Alfonso's harsh family and personal and professional circumstances were very similar to those of that woman in space. Physical and metaphysical garbage, waste from fear, greed, ignorance -- and many of those elements of the sublime and putrid within the film industry lined up like missiles that hit his ship.
In my mind, the film is about transcending gravity; the quest to live life a few feet off the ground. The Kaballah teaches that growth and impact emerge from living outside our comfort zone. The ground offers security but the most memorable moments in life and fulfillment arise when we strive to live a little higher and brighter.