Women (and men!) of a certain age who have been diagnosed with osteoporsis are frequently prescribed a bisphosphonate like Fosamax, Boniva, Actonel, Altevia or Reclast. In 2009 more than 5 million prescriptions for these drugs were written. But, as time has gone on, the dangers of long-term use of these drugs causing exactly fractures they were supposed to prevent -- and doing other damage -- have become well-known.
The FDA, which approved bisphosphonates in the first place has backpedaled a bit. Last October the government issued a warning about the increased risk of fractures of the femur -- the thigh bone -- for those who take these drugs for more than five years.
What a quandry for those who need to halt and reverse the bone loss that can lead to "dowager's hump," spinal compression fractures and fractures of the leg. And the number of people who suffer from bone loss is in the hundreds of millions.
Biphosphonates are popular among those whose doctors recommend a medication, possibly because they were the first drugs to be prescribed for building bone. But patients who have read about their drawbacks are afraid to take them for more than a short while, or afraid even to begin. And at the same time these patients are afraid not to take them!
What to do? Fortunately there are drugs other than bisphosphonates that can limit or reverse bone loss. The one I like the best is Evista, though it has side effects too. This drug is a SERM, selective estrogen receptor modulator, and is meant for post-menopausal women. Estrogen is crucial for keeping bone loss and regeneration in balance. SERMs bind to estrogen receptors on bone cells. The cells are fooled into thinking there is estrogen there, so they function like younger bones, keeping bone loss and replacement in balance. The same "trick" works on breast cells and other genital tissue, lowering the risk of breast and reproductive cancers.
Natural Osteoporosis Treatments
But drugs aren't the only answer. Medication or no medication, drinking alcohol and carbonated beverages and smoking aren't recommended, and a diet rich in calcium and Vitamin D is beneficial. Eat lots of vegetables and less red meat. Surprisingly the digestion of animal protein actually takes up some of the calcium bones need. Paradoxically that puts vegetarians and those who don't eat red meat in a good position with regard to bone health. We hear it again and again -- eat collard greens, bok choy and kale. And eat sardines and salmon. Vitamin D is important enough by itself and for calcium absorption that many of my patients take a supplement of 1000-2000 IU a day.
I believe yoga is another valuable tool for everyone's bone health. Not only is yoga weight-bearing. It's the far greater pressure created by one group of muscles opposing another that makes the difference. My clinical trial studying the benefits of yoga for osteoporosis and osteopenia has had significant early success, and it is ongoing now to test those initial results.
During the two-year study, participants added more than 3/4 of a point on the T scale in their DEXA bone density tests for the spine and 4/5 of a point for the hip, which is often the site of a fracture. They did this in one 10-minute yoga session a day. To explain this a little further, participants who had osteopenia improved enough to return to the normal bone density range. Some who had osteoporosis gained bone during the study and entered the osteopenia range.
The people in my study averaged 68 years of age, but yoga would have helped if they were much younger or much older to prevent, halt or reverse the process of bone loss. Eminently portable, quiet and just about free, yoga has few if any undesirable side-effects. Participants in my study did over 20,000 hours of yoga. There was not one injury! There is still room in the study, so if you're interested, you can sign up.
The bottom line
Whether you take medicines or not, you can improve your lifestyle by incorporating natural treatments. As for the medicines, ask questions and investigate, but if your doctor has a persuasive argument, follow his or her advice.
Source:
http://wwwÂ.fosamaxfeÂmurfracturÂelawsuit.cÂom/updatesÂ/physicianÂs-respond-Âto-fosamaxÂ-femur-fraÂcture-studÂies/
Source:
http://www.fosamaxfemurfracturelawsuit.com/updates/physicians-respond-to-fosamax-femur-fracture-studies/
Any comments, Dr. Fishman?
So I have family history, body type, and (unfortunately) years of cigarette smoking and alcohol drinking (not excessively, but I'm not a teetotaler), and because of illness, a number of years of physical inactivity over the last 10 years. Three years ago I was found to also have a parathyroid tumor, large, and I have full-blown osteoporosis in both spine and hip. Just to make matters worse, I have a major problem with GERD, have taken Prilosec for years now -- surgery hasn't been an option up to now -- and that's yet another risk factor.
I'm taking Fosamax, but feel doomed to suffer a fracture. I don't think I could ever eat enough kale to prevent it.
"Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells"
http://www.ncbi.nlm.nih.gov/pubmed/19656492
http://hmg.oxfordjournals.org/content/14/22/3389.full.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001217/
"This review summarises in vitro and in vivo findings relating to the influence of cannabinoid ligands on bone metabolism and argues in favour of the exploitation of cannabinoid receptors as targets for both anabolic and anti-resorptive therapy for treatment of complex multifaceted bone diseases such as osteoporosis. "
http://www.livestrong.com/article/108545-exercises-osteoporosis-using-hand-weights/
Vitamin D is needed in doses quite a bit higher than 1000-2000 IU daily. Doses of about 5000 IU daily are required for most people t get vitamin D levels above 50ng/ml, which is ideal.
Also, there is no mention of vitamin K2 or magnesium.
Vitamin K2 is highly effective for bone mineralization, and preventing calcification of soft tissues. Life Extension foundation (lef.org) had some interesting articles last year reviewing scientific studies of K2 and bone mineralization , and other benefits of K2.
Finally, the statement about red meat causing osteoporosis is a myth. This is only a concern if vitamin D and vitamin K2 levels are inadequate.
Osteoporosis is easily prevented in most people by taking:
vitamin D3 5000IU
Vitamin K2 (from natto) 200mcg daily
magnesium 400mg daily.
Calcium is not necessary and can even be harmful if one is deficient in D or K2.
So..yoga and bok choy? better than emboli or jaw pain!..thanks for the article...good to have options.
http://www.drugdanger.com/NEWS/20100914-ExpertsCallForChanges.htm and lots of others.
Also read about Calcitonin nasal spray, but really don't know much about it all. It's Rx drug made from salmon. Unlike bisphosphonates, it won’t make bones brittle.
Some key points to remember:
1. Take 500-1000 mg of magnesium a day and 500-800 mg of calcium – if you’re eating dairy every day, you may want to add more magnesium to your diet and supplements. But make sure to take the right kind of magnesium.
2. Strengthen your bones with bone-stressing exercise
3. Learn to balance. People break bones when they fall.
4. Reduce your stress. Stress hormones such as cortisol, pull calcium out of your bones.
A diet that's pH balanced - lots of greens and veggies - and less processed junk - helps also.
Milk is not good! Makes our bodies more acidic.
As for a beneficial diet for bone health, Susan Brown (Better Bones) has put out a ton of information on the benefits of eating an alkaline diet, including doing an excellent job of highlighting the latest studies...
http://www.betterbones.com/blog/post/More-support-for-the-link-between-vegetables-and-good-bone-health.aspx
http://www.nature.com/ejcn/journal/v65/n3/abs/ejcn2010264a.html?WT.ec_id=EJCN-201103
http://www.betterbones.com/alkalinebalance/default.aspx
She also has suggestions for exercise too, including yoga: http://www.betterbones.com/healthylifestyle/exercise-bonesandosteoporosis.aspx