Here's the thing: "2048" isn't just a clone. It's a clone of another clone, "1024," which has gone relatively unnoticed in all of this. That's three games, without counting the clones that "2048" has inevitably spawned.
Suppose someone made a variation of 2048 on the world's most powerful CEOs. If the lower-valued numbers were largely women CEOs, it could potentially affect how players saw women in leadership positions. Same effect with college academic or sports rankings.