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Jonathan D. Moreno

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Bird Flu Blues

Posted: 12/21/11 12:25 PM ET

Some of the hardest questions in the process of scientific discovery aren't about science, but philosophy.

A good illustration of this truism is the unanimous recommendation by the National Science Advisory Board for Biosecurity (NSABB) that two leading journals not publish certain details about experiments with a version of the H5N1 virus, also known as "bird flu."

The board's concern is that the information about the experiments, which involved genetic mutations that made the virus much more virulent than the versions seen in nature, could lead to a bioterror weapon. But the reaction by the editors of the journals Nature and Science to the proposed de facto censorship of research results was, as described by a Washington Post report, "chilly." An expert not on the NSABB was quoted as saying that that the recommendation was "ridiculous" because the risks the results present to humans are remote.

The board's recommendation doesn't go directly to the journal publishers, scientists or their institutions (one is the University of Wisconsin, the other in The Netherlands), but to the Department of Health and Human Services (DHHS), which in turn can only urge the journals to withhold information. One sticking point that gives the U.S. government leverage is that the research in both institutions was apparently done using federal funds. But the U.S. surely doesn't want to look like it's trying to keep the data to itself.

Beyond these short-term calculations, the incident reveals a deep philosophical divide about biological research that could threaten national security and public health, one that I have observed for years as an unpaid advisor to several government agencies including the NSABB (but not having to do with the current studies): How risk-averse should the life sciences community be in an era of asymmetric warfare? In the twentieth century nation-states found biological weapons to be pretty useless and unmanageable, but non-state actors and rogue states might still find them of interest.

Unlike physicists, whose modern discipline grew up in an atmosphere of the deepest possible relevance to national security during World War II, the culture of life scientists is not so woven in with security concerns. An interesting exception was scientists' self-imposed mid-1970s moratorium on recombinant DNA research, but that didn't last very long and didn't involve terrorism fears but rather environmental risks. Obviously that has changed somewhat since the October 2011 anthrax attacks, but international treaties have imposed successful prohibitions on novel development of biological weapons (BW) since 1970. The most extensive effort to develop innovative BW was the secret and illegal Soviet program that continued right up to the end of the cold war. Further complicating the picture is the fact that quite a bit of funding for biology has resulted from post-9/11 worries, particularly in the form of secured laboratories for research on potentially dangerous pathogens.

Still, the default position of biologists is usually that more publicity is protective rather than threatening, that in the long run secrecy works against security rather than for it. Published results, it is generally thought, will help the scientific community and responsible authorities prepare for threats that might be posed by new knowledge well in advance of any actual attempts to use them.

Aiming at a compromise, before accepting the NSABB recommendations the two journals have asked for detailed plans from government that would enable "responsible scientists" to have access to the experiments' details. How such a program would operate, especially in the hotbed of shared information created by the Internet, is not at all clear. What is clear is that the biological science community is very far from adopting anything like a "prudential principle" that would put the burden of proof on those who say there is no risk to a new source of knowledge.

 

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10:55 AM on 12/22/2011
A great perspective. See my further comments at http://judithasanders.com/one-bird-flu-over-the-coockoos-nest/
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HUFFPOST SUPER USER
Planarama
Common sense will one day prevail.
11:50 PM on 12/21/2011
Why was the US government funding research into creating a super-flu? Over the past twenty years I have heard several conspiracy theories about the US government creating and releasing AIDS. Now, today, I am a not so sure it is just conspiracy.

Why would one even try to create such a virus? Just to see if they could do it?! WTF! Why not see if you can jump out of an airplane without a parachute instead? At least then you wouldn't be endangering more than half of our species.

As if we weren't having enough problems in this world already. 60% of people who catch this flu will likely die and no one will be immune. Oh wait, let me guess, the corporations will create a vaccine, release the virus and charge us all a bazillion dollars for it.

Money is just paper you know, corporate overlords. Is it really worth threatening humanity over? What will money be worth is more than half of us are dead?
accelerando
my micro-bio is empty
03:54 PM on 12/21/2011
All those new security agencies gotta find stuff to do to earn their big salaries somehow.
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yatahayaz
03:31 PM on 12/21/2011
When I saw this on the Newshour last night I was speechless. They interviewed the scientist in charge and asked him why, and he replied that he just wanted to see if he could do it. Come to find out the entire study was funded with taxpayer dollars. How morally, ethically, and spiritually corrupt. Just more totalitarianism from a government that can now lock us up and throw away the keys without charges or trial.
I saw how this movie ends, and it ain't pretty folks.
ByAndForThePeople
and corporations aren't people!
02:35 PM on 12/21/2011
Security by obfuscation is at least as bad as no security at all. It gives a false sense of security and provides cover for those who don't want to do the difficult work of real security. But facts that are discovered by one person or group can be discovered by other people and groups.
jhNY
Mercy.
12:43 PM on 12/21/2011
I'm no scientist whatsoever by a long shot absolutely and for sure, but it seems to me that whether or not the details of the mutation process are published now, that the most threatening detail has already been disseminated: the ease with which it was possible to create the mutation.

To me, 'ease' in this context likely means-- with ordinary lab equipment, following the most likely assumptions as to what methods would be successful, scientists were able to cause the disease to mutate into more virulent, more easily transmittable forms.

Whether the details of the processes are published or not, there are dozens if not hundreds of labs in a great many places throughout the world wherein the mutations could be developed, and now a few will likely be so employed, to the increase of our collective peril.

After all , how hard can it be if it's easy?