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Glenn D. Braunstein, M.D.

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Evaluating the Clinical Effectiveness of Acupuncture

Posted: 10/11/10 03:30 PM ET

If someone starts talking to you about meridians, they're either brushing up on their geography or about to launch into a discussion about the medical efficacy of acupuncture. If it's the latter, and you're a traditional scientist, you might be in for a heated discussion.

Acupuncture 101

Most people know something about acupuncture; mainly, that very skinny needles are inserted into various areas of the body. In Traditional Chinese Medicine (TCM), treatment is applied to the meridian (channel) that governs the site of the pain, not necessarily the place where the pain is being experienced. Ch'i, the invisible nutritive energy that flows from the universe into the body at any one of 500 acupuncture points, is conducted through the 12 main meridians in (ideally) an unbroken circle. Meridians conduct either Yin energy (from the sun) or Yang energy (from the earth). All maladies are caused by disharmony or disturbances in the flow of energy. Acupuncture treatment is meant to realign or reharmonize these disturbances, and on a more elevated level, to enable the realigned cells to unite with the cosmic energy of the universe.

You don't have to have to have graduated medical school to see that this can be difficult to reconcile with modern science. And this is the heart of the problem. Acupuncture is a pre-scientific paradigm based on concepts with no counterpart in contemporary western medicine. Its treatments are founded on philosophical constructs, subjective impressions and responses to patterns of disharmony, whereas Western treatments are the result of controlled scientific research. Putting acupuncture under a microscope can be like trying to capture a spirit out of the clouds.

But before the commenters start typing wildly, let me say that there has been a fair amount of research that demonstrates acupuncture's efficacy. Nevertheless (a word you see a lot in acupuncture research summaries), the conclusion of most studies, or of organizations reviewing the results of clinical trials, is that there was insufficient evidence to recommend for or against acupuncture, or that the results were equivocal, or that further research would be required.

Testing the Tests

This is a result of the difficulty in creating an appropriate controlled, double-blind testing situation. Acupuncture is an invasive treatment, so it's hard to design an effective placebo control group for a study the way standard double blinding practices are used in trials for new drugs. Acupuncture is also a process, not a pill. A process has a lot of variables, including the influence of the acupuncturist, which is a major factor. Blinding both the acupuncturist and the patient as to the treatment being given is a challenge. To rectify this, the "sham" acupuncture placebo was developed, where needles are inserted, but not in the accepted acupuncture points, or not inserted at all (using retractable needles that just appear to be penetrating the skin).

Even with these efforts, as the Institute of Medicine has acknowledged, it's difficult to standardize a process and to separate the effectiveness of a treatment from that of the person providing it. True Traditional Chinese Medicine acupuncture is tailor-made for each patient based upon the condition and the examination, and there are multiple variables such as manual or electrical stimulation, number of acupuncture sites treated, frequency of the sessions, and length of treatment. Additionally, many of the trials suffered from low numbers of subjects and mixtures of conditions rather than examining a single homogenous condition. For example, headache trials often include patients with tension headaches, migraines, headaches due to cervical spine disease and other causes, each of which may have a different cause, and, thus, unlikely to respond to a "one size fits all" approach. On the upside, the quality of acupuncture research is improving. Still, the evidence for and against continues to grow, with many layers of nuance in-between.

Tests such as a positron emission tomography (PET) scan have shown that treatment with genuine needles, as opposed to the use of "sham" needles, does create objective changes in brain states. But, random placement of placebo needles also had that effect.

Where acupuncture seems to have gained the most clinical ground is in the area of pain reduction. Researchers in Germany conducting acupuncture trials for patients with chronic low back pain found that only 15 percent of subjects who received genuine acupuncture treatment needed extra pain medication, compared with 34 percent who were receiving "sham" treatments, and 59 percent receiving conventional therapy. Long-term pain reduction was also best for subjects who received either real or "sham" acupuncture versus those that received conventional therapy.

In another study, researchers used "sham" acupuncture controls entirely and compared it to the drug Effexor for relieving hot flashes in breast cancer patients. They found that acupuncture relieved hot flashes as effectively as the drug and with fewer side effects, namely the lack of energy and reduced sex drive.

So which is it? Does acupuncture work or not? Or does it work if you think it works? While some findings support acupuncture's efficacy, especially for post-operative or chemotherapy-induced nausea and vomiting and post-operative dental pain, others posit that its clinical effectiveness depends mainly on a placebo response.

Proponents of acupuncture say that it doesn't matter if a placebo effect is at work or not because the ultimate goal is to activate the body's power to heal itself. This, in fact, seems to be the point at which Western medicine and the relatively new approaches of Integrative Medicine (IM) or Complimentary Alternative Medicine (CAM) finally do converge. Over the past decade, integrative care has become an accepted element of treatment at many major medical institutions and part of traditional academic curriculums. It combines conventional Western medicine with holistic treatments like acupuncture, massage, biofeedback, yoga and stress reduction techniques to treat the whole person, not just a disease.

In this expanding holistic universe, acupuncture is a key player, even though scientists and scientific institutions continue to question the existing data and testing methodologies, which, of course, is the most scientific way to deal with the issue. The quintessential scientist, Einstein, noted that finding the right question is 95 percent of finding the solution. In the case of demonstrable clinical outcomes for acupuncture, perhaps the best question we have so far is, "Does it make you feel better?"

 
 
 
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02:52 PM on 10/13/2010
Yin and Yang when applied to medicine are ways to describe physiological processes in the body. Yin has to do with cold/rest/fluids/nourishment and Yang has to do with heat/activity/movement. An imbalance of Yin and Yang is akin the body not being in a state of homeostasis. And reharmonizing the body means getting the body to obtain a state of homeostasis. One aspect of Qi can be seen as air or oxygen flowing in the blood and helping to convert ATP in to "energy". These phenomenon were observed by the Chinese over 2000 years ago and they called it Qi. Science has only discovered these processes in the last 100 years.

And as for placebos, it's as possible to create a placebo for acupuncture as it is for surgery. How does one create a double blind study of having an appendix removed? Instead, why not use herbal medicine? It'd be easy enough to gather a group of people all diagnosed with Liver Qi Stagnation and see if the formula Xiao Yao San works compared to a placebo to treat Liver Qi Stagnation. Also, instead of testing effectiveness, why not test the concepts to see if they are valid? Is a harmonized state Yin and Yang a valid way describe a state of homeostasis?
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Halsey
"There is a price to pay for speaking the truth. T
01:27 PM on 10/13/2010
I remember one session with a very good acupunturist (after a very bad head-on collission). She hit some nerve that was like amazing. It was like cocaine without cocaine. Some wonderful endorpine (sp?) went to a happy place. I said "mark that spot!".

I have chronic tension headaches, started with TMJ and have just gotten much worse. Of course I'd rather use acupunture than narcotics..not get my insurance company to cover it!
04:13 PM on 10/12/2010
Yin refers to the shadow side of the mountain and Yang refers to the sunny side.

The description/explanation offered is more of the romantic/energetic view. I try not to use that with my patients...there are some physiologic effects that occur. Some times this works for people other times not, that is no different than any other therapy.
01:44 PM on 10/12/2010
If acupuncture needs to have more studies conducted to determine if it works then why is it being used until we have conclusive results? Ethically this is a problem. At what point do we conclude that there is no legitimate evidence? If results of acupuncture use are no better than placebo then why use it at all? Placebo can not do anything other than affect pain and mood. It can not cure disease.

What is expanding and contracting energy?
04:02 PM on 10/12/2010
"What is expanding and contracting energy?"

Seriously? Wherever fundamental dualities are observed, and there are sort of a lot of them: hot-cold, light-dark, day-night, summer-winter, male-female (physical characteristics), inhale-exhale, nucleus-electron shells, Big Bang-black hole (or whatever the concentrated point of the universe is called before the big bang). If scientists actually have discovered right or lefthandedness in the universe or a DNA molecule, the ancients are nodding their heads (metaphorically) in agreement.
lastpost
see biography
12:01 PM on 10/12/2010
“finding the right question”
Doesn’t the body detect incursions, and respond with its own inbuilt defence mechanisms?
For example, deep wounds prompting the release of pain killing chemicals to permit escape from the danger zone. If insertion of a small needle were to trigger that “traumatic injury” response. Wouldn’t that suggest a way in which this treatment might function?
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Mother77
11:59 AM on 10/12/2010
Acupuncture is not a placebo. I had a radiating pain from ear to teeth and the doctors said possible shingles. The acupuncturist treated my ear and I became well. Also, I had a second experience, more severe, of a ruptured cyst and was treated by acupuncture. Certainly not a recommended procedure by regular doctor standards. I recovered rapidly without heavy antibiotics. I am forever appreciative of my acupuncturists for their care.
ThatsTheTheWayItIs
religion, ideology, partisanship are delusional
10:37 AM on 10/12/2010
About 25% of symptom relief from prescription drugs is due to placebo effect.
Compared to 40% relief from the actual drug. Most of prescription drugs effect is placebo.
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William Diaz
Passive-Aggressive word salad tossed here!
09:56 AM on 10/12/2010
Dr Braunstein,

I am a grad student working in the neural control of beta cell biology (pancreas). I have given the idea of accupuncture and the placebo effect a great deal of thought in relation to my studies. I believe it is real, a physiologically relevant and important phenomena and can probably be tested under controlled circumstances.


I read somewhere that NASA was doing work on voluntary neural control of metabolism for future Mars missions. Everyone has forced themselves to breathe deeply to control an extreme emotional state. If you can figure out the neural connection, you can control it.

Have a great day!
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MalleusMaleficarum
Global nomad.
08:15 AM on 10/12/2010
This column underscores the crisis of western medicine. For centuries, western scientists have been singing their own praises for discovering the field of anatomy, the circulation of the blood and the cell. However, they fail to recognize that all of their discoveries were known to ancient science that was ejected by the dogmatists of the Middle Ages. That the Chinese and other ancient cultures discovered the Meridian System and the circulation of a low level of electro-magnetic energy that courses throughout the human body is a concept that has yet to reach Glenn D. Braunstein and a host of highly paid consultants and doctors. The denial syndrome is especially acute in America. In Europe, alternative medicine embraces many more Chinese methodologies than acupuncture, but all are based on the concept of "energy medicine." At 64 years of age, I have experienced acupuncture circa 6 times -- and every treatment was extraordinary. During one treatment, the practitioner inserted a fine needle into a point on my back, and I felt a flow of sensation from that point to my left wrist. After the session, the practitioner showed me the chart for that channel -- the lung channel. That was merely one of many similar experiences that I have had with my own very limited exposure to acupuncture. The Meridian System does exist, and it is a shame that Western Science has yet to develop a technology of its own to map it and to treat it.
07:30 AM on 10/12/2010
This is really interesting to me because yesterday I had a discussion with high school students about the placebo effect. The first word each student used was "fake." The placebo effect is quite real, which seems worthy of real study in its own right. The procedure is fake. It seems almost as if we have been brainwashed into thinking that something that isn't scientifically verifiable isn't real. If acupuncturists are getting a placebo effect with no side effects (unlike all drugs, I believe, listed in the PDR), it would seem a good place to begin, rather than end, a study. Also, I would point out that if an acupuncturist made a mistake about the most basic of terms in western medicine, such as confusing viral and bacterial infections, as Dr. Braunstein had done here with yin and yang, he would be ridiculed and dismissed out of hand. And using the earth and sun as literal rather than metaphorical representations of yin and yang is misleading in a way that seems meant to connect the terms to primitive cultures. A better definition would be simply contracting energy (yin) and expanding energy (yang).
04:49 AM on 10/12/2010
Firstly, you've got your yin and yang backwards. Secondly, suggesting that Chinese medicine is not based on scientific research conveys an ignorance of Chinese history and current research. The Chinese are very keen on research and have been for centuries. Chinese medicine concepts were researched, debated among academics, altered and then underwent further observation. Currently, acupuncture and Chinese herbs are used in integrated hospitals and the Chinese regularly publish the results of their finding in peer reviewed journals. To suggest Chinese medicine is some quaint little endeavor does not give credit to a highly impressive history. The Chinese understood the circulatory system a thousand years before it was understood (and given credit to) in the West. Endocrine hormones were being isolated a thousand years before it was even understood in the West. It's a fanscinating and rich history which should not be undermined.
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03:34 AM on 10/12/2010
Pre-scientific treatments remind one of religion. Not amenable to proof or it's opposite and largely reliant on faith. Science as a way to knowledge tries vigorously to disprove hypotheses about the nature of reality. To be scientific such hypotheses must always be amenable to disproof. Those hypotheses that resist disproof are provisionally accepted as reasonable working knowledge without ever acquiring the status of truth or dogma as they always remain vulnerable to the death of replicated disproof. Critical Rationalism is the philosophy that underpins scientific method. Science deniers don't know that they don't know that disproof is science's principal endeavor.
01:53 AM on 10/12/2010
I've had acupuncture done, and it was effective - effective in increasing the acupuncturists' bank account. Didn't do anything for me.

Mine was done by a Japanese doctor, who had studied in China and written up in newspapers and journals, said to be the best acupuncturist in the region, and credentialed in Japan and the US. Not knowing anything about the proper training and credentials for an acupuncturist, I went by the testimonies of several acquaintances who swore that he was the reason they were walking.

I had polio as a child and have serious lower body joint problems and significant pain. After spending hundreds of dollars in 6 sessions with the acupuncturist, who had guaranteed results, I felt no difference at all. It was never apparent to me that anything had happened except that I got stuck with a lot of pins. Most didn't hurt at all, and none hurt a lot. But neither did they accomplish anything.

When I complained to the acupuncturist that there was no difference in pain or my ability to walk normally, he told me that my attitude wasn't in the right place, but if he continued treatment long enough, eventually I would get better anyway. He wouldn't specify just how long or how expensive that was going to be.

Maybe acupuncture has real validity. I've heard of Chinese surgeons operating with it in lieu of anesthesia. But I wonder if some acupuncture "cures" or improvements are just another form of faith healing.
12:46 AM on 10/12/2010
Excellent article, Dr. Braunstein. The efficacy of acupuncture or any medical treatment is a product of its measured influence on the patient (validity) and the repeatability (reliability) within the population. Anecdotal reports and inconsistent remedies do little good in establishing a treatment's viability for the general public. My insurance company surely isn’t buying it even though they support chiropractic with its many legitimacy issues.
Every article I read ends the same, “more research is needed.” When do you think a definitive study will be conducted that can either give us acupuncture as a supportable medical tool or define it as just another placebo?
12:33 AM on 10/12/2010
There exist certain medical protocols like Chinese medicine of which Acupuncture is a part which while not Western in origin are nevertheless scientific in that these systems are based on theories or sets of theories which have internally consistent methods of finding data or information about the patient’s illnesses and which have internally consistent methods of differentiating symptoms and of treating an infinite combination of symptom patterns. In the end Chinese medicine is based on empiricism, or in other words, it is based upon what works.

Acupuncture is not made-up as you suggest, and Western biomedicine is less scientific than you presume it to be. Both systems share more than you might imagine as the human physiology remains the same regardless of geography or medical protocol.