Whether all these figures are anti-heroes, or in some cases something else entirely, is an interesting question. As is the question of why anti-heroes are so important in quality television. Short form answer is that they match the times. It's a mostly cynical and sour era, with little faith in institutions or, generally speaking, leaders.
To get to the bottom of Louis-Dreyfus' appeal, one has to examine the facts: She's irrefutably beautiful, but is no girlie-girl and prefers the company of men who better appreciate her bawdy, take-no-prisoners outlook on life. Though she was born in New York City, the actress taps into an easy accessibility that makes her a relatable "everywoman."