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Jill S. Brown

Jill S. Brown

Posted: February 28, 2011 05:44 PM

Is Aerobic Exercise the Antidote to Alzheimers?


It's almost impossible to turn the exercise-averse or fitness-phobic couch potato into a workout-aholic. Believe me I've tried. No amount of touting the benefits of regular exercise, from looking and feeling better, to reducing risk factors of diabetes and cardiovascular disease has made a permanent difference in the behavior of people who just don't like to break a sweat. Maybe because there's plenty of drugs or common surgical procedures like angioplasty and bypasses to manage these diseases that these people may think, "I'll just cross that bridge when I come it." (Mom, are you reading this?)

Well, there is one disease that scares the be-jeezus out of most everyone who's ever seen it up close and there is no drug or surgery that really works on it yet. No, I don't mean the "c-word," although exercise has shown benefits in that area too. I'm referring to dementia and the big "A," Alzheimer's disease. Sofa slugs, pay attention here: Aerobic exercise is panning out to be the best antidote we have to neurocognitive decline.

Deep in the center of our brains lies the hippocampus. It's the part of our brain that is essential to memory and learning. As we age, the hippocampus shrinks and the older we get, the faster it shrinks to the tune of 1 percent to 2 percent a year, contributing to memory loss and risk of dementia or Alzheimer's.

Arthur Kramer, the director of the Beckman Institute and a professor of neuroscience at the University of Illinois in Champaign-Urbana authored a new study published in the January 31, 2011 issue of the Proceeding of the National Academy of Sciences which theoretically finds that "aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood, which is accompanied by improved memory function."

The study was comprised of 120 Americans in their late 50s to early 80s. Researchers randomly assigned half to an exercise group walking three times a week for 40 min. aiming for their target heart rate. The other half was assigned to a stretching group doing yoga and toning type exercises and they also served as the control group. Both groups were given MRI scans to test for changes in the hippocampus. The test results showed the hippocampus increased by 2 percent in the aerobic walkers after a year but shrank by 1.4 percent in the control group.

Giving a whole new meaning to the term, "gym rat," Kramer said in a recent interview on NPR's Science Friday, "the research we've done with humans is based upon a number of years, over a decade's work of research with animals, mostly rodents. And we know from the animal research that if you give an animal access to running wheel, and it uses it, that there are a number of changes in the brain, and the area that's been examined, probably most intensely, is the hippocampus."

This study isn't Kramer's first foray into trying to prove that physical fitness fosters brain power. In 2003, Kramer co-authored a report titled, "Fitness effects on the cognitive function of older adults: A Meta-Analytic study." (Psychological Science March 1, 2003 vol. 14 no. 2 125-130) I've also previously blogged about this topic on HuffPost "Anti Aging for Your Brain."

It's tough getting non-exercisers motivated. I hope this expanding arsenal of research will get more people to realize regular exercise is not just good for an expanding waistline.

Feel free to share your thoughts!

 

Follow Jill S. Brown on Twitter: www.twitter.com/jillbrownfitnes

 
 
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12:12 AM on 03/08/2011
Another compelling reason to exercise! Jill, I wonder if any among the walking group also lost any weight? In other studies, obesity is also associated with a 'shrinking brain.'

ps My mom is 87 and what most people would consider a 'gym rat.' She also meditates daily --also known to increase brain size-- and shows no signs of any cognitive slowing. We all need role models, and she is certainly mine!
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Jill S. Brown
Fitness trainer & expert - 20 years of experience,
04:00 PM on 03/09/2011
Hey Wendy, you're mother is an inspiration to us all! I wish she lived in NJ and could be a mentor to mine. Great to hear from you!
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10:34 PM on 03/05/2011
What was the target heart rate for the test subjects?
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10:32 PM on 03/05/2011
Thanks for the article. It gives me a bit more motivation to get that daily exercise, which I can be sort of casual about.
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HUFFPOST BLOGGER
Jill S. Brown
Fitness trainer & expert - 20 years of experience,
05:28 PM on 03/07/2011
Hi Roudy,
click on one of the links in the article to take you to the study. I don't recall an exact HR target, but they did have to be in an aerobic zone, so not just leisurely walking but not at the anaerobic threshold either.
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w84it
06:10 PM on 03/03/2011
Great article! I used to work with senior citizens and the elderly. Those who exercised regularly and had very active lives were alert, healthy and mobile. Those who had not exercised or lived active lives experienced a significant decline in mental alertnes, mobility and overall health...especially after 70 years of age.
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babybelle
PureBread Mutt LOL
08:21 AM on 03/03/2011
Walking up and down stairs for 15, 20, 30 minutes or more is a great aerobic workout.
09:23 AM on 03/01/2011
I for one am grateful for the significant amount of research being conducted on Alzheimer’s disease. The funny thing is, even if aerobic exercise is not the “…best antidote we have to neurocognitive decline”. It would do all of us Baby Boomers a world of good to get up and start moving. In my opinion, more research should be focused on early detection. Families who know a loved one is likely to develop Alzheimer’s disease can begin to plan for their long term care. They can also prepare for the eventual role that will play as a caregiver for that loved one. That preparation should include training to deal with the emotional and physical stress that comes with the role.

Ed Caracappa CEO AtGuardianAngel

www.issueswithalzheimers.com
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defortier
Editor of Brain Today Blog.
07:15 PM on 02/28/2011
I applaud the message in this article.

We have known for sometime that diabetes, hypertension, obesity, and high cholesterol are all risk factors for cognitive decline. We have also known that each of these conditions can be somewhat managed through physical exercise. However, neither the threat of poor physical health nor the threat of poor cognitive health has been a compelling motivator for the most sedentary among us.

Now, with evidence about a more direct link between physical exercise and the health of the hippocampus, maybe the message will resonate more deeply. We discuss the "brain-healthy" benefits of exercise and other risk-reduction strategies on a daily basis at the Brain Today blog: www.braintoday.com