The historian of mathematics E. T. Bell once wrote, "Archimedes, Newton, and Gauss; these three are in a class by themselves among the great mathematicians, and it is not for ordinary mortals to attempt to rank them in order of merit."
Research into treatment-resistant depression is particularly hampered by the "silo" effect -- a myriad of individual projects with very specific parameters. In 2010 a woman named Audrey Gruss decided to do something about this seemingly intractable dysfunction.
The time is excruciatingly right, the hell of the current system screams at us in daily headlines, most people want it -- but war is the way things are. Government serves it. The economy serves it. The media serve it.
Asking the brain to understand where reality comes from is like asking a robot to dismantle itself to find out what it's made of -- you won't have a machine after the dismantling is done, and therefore no answer.