." I agree - we need to look at all possible causes and every known neurotoxin that is routinely dosed to Americans (from pre-natally to elderly) deserves to be under the microscope of scientific inquiry. Thanks so much. KIM
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amdachel
02:41 PM on 09/26/2010
On August 3, in a U.S. Senate hearing on children's health, http://epw.senate.gov/public/index.cfm?FuseAction=Hearings.Hearing&Hearing_id=1ab3cf42-802a-23ad-4a3a-686da83bf6d0
a panel of experts testified that toxins in the environment are the cause of the explosion in the autism rate. Still, millions are spent looking for the genes that supposedly cause autism. Toxins seem to be affecting the most vulnerable--the elderly and the youngest among us--yet no one considers this a health care emergency.
Anne Dachel, Media editor: Age of Autism