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Keith I. Block, M.D.

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How Diet Affects Cancer

Posted: 06/14/10 08:00 AM ET

Diet affects cancer both directly and indirectly. Nutrients directly impact the mechanisms by which cancer cells grow and spread. They indirectly help control the cancer by changing the surrounding biochemical conditions that either encourage or discourage the progression of malignant disease. The bottom line is that what you eat can spell the difference between conquering your disease and having it rage out of control.

Here are some examples of findings from recent studies that support the importance of diet in fighting cancer:

  • Diets high in fat and refined carbohydrates make you more likely to become overweight, which in turn increases your risk of tumor recurrences. (8) Obese men are at significantly greater risk of developing more aggressive prostate cancer. (9)
  • Dietary fats can impair the body's anti-cancer defenses by depressing the activity of natural killer (NK) cells, while a low-fat diet markedly increases NK activity. (10,11,12) Natural killer cells play a key role in preventing metastasis.
  • Obese breast cancer patients are two to four times more likely to experience a recurrence than women of normal weight. (13)


For every additional 10 percentage points of calories derived from fat in the diet of newly diagnosed breast cancer patients -- by going from 25 percent to 35 percent of calories from fat -- the risk of recurrence approximately doubles. (14) An increase of 10 percentage points is alarmingly easy: just add four ounces of beef, four ounces of mozzarella cheese (about the size of three nine-volt batteries), a cup of ice cream, or four pats of butter to your daily intake and you're there.

High intake of many dietary fats is linked with higher rates of cancer recurrence, lower rates of survival, or both. (15) At the American Society of Clinical Oncology meeting in 2005, I listened to a stunning presentation of a randomized controlled study of 2,400 breast cancer patients. It found that those who adopted a diet in which 20 percent of the calories came from fat (the US norm is more like 35 percent) had a 24 percent lower rate of relapse. The lowered risk of relapse was particularly great for the 42 percent of women with the more dangerous estrogen-receptor-negative breast cancers. Because these women have fewer good conventional options, this is an especially important finding. (16)

Despite this overwhelming evidence for the benefits of a healthy diet when you are fighting cancer, that is not what mainstream medicine recommends. Yes, when it comes to cancer prevention, the American Cancer Society recommends a diet that is heavy on fruits, vegetables, whole grains and low-fat proteins while restricting unhealthy fats, refined carbs and fatty red meats. So far, so good. Yet the standard advice for patients with cancer -- that is, those for whom prevention didn't work -- is "all you can eat." (17)

Cancer patients are told to get all the calories they can, from butter, margarine, high-fat dairy products, mayonnaise, eggs, meat, hard and soft cheese, ice cream and peanut butter. The rationale is that a fat- and calorie-packed diet prevents or combats cachexia, the "starvation response" seen in cancer patients. It does not. But this response is hardly universal; only some patients become cachectic, and only at certain points in their treatment. The reality is that there are far more patients for whom "all you can eat" is exactly the wrong prescription: it makes them fill their plates with animal protein, saturated fats, unhealthful omega-6 fats and refined carbohydrates, all of which have tumor-promoting properties. (18) In fact, a 2007 study reported in the Journal of the American Medical Association found that stage III colon cancer patients who ate the least meat, fat, refined grains and desserts had half the mortality risk of those who ate the most of these foods. (19)

I don't want to pick on mainstream cancer groups -- in my five years as vice president of the uptown Chicago chapter of the American Cancer Society (ACS), I saw firsthand the good intentions of everyone involved. Nonetheless, the disconnect between the ACS's cancer-prevention dietary advice and its cancer-fighting dietary advice is hard to justify. Even laypeople can see that. A number of my patients have said to me, "My doctor used to advise that I should eat fruits and vegetables and avoid too much meat and fat so I wouldn't get cancer. Now that I got a diagnosis of cancer, I'm supposed to eat cheesecake, milk shakes and cream sauce. That doesn't make sense." They're right: it strains credulity to think that the very foods you are told to minimize in order to reduce your risk of developing cancer should be dietary staples once you have cancer. The cheesecake-and-cream-sauce advice also ignores the growing scientific evidence of the tumor-promoting potential of the standard American diet. To a great extent, the foods recommended for cancer prevention are also the foods that seem to suppress cancer after it's diagnosed. In most cases it is reasonable to use prevention studies as a guide for how patients should eat, especially in cancers where healthy diets reduce risk.


Copyright 2009 Keith I. Block, M.D.

REFERENCES AND RESOURCES

8. Bray GA, Popkin BM. Dietary fat intake does affect obesity: American Journal of Clinical Nutrition. 68(6):1157-73, 1998

9. Freedland SJ, Platz EA. Obesity and prostate cancer: making sense out of apparently conflicting data. Epidemiol Rev. 2007;29:88-97.

10. Hebert JR. Barone J. Reddy MM. Backlund JY. Natural killer cell activity in a longitudinal dietary fat intervention trial. Clinical Immunology & Immunopathology. 1990; 54(1):103-16

11. Malter M. Schriever G. Eilber U. Natural killer cells, vitamins, and other blood
components of vegetarian and omnivorous men. Nutrition & Cancer. 1989; 12(3): 271-8

12. Vujanovic NL. Basse P. Herberman RB. Whiteside TL. Antitumor functions of natural killer cells and control of metastases. Methods (Duluth). 9(2):394-408, 1996

13. Hebert JR. Augustine A. Barone J. Kabat GC. Kinne DW. Wynder EL. Weight, height and body mass index in the prognosis of breast cancer: early results of a prospective study. Int J Cancer. 1988; 42(3):315-8

14. Holm LE. Nordevang E. Hjalmar ML. Lidbrink E. Callmer E. Nilsson B. Treatment failure and dietary habits in women with breast cancer. Treatment failure and dietary habits in women with breast cancer. J Nat Cancer Inst. 1993; 85(1):32-6

15. Gregorio DI. Emrich LJ. Graham S. Marshall JR. Nemoto T. Dietary fat consumption and survival among women with breast cancer. J Nat Cancer Inst. 1985 ; 75(1):37-41

16. Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, Goodman MT, Giuliano AE, Karanja N, McAndrew P, Hudis C, Butler J, Merkel D, Kristal A, Caan B, Michaelson R, Vinciguerra V, Del Prete S, Winkler M, Hall R, Simon M, Winters BL, Elashoff RM. Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. J Natl Cancer Inst. 2006; 98(24):1767-76.

17. Brown J, Byers T, Thompson K, Eldridge B, Doyle C, Williams AM. Nutrition during and after cancer treatment: a guide for informed choices for cancer patients. CA Cancer J Clinic 2001; 51:153-81.

18. Anon. Eating hints for cancer patients: before, during and after treatment. Available at: http://www.cancer.gov/cancertopics/eatinghints/page7#F6. Accessed May 4, 2008.

19. Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS. Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer. JAMA. 2007 Aug 15;298(7):754-64.

 
Diet affects cancer both directly and indirectly. Nutrients directly impact the mechanisms by which cancer cells grow and spread. They indirectly help control the cancer by changing the surrounding bi...
Diet affects cancer both directly and indirectly. Nutrients directly impact the mechanisms by which cancer cells grow and spread. They indirectly help control the cancer by changing the surrounding bi...
 
 
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HUFFPOST SUPER USER
Trittydi
Special on pap smears at Walgreen's this week ....
02:24 AM on 06/16/2010
In addition to the good information here ... please consider spending time at these two nonprofit vitamin D3 advocacy web sites - their goal is to educate the chronically VD3 deficient US public about vitamin D3 benefits:
www.vitamindcouncil.org and
www.grassrootshealth.net

There is a resource library of medical studies over at Vitamin D Council where VD3 was a factor in the study. This includes Cancers, MS, Diabetes I and II, Autism, autoimmune diseases, and on and on. The benefits are staggering. You can't assume your doctor knows - most don't.

There are outstanding videos at Grassroots health by medical professionals on VD3 benefits, including cancer. Up to 90% of 75% of cancers can be avoided or overcome with the help of vitamin D3. It is known that the incidence of chronic disease increases the farther you get from the equator.

Dr. Cannell of the Vitamin D Council says cancer survivors need to have blood serum levels in the 90--100 ng/ml range. It has been determined that toxicity becomes a concern when blood serum levels approach the 200 ng/ml range - so the 90-100 range is completely safe. (Grassroots Health - main page)

Dr. Cannell - Water is more toxic than Vitamin D3:
http://www.youtube.com/watch?v=0oc2Od7Yytk&feature=related

Disease Incidence Prevention Chart by blood serum level:
http://www.radiomartie.com/hot/disease_incidence%20prevention_by_serum_level_chart_0001-1.jpg
*
11:17 AM on 06/16/2010
Amen! D3D3D3D3D3!!!! It can't be said enough.

Also, women, please supplement with iodine and selenium to avoid breast cancer. These items, along with D3, will go a LONG way in preventing cancer.

Cancer LOVES sugar, so avoid it completely! The simple syrup and baking soda trick works against cancer because the concoction acts like a sugary Trojan Horse, sneaking the deadly (to cancer) pH correct baking soda into the cancer cells.

Cancer hates oxygen. Remember that.
04:40 PM on 06/16/2010
Cancer loves glucose, not sucrose.

Cancer hates oxygen? That makes oxydative phosphorylation and ATP generation rather difficult...

I heard cancer hates rock music too.
01:43 PM on 06/17/2010
“Cancer loves glucose, not sucrose.

Cancer hates oxygen? That makes oxydative phosphorylation and ATP generation rather difficult...

I heard cancer hates rock music too.â€
HUFFPOST SUPER USER
healthy blogging
03:35 PM on 06/15/2010
Foods do affect disease onset. An interesting study by conducted by Ellen Gold at the University of California at Davis found that diets high in fruits and vegetables suppressed estrogen a hormone associated with breast cancer. You can read about it here:
http://www.livingfithealthyandhappy.com/2009/12/breast-cancer-diet-tips.html

Furthermore, foods high in fiber and antioxidants (think fruits and vegetables) are effective in combating other forms of cancer. Read it here:

http://www.livingfithealthyandhappy.com/2010/02/reducing-colon-cancer-risk-with-diet.html

Although millions of people are genetically predisposed to developing cancer, environment does play a crucial role. When people are proactive, leading a healthy lifestyle which involves proper nutrition, exercise and stress reduction, it may minimize their risk of disease and/or increase their survival. Thus if a patient ever hopes to recover, it is up to them as well as their physician to be mindful of illness and treatment options.

-healthy_blogging

Published daily, "Living Fit, Healthy and Happy" is a family-friendly health and wellness resource website with articles on fitness, anti-aging, obesity, diabetes, eating disorders, cardiovascular and respiratory health, mental illness and many other health related issues. There's always something for you at "Living Fit, Healthy and Happy".

Living Fit, Healthy and Happy
The website for people who are SERIOUS about leading a healthy life!
08:54 AM on 06/15/2010
Read The China Study by T. Colin Campbell. It basically tells people the same thing. Fresh fruits, veggies, and grains will keep you healthy while a diet high in meat, fats and dairy is a recipe for obesity and disease. I'm a vegetarian of 20 years. Like anything, you have to work at it and I'm not perfect, but when I'm at the grocery store, I'm always amazed at what some people put in their carts. It's no wonder we have so much disease and obesity. I've watched people load their carts with nothing but processed foods. It's gross. If only they could see into the future...

I just got done with a 20 week internship at a nursing facility (AL, long term care and rehab). Lots of illness and disease, mostly with people who did not take care of themselves and they wondered why they had so much wrong with them. Those that did the best took care of themselves all throughout their lives and stayed active -- with a positive attitude. And I was always amazed at the nurses and employees there who continued to eat poorly, smoke and were obese. Apparently they learned nothing from the examples in front of them.
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organicconnect
01:39 AM on 06/15/2010
There is another factor in foods that has to be considered: pesticides. What is being added to vast quantities of food stuffs in our industrialized approach to production are simply put, poisons and neurotoxins. Here's the story of a town in France that confronted this fact when faced with a higher than normal incidence of cancers: http://organicconnectmag.com/wp/2010/01/food-beware-the-french-organic-revolution/
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organicchuck
Man On a Mission
08:24 AM on 06/15/2010
I do wish American consumers would ask questions of organic food producers that is where the answer are, these folks know the differences and what the effect of all these chemicals have on life on our planet. We are connected to the life that lives on our Farms and Ranches, food consumers need to connect with their food sources and it needs to be produced organically. www.rockymtncuts.com
Mark from atlanta
Unity through Diversity.
08:15 PM on 06/14/2010
"...plenty of studies linking meat-eating to cancer, and then jumping to the conclusion that saturated fats are the culprit. These studies are so poor they do not control the most critical variable- the source of the meat."

________________________________________

You raise interesting points regarding the relationship between grain-fed vs grass-fed cows and cancer. However, please realize that a large study would have so many variables as to be pretty much useless. Examples; The pesticides on grains vs grass, pesticides in most grains vs organic grains, hormones injected in some cows vs hormone-free cows, preservatives vs preservative-free meat etc..

There would also be variables in the participants: Would folks who choose free-range cow meat be more likely to make other healthy lifestyle choices such as exercise, not smoking, stress reduction? All of these can lower incidences of cancer.

Instead of producing a plethera of expensive, methodologically questionable studies in a quest to justify meat eating, I think it would be safer for our health (and more environmentally sustainable for our planet) to move toward a meat-free diet.
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organicchuck
Man On a Mission
08:30 AM on 06/15/2010
As a organic meat producers it is important to understand that the days of inexpensive meats are coming to a close. Like many of our food items that are produced in mass, livestock are the worse, and most has been created by consumers lack of interest in food production. This disconnect created a system that is in know way human or sustainable. This is the way it should be done, www.rockymtncuts.com but consumers need to wake up that they are responsible for changing what they eat!!
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HUFFPOST COMMUNITY MODERATOR
editorjuno
Musician, wordsmith, accidental mystic, etc.
07:34 PM on 06/14/2010
Thanks for (apparently) cutting and pasting a piece (actually a book excerpt) from last year, Dr. Block -- fresh info, eh?
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OldTart
Let it begin with me...
08:37 AM on 06/15/2010
And if true, does this reminder to the fickle, attention-challenged, typical American mind prove to be any less true? Your picky point totally misses the gravity of the article and the tragic need for such information to an increasingly sick American public.
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editorjuno
Musician, wordsmith, accidental mystic, etc.
07:46 PM on 06/15/2010
I'm someone who views both conventional allopathy and so-called alternative medicine with roughly equal skepticism -- there are very few involved in the latter who aren't promoting a product or service from which they stand to make some major bucks. Spamming dozens of internet sites with the same old book excerpt strikes me as marketing rather than adding anything new to the available knowledge.

As the spouse of an otherwise healthy cancer survivor who is still severely underweight months after multiple surgeries, devastating radiation treatments, and chemo, I was hoping for something of practical value -- no such luck, and if my wife followed the advice of the organic mulch munchers of Alternative Medicone Inc. she'd probably be dead from sheer malnutrition by now.
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Suntio
Amat victoria curam.
06:41 PM on 06/14/2010
My mother was diagnosed with colorectal cancer in 2002. She had surgery and was declared medically cancer free. To increase her chances of staying healthy, she changed her diet to eat a lot more fruits and veggies, and even went on a 42-day juice-only diet. In 2004 she had to have surgery again, this time her cancer was stage 4, terminal, her tumor was 5 inches long. She had surgery again, and since then she has been following Dr. Budwig's protocol of cottage cheese/yoghurt + flax seed oil + ground flax seeds. Now, 6 years after the terminal cancer diagnosis she is cancer free and declared cured.
01:49 PM on 06/15/2010
By practicing meditation in your daily life rutine, you will reduce the increase of canser, tumor, malignant disease and much more.
Just keep practicing your ISHA YOGA. and you will be fine.
Silvia C Greene
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editorjuno
Musician, wordsmith, accidental mystic, etc.
09:34 PM on 06/15/2010
I'm a big proponent of meditation, but the above advice is dangerous -- meditation is great for helping us endure disease and treatment, but if it actually prevented illness such acclaimed spiritual giants as Ramana Maharshi and Paramahansa Yoganada wouldn't have died of cancer and heart disease, respectively.
04:44 PM on 06/16/2010
Perhaps the overdose of cottage cheese and flax seeds are helping your mother stay cancer free (which is great to hear), OR perhaps the surgeons got the rest of the cancer out the second time.

Anecdotes don't prove theories, they only sound nice.
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mssreader
eat, read, sleep, read and be happy
04:05 PM on 06/14/2010
Thanks Dr. Block for a great article and one that I adhere to. Sometimes you have to listen to your gut, excuse the pun, when you read a lot and have more info than you know how to deal with. I've been a serious health info person for 40 years and after all the advice and info throughout the years, I'm down to the Plant Based Diet-8 years now. I have a lovely BP of 122, slim and my only medical problem is hypothyroid disease that is inherited as both my sisters have it and my daughter though not my mom but I wonder if my father had it because of symptons. He did of lung cancer being a heavy smoker since 16. My mom was 98 last week so I know I have good genes but I'm not going to mess around with those good genes and abuse them. I'm pleased and my motto is that I'm not afraid of dying but I don't want to be sick. No flu in 15 years, and no shots and no cold since the 80s.
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RMankovitz
Researcher, inventor, entrepreneur, author
01:24 PM on 06/14/2010
In my opinion, articles demonizing "fats" are suspect as lacking a foundation in lipid chemistry and nutrition. Is the author talking about omega-3,6,9, or saturated fats? If saturated fats, are they natural from pastured animals and tropical fruit (coconut and palm), or hydrogenated fats, trans fats, interesterified fats, or fats from grain-fed meat?

I know of no study that links natural saturates to cancer or heart disease or any illness. There are certainly plenty of studies linking meat-eating to cancer, and then jumping to the conclusion that saturated fats are the culprit. These studies are so poor they do not control the most critical variable- the source of the meat. It is undoubtedly grain-fed meat, that is loaded with pro-inflammatory omega-6 from corn/soy, along with synthetic hormones and antibiotics from the CAFO industry. There are no studies on the adverse effects of saturated fat as found in nature, but plenty on the positive effects of such fats. See for example:

http://www.health-report.co.uk/saturated_fats_health_benefits.htm

On the other hand, certain low fat diets have a long legacy of promoting cancer, starting with the father of low fats, Nathan Pritikin. He committed suicide rather than deal with his leukemia. Other studies so no benefit. See:

http://www.nytimes.com/2006/02/08/health/08fat.html

An eating plan designed by nature, not nutritionists, can be found in "The Wellness Project."

Roy Mankovtiz, Director
http://www.MontecitoWellness.com
01:52 PM on 06/15/2010
Can you imajen the meat that you eat already containe canser cell and we do not know about it????????
Silvia c greene
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editorjuno
Musician, wordsmith, accidental mystic, etc.
09:38 PM on 06/15/2010
Can you imagine doing your correspondents the courtesy of correct spelling? If you have some sort of handicap that prevents this, I apologize in advance, otherwise please be more considerate or others.
04:45 PM on 06/16/2010
Oh my gosh, are you joking?

How in the world do you honestly think that COW CANCER is going to survive in a human being?

ROFL

I'm gonna use that as a joke...
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justmeinAz
12:49 PM on 06/14/2010
A single point article like this is fine, but the title implies something else entirely. This article should be called How Fat Intake Affects Cancer, because that's the only thing discussed. I would have expected at least four or five different points like this in an article that claims to address how "diet" affects cancer. A small point, perhaps, but the discrepancy did leave me disappointed in the article.
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Wendy Chambers
12:42 PM on 06/14/2010
I totally agree that diet plays a huge part but also the chemicals we use daily like shampoos, deodrants, household products, etc play a part too - organic and 100% natural products and food is the way to go.
10:19 AM on 06/14/2010
I would revise this article to emphasize the distinction between good fats and bad fats. You mention near the end, but someone skimming this article might come to the conclusion that all fat is bad. Most people don't eat enough fish like salmon and snack on chips instead of walnuts, almonds, pecans, brazil nuts, etc. And one other point gets lost in the "low-fat" debate. If your diet is low in fat, it automatically becomes higher in carbs and protein. People on low fat diets often consume a lot of whole grains believing they're good for you, but they're not. As more and more people are discovering issues with gluten and other proteins found in grains, they're realizing just how much better they feel when they cut out all grains from their diet. We tell people to not eat processed food, but how come more people don't realize that grains are processed too? I eat a diet that's probably more than 20% fat. But all of it comes from healthy sources. So do my carbs. It won't surprise me if more and more studies reveal a connection between cancer and grain consumption.
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RhiannonRings
Childfree and loving it!
12:19 PM on 06/14/2010
How about sprouted grains, like Ezekial bread?
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makebofapay
02:14 PM on 06/14/2010
Ezekial bread is great stuff.

The proteins in grains are called prolamins and they are attacked by the immune systems of some people and are linked to things like Celiac disease. Gluten is in many things wheere we don't expect to find it--like soy sauce so read the label ingredients. If you're really sensitive, don't eat anything processed in a plant that handles gluten products. Here are some good substitutes for grains: buckwheat, cornmeal (non-gmo), chickpea flour, brown rice flour, taro flour, sweet potato flour, gram flour.
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OldTart
Let it begin with me...
08:47 AM on 06/15/2010
It does not follow that a diet low in fat automatically becomes higher in carbs and protein. First, define the fat (good fats in olive oil, avacados, canola oil, etc.). That said, I eat a very low fat diet, rich in fresh vegetables and fruits and supplemented with grains that work for people like me with extreme reaction to gluten: quinoa and brown rices (there are a number of varieties). It is important to be tested to understand what works with your body's chemistry (that is, allergies to certain grains, notably wheat and corn, along with other food allergies). When food is fresh, preferably organic (I am blessed to have a large garden and grow my own), and mostly raw the nutritional benefits include a deep satisfaction in flavor and nourishment that prevents overeating. The "typical American diet" needs serious overhaul and that is a formidable task for most people, compounded by the fiercely held biases people hold about favorite foods along with the ignorance.
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vippy
Carpe Diem!
09:51 AM on 06/14/2010
I believe it what he says. I also believe that acidic food hastens the growth!
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Ellamental
Conceptual ambiguist
05:11 PM on 06/14/2010
I'm glad you brought that up - - because my understanding is that our diets (in the U.S.) tend to be measurably acidic because of all the meat and dairy that's consumed. Curious that the article did not specifically state that a more alkaline diet is something to strive for in relation to cancer prevention. The article does say to eat more vegetables (and hence will likely be more alkaline), but it would be useful to explain 'why' that is, and would help to guide people to selecting healthier food choices.

Your body WANTS to be in balance, and an acidic meat and dairy based diet will create imbalance (not to mention 'acid indigestion').

Learn about the pH of foods - it's fascinating stuff.
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vippy
Carpe Diem!
08:50 PM on 06/14/2010
Thank you. I am glad that I am not the only one knowing about the acidic/alcaline balance.
We need to spread it. Doctors are just pushing their meds and sooner or later you succumb
to it because we trust the doctors.
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OldTart
Let it begin with me...
08:50 AM on 06/15/2010
This is a very important point. Using myself as an example: I had severe periodontal disease, requiring painful root planing four times a year. Changing my diet completely to mostly fresh fruits and vegetables, including apple cider vinegar, and setting out to change my body's pH resulted in a total end to the disease in six month's time. It should be mentioned in this discussion that grains are also acid-forming, in addition to meat and dairy.
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megwolff
Plant-based cook & survivor
09:28 AM on 06/14/2010
Great article. Thank you for bringing this much needed information into the mainstream and in your practice.
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rikster
buy the ticket-take the ride
08:06 AM on 06/14/2010
very interesting article. I wonder how the aspects of industrialized food products versus natural (organic)
, and anti-oxidant use to control free radicals measure up in light of Dr. Blocks comments.