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Lucy P. Marcus

Lucy P. Marcus

Posted: January 18, 2011 05:55 PM

A potentially unprecedented change in venture capital and in the funding of the science sector is on the cards as a consequence of today's economic climate and the austerity measures that are being introduced by many governments around the world, including the G7. Partly a consequence of the global financial crisis, this period of simultaneous change has additional consequences in the manner in which funding in the science sector and venture capital interact with, and affect, one another. These changes have created a perfect storm.

The science sector

The whole spectrum of sciences, including vitally important areas such as cleantech, life sciences and biotech, and engineering, is facing extreme upheaval, particularly related to the funding of scientific research. In an overall difficult economic situation, cuts by governments in the area of blue-skies research and less funding available from corporates have created an environment in which the funding of science that is not immediately of commercial value is seen as unnecessary, imprudent, and wasteful.

At the same time, scientific advancement has been very rapid, and tremendous progress has been made in all areas of science. But this has come at a price, quite literally: scientific research is expensive, it takes place at a very high level of complexity, and some of it is speculative with often long and rarely direct routes from idea to commercialization.

The venture capital funding environment

Venture capitalists in turn are also facing a difficult economic situation, albeit in a different way than scientists. Their responses have been externally constrained, but are also self-constraining. They are constrained by the limited partners who invest in venture capital funds and have an ever-decreasing appetite for risk. Yet, the funds themselves are also less likely to invest in early-stage scientific ventures, partly because of limited partner's reluctance to do so, but partly also because venture capitalists may not be fully ready and able to rise to the challenges of untangling the intricacy that investing in scientific ventures in their notional, blue-skies stage of development.

The complexity of ideas that underlies current scientific exploration has grown exponentially over the last few years. Informed and prudent investment decisions thus require a new level of sophisticated scientific expertise, and most venture funds are not well equipped to do this. As a consequence, they seek the comfort and greater certainty of later-stage investment that comes with a proven idea and income stream on its side.

The consequences of a troubled relationship

The pressure, from government, limited partners and venture funds, in the current economic climate to seek safe returns on any investment of public or private funds combined with the complexity of scientific developments and the expertise needed to judge their future commercial value has led to an ever-increasing gap in the market for the funding of complex blue-skies innovative thinking that solves problems for people and planet. Yet, it is this early stage blue-skies work that the rest of the chain for economic growth in the scientific sector is predicated upon. This raises three questions in relation to research that could have enormous positive impact: who funds it, who decides what gets funded, and what happens to things that are not funded?

To start with the last of these questions, the problem for many developed countries that were previously among the undisputed leaders in scientific research is this: there is an increasing amount of money available to fund blue-skies research among the so-called 'rising powers', especially in China and India. As it proves ever more difficult to raise funds, the possible consequences are an ideas and brain drain. At the moment this flight of early-stage ideas is offset by their return to countries such as the US and the UK at the point of testing because of the better protection of intellectual property rights here. But eventually and inevitably, China and India will address their shortcomings in this respect and then they will also retain the commercial benefits of the blue-skies research they are investing in. Moreover, and as seen in the case of Evergreen Solar moving its operations from the US to China, "the draw of Chinese state-owned banks and municipal governments... offering unbeatable assistance" is an indicator of an increasingly competitive market place where countries other than the G7 offer better conditions for funding long-term development and commercialization of new technology.

If retaining their positions as world leaders in scientific exploration and its commercialization is vital to the G7 economies, what needs to be done and are we willing to do it? The gap that needs to be covered is between the origin of an idea and that stage in its development where its successful commercialization is more likely than not. Early-stage investment funds can play a vital role in bridging this gap: they pick up where notional research leaves off but well before the commercial value of a discovery has been completely verified. Early-stage investment funds thus provide the answer to the question of who decides what gets funded because they bring together scientific experts with venture capitalists -- those who understand the complex science behind the idea right at the point of due diligence and those who have the business acumen to vet business plans, fund them, and guide their implementation.

Early-stage investment funds, however, do not in themselves answer the question of who invests in blue-skies research, but they can make it a more promising and less daunting venture by helping to contribute to a faster and more reliable idea-to-market process. In other words, they can contribute to creating an environment in which traditional investors in notional ideas, such as large corporates, governments and charitable trusts in partnership with universities and dedicated research centers, can be assured that proven ideas will be picked up by next-stage investors who invest in testing an idea and developing it for commercial exploitation. This is the role taken on by early-stage investors who, by taking a lasting and active interest in the success of the entrepreneurs they fund, also provide them with the credibility needed for later-stage investments by larger venture funds, thus performing the vital function of a feeder fund and contributing to the long-term success of their own initial investments and a justification for the investment of private and public funds at the first stage of blue-skies research.

Still, governments must not abdicate their responsibility and will need to decide if they are willing and able to step up and commit to creating an environment where blue-skies thinking is supported -- with direct investment and concrete incentives for the private sector to invest in notional work before its commercial value is fully tested. In other words, governments need to decide whether to make a strategic investment in blue-skies research and in their own futures as countries where science that is about people and planet can flourish.

Note: An edited version of this was published by The Times and on the Marcus Ventures website

 

Follow Lucy P. Marcus on Twitter: www.twitter.com/lucymarcus

A potentially unprecedented change in venture capital and in the funding of the science sector is on the cards as a consequence of today's economic climate and the austerity measures that are being in...
A potentially unprecedented change in venture capital and in the funding of the science sector is on the cards as a consequence of today's economic climate and the austerity measures that are being in...
 
 
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11:29 AM on 02/06/2011
Having spent much of my research career as a blue skies researcher, I have recently embarked on a number of translational projects, including a clinical trial and development of a therapeutic antibody. Getting funding for the latter work has not been difficult, but I have serious concerns as to whether or not our future blue skies research will continue to be supported. If it proves difficult I will see myself as having little choice other than going to colleagues in centres in China and setting up a dual site operation. The basic science would continue overseas, with of course all IP and commercialisation rights residing there, whilst the applied work would take place in the UK. Some American academics are already working in this way, which as you say, should prompt G7 governments into some serious thinking about funding blue skies science.
11:51 PM on 01/25/2011
I agree with the author that this is really a problem of the VCs making. 1) Despite all the talk of VCs being commercialization partners, I think in reality they are more like a bank. Banks do not invest in early technologies. The growing trend of angels is a result of this vacuum to invest at the true-seed stage. 2) One argument against this type of investing tend is risk, but I think it really the inability of the VCs (banks) to rachet down the diligence for a x00,000 investment vs. a x,000,000 investment. You will often hear that it takes as much time for a small investment as a large one. As they have designed their system, this is true, but only because they make it so.

Certainly it is easier to manage one investment than two smaller ones, but that does not necessarily mean you will get greater returns for your investor. Kauffman did a landmark study authored by Rob Wiltbank that shows that early stage returns are substantial. http://www.kauffman.org/newsroom/angel-groups-achieve-returns.aspx

-DMK
11:57 AM on 01/24/2011
Lucy, as you requested here is a link to my post on the challenges you outline in your post
http://smlxtralarge.com/2011/01/23/intractable-dilemmas-in-science-funding-and-venture-capital/

Kind regards
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Overtone
See bio on the Aesop Institute website
12:54 PM on 01/19/2011
Thank you for an excellent summary.

A lever that may change the picture is the little publicized threat of power grids collapsing due to solar flare emissions. These blackouts are projected by NASA and the NOAA to last for weeks and may include New York, Washington DC and many other cities.

A new eleven year sunspot cycle has begun and at least four such events are forecast during the next decade.

See Green Light at www.aesopinstitute.org for a few details and a strategy that can result in new approaches to funding potentially cost-competitive renewable energy breakthroughs that are in the birth canal.

Underwriting risk is what insurance is all about. That industry is severely impacted by climate change and can develop new products that minimize venture risk in their own self-interest.

Grid collapse has huge loss implications for the financial industry. If the grid goes down for weeks the cost is estimated by NASA to range between 1-2 Trillion Dollars the first year. This is similar to the cost of both the recent wars combined.

Adventure capital is always rare. But, it may now be necessary to insure a livable planet.

We are at roughly 390 ppm of Carbon in the atmosphere and gaining 2ppm annually. A recent study suggests 400 ppm may be the tipping point in the arctic.

That suggests an emergency effort is needed and adequate liquidity is the lacking key to the problem.

Ingenuity and capital is needed as never before!
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Vincent Gormley
Artist, activist, volunteer, compassion lives
01:47 PM on 01/19/2011
faved again, Great website by the way!
09:32 AM on 01/19/2011
This article is absolutely correct. I have been very fortunate to maintain my research funding, but many of my colleagues are not so lucky. We have some of the most brilliant scientists on the planet, but they are quickly headed overseas or simply quitting. My recent (and first) visit to China was an eye-opener. At a time when I am struggling to keep my small lab and staff of 4 operating, they had enormous facilities filled with millions of dollars worth of the latest equipment and virtually unlimited funding for things like vaccine and drug development. I was also shocked to see that there were many labs run by U.S. scientists that fly over and do their work in China. We train the peoples of other countries, in their own countries, and get nothing from it but publications.

I have also watched some excellent research on promising new drugs and vaccines cease to exist because there is not enough funding. Look at the ARRA funding that was so highly touted. There were 20,000 applications for $200 million! About 1% got funding for 2 years only. That is simply pathetic, and it is becoming even worse.

I was recently talking to another Prof., and he asked if I would like to see my children do what we do. I was surprised when I blurted out NO WAY!

Check the numbers for yourself:
http://www.the-rheumatologist.org/details/article/871179/Stimulus_Package_Creates_Flurry_of_Research_Funds.html
09:05 PM on 01/18/2011
There has been a growing gap between basic research and research and development. Nano-scale science and genomics are accelerating breakthroughs; almost daily in almost every field. The universities are under pressure to develop enterprises to create new revenues to support research in an environment of shrinking government grants. One major impediment is a confounding lack of people with the combination of skills in science, business, and law to help migrate these new discoveries from the laboratory to business enterprise. Some universities are developing a discipline called "technology transfer and commercialization." However, the universities are confronting budget cuts and are having great difficulties just keeping the lights on.

This should be a time of prosperity if the universities were not crippled by a confounding lack of funds.
08:30 PM on 01/18/2011
USA Bankers who own the Federal Reserve are interested in owning the whole world, and they will pay the price for it. A Third Revolution will come soon or later.

The Bankers could still be rich and continue to own the USA, in financing manufacturing production in the USA. If they did 20 years ago, I could be buying a new car for $1000 and in that process the dollar could be stronger than it is today. But what the Bankers chose was to invest in China including India, so that their companies in China can hopelly control China's economy and thus the whole world and its mineral resources. So, what went wrong was that the Chinese were very patriots and enacted laws that put to death or life in prison, anyone involved even in small corruption. And the interest money China gets from these usa companies were put to use to finance the USA gov's useless wars and create more chinese manufacturing companies that are feeding the whole world and in return, to get a chunk of resource minerals back.

In brief, the Bankers cared less of USA Middle Class, they prefered more the money economy than production economy, as it was easier to rule the world without a strong usa middle class.
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Kringle
Resurrection of the Gifting Spirit
08:17 PM on 01/18/2011
Remember "buyer's remorse" during the computer boom?

I would suggest since we've innovated our information systems and communications technologies first, we're facing a renaissance of innovations in nearly EVERY other field. If this is correct, I imagine it may be very difficult for VCs to pick the "Next Big Thing".
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RMankovitz
Researcher, inventor, entrepreneur, author
07:05 PM on 01/18/2011
As an inventor, disruptive technologist, entrepreneur, and intellectual property attorney, I can certainly relate to this article. As a result of what I perceive as the shortsightedness of the venture market, I have developed my own strategy for moving forward the idea-to-market process. As of late, my focus has been on nature-based primary illness prevention, where new strategies can provide enormous benefit to the health of the population.

My business strategy looks something like this. Since I have no shortage of ideas (65+ patents), I choose those which are likely to yield the most bang for the buck in terms of benefit to the user, and commercial success. When appropriate, I privately fund university research to confirm the hypothesis, and file patent applications covering all facets of the invention. I then offer the technology for license/acquisition to established players in the field, and Joint Ventures may be formed. Royalties received from such activities are plowed back into research for the next project. Venture capital? During the time it takes them to do their diligence, I can usually take the project to market, and establish a risk profile that suits my taste.

Roy Mankovitz
http://www.PatentLab.com
http://www.Berrynol.com
http://www.Officizer.com
http://www.MontecitoWellness.com
http://www.engineering.columbia.edu/roy-mankovitz-rocket-scientist-and-health-strategist
http://en.wikipedia.org/wiki/Roy_Mankovitz
10:25 PM on 01/18/2011
I wish there were more responsible entrepeneurs like yourself! I'll be in contact, as I have some ideas and interest in such ventures as well; thanks from one idealistic American to another