SAN DIEGO — Jason Marquis is leading the majors in walks, but it really hadn't caught up to him until Tuesday night.
Marquis came into Tuesday night's game against Philadelphia with a 9-2 record and had won eight straight decisions over his last 11 starts.
But the San Diego right-hander walked five batters for the third time this season, including two in a three-run fifth, and gave up a three-run homer to Domonic Brown in the Padres' 6-2 loss to the Phillies.
"It's just one of those days," said Marquis, who has 53 walks and has had four or more in 11 of his 16 starts. "I just wasn't able to get a feel for anything and I paid the price."
Marquis (9-3) went just 4 1-3 innings, giving up six runs on six hits, walking five and striking out four to lose for the first time since April 22 against Milwaukee.
Brown hit his 20th home run, a three-run shot in the third inning, and tied his career high with four RBIs after drawing a bases-loaded walk from Marquis in the fifth.
It was in the fifth that Marquis walked both Ryan Howard and Brown on eight pitches and also uncorked a wild pitch before exiting his shortest outing of the season.
"I just tried to find a way and battle through," Marquis said. "Sometimes you are able to do that and sometimes you're not. Today was one of those night's I wasn't able to."
Kyle Kendrick (7-4) went eight innings for the Phillies, allowing two runs on seven hits, striking out six and walking none.
The Padres had scored two runs off Kendrick in the bottom of the second, but Jimmy Rollins walked to lead off the third and stole second. He went to third on a one-out single by Michael Young.
Marquis struck out Howard, but Brown hit a 2-and-0 fastball 411 feet into the right-center stands to give the Phillies a 3-2 lead.
"I was looking changeup," said Brown, "It was the only fastball I had seen from him in three at-bats. So I was just trying to hit something in the middle the other way and I just reacted to the ball. I just wanted to keep the swing short and quick and made that adjustment."
Brown said that manager Charlie Manuel had talked with him at batting practice about making some adjustments.
"It was a fastball, up and out over the plate," Marquis said. "It's 2-0 – a hitter's count – and he put the barrel on the ball."
Kyle Blanks singled to right for San Diego in the second and Yasmani Grandal doubled to left. Alexi Amarista's infield grounder to second scored Blanks, and Pedro Ciriaco's single to left scored Grandal.
The Padres threatened in the ninth on Grandal's single and Ciriaco's third hit of the game, a double. But reliever Antonio Bastardo struck out Logan Forsythe for the final out.
"That home run by Brown was big particularly after we gave up two and to come back and take the lead," said Kendrick.
NOTES: Padres LHP Robbie Erlin (1-0, 4.15 ERA) will be called up from Triple-A Tucson on Wednesday and will make his second major league start against Philadelphia. "We like we saw when he beat the Blue Jays. He's getting to a point where he's about to break through," said Padres manager Bud Black. LHP Cole Hamels (2-11, 4.50 ERA) will pitch for the Phillies in the final game of the series. . Padres 2B Jedd Gyro, on the DL with a right groin strain, flew to San Antonio on Tuesday and will play with the Padres Double-A team Wednesday and Thursday. If all goes well, according to Black, Gyorko would be activated and would join the team Friday in Miami ..Padres 3B Chase Headley batted cleanup Tuesday for the second straight day. However, Black said he will likely not stay there even if he heats up. "We were hoping a different look would give him a different perspective on the game. I don't think it had anything to do with him getting two hits (on Monday).". Phillies 1B Ryan Howard returned to the starting lineup after sitting out Monday's game with a sore left knee. Howard was batting .432 over his last 12 games with three home runs and 11 RBIs. . Phillies RHP Carlos Zambrano is scheduled to make another start at Triple-A Lehigh Valley on Friday before the club makes a decision whether to call him up. Zambrano, who last pitched in the majors for the Miami Marlins in 2012, is 1-0 in three starts with Lehigh Valley with a 3.18 ERA, 17 strikeouts and nine walks in 16 innings.