PHOENIX — San Diego left-hander Eric Stults got himself in trouble right away and never really recovered.
Arizona right-hander Randall Delgado found an early groove and never lost it.
The combination set up an ugly night for the Padres.
Delgado tossed a three-hitter for his first career shutout and the Diamondbacks roughed up Stults early while pounding out 17 hits in a 10-0 rout over the Padres on Friday night.
"They beat us in every aspect tonight and sometimes that happens," Padres third baseman Chase Headley said.
Stults (8-9) pitched well his previous three starts, allowing five earned runs in 21 innings, and tossed a two-hit shutout his last start against Arizona on June 14.
The Diamondbacks roughed him up right away Friday.
Aaron Hill drove in a run with a double in the first inning, then scored on Martin Prado's run-scoring single.
In the second inning, Cliff Pennington scored from first when San Diego catcher Nick Hundley threw wildly to first on Delgado's sacrifice bunt and Hill followed with a second RBI double before leaving with a tight right hamstring.
The Diamondbacks scored two runs again in the third inning, on Wil Nieves' run-scoring through a drawn-in infield and an RBI double by Cliff Pennington that made it 6-0.
Cody Ross, who later hit a solo homer, added a run-scoring single in the fourth inning off Stults, who allowed seven runs – five earned – on 11 hits and struck out five.
"I didn't give us a chance to win from the start," said Stults, winless his last five road starts. "The first inning to give them the two runs, then in the second inning to not come out and give us a shut-down inning, that was tough."
It may not have mattered the way Delgado (3-3) was pitching.
One of the top pitching prospects in baseball, Delgado arrived in Arizona with Prado last year in a six-player deal that sent outfielder Justin Upton and infielder Chris Johnson to Atlanta.
Delgado failed to make Arizona's rotation out of spring training and opened the season at Triple-A Reno, where he worked his mechanics and his strike-throwing mentality.
Since being called up in June, the 23-year-old Panamanian has been a solid addition to Arizona's staff, allowed three earned runs in all eight starts.
Delgado worked 5 2-3 scoreless innings his last start, a 3-1 win over San Francisco, and was even better against the Padres.
Everth Cabrera lined his first pitch of the game for a single, but the right-hander retired nine straight until Hundley's leadoff double in the fourth. Delgado stranded him at second and retired 10 straight before walking Yonder Alonso with one out in the seventh.
Right fielder Gerardo Parra made a spectacular catch against the fence to rob Will Venable of a hit to end the seventh and shortstop Didi Gregorious made a diving grab for the game's final out, helping Delgado extend his scoreless streak to 14 2-3 innings.
Delgado struck out three, walked one and threw 70 strikes in 100 pitches for his first complete game in the majors.
He also had a pair of singles, becoming the first Arizona pitcher with a shutout and a multihit game since Randy Johnson on Sept. 14, 2003, against Colorado.
"This is a key for the pitchers, throw a lot of strikes, try to be ahead in the count," Delgado said. "That helped so much today. I was just trying to keep the ball down, throw a strike and see what happens after that."
NOTES: Arizona C Miguel Montero missed his fourth straight game with a stiff back and is still day to day. ... Alonzo went 0 for 3 to end an 11-game hitting streak at Chase Field, second-longest by a Padres player at Arizona's home field. ... LHP Tyler Skaggs, who will start Saturday against San Diego, is 0-1 and has allowed nine earned runs in eight innings in two career starts against the Padres. ... Padres RHP Andrew Cashner, Saturday's starter against Arizona, has not allowed a home run in eight straight starts.