Whether the glitch is in the value or the glitch is in the goal, we have several techniques in NLP to reconcile the two. When your values and goals are in alignment, you'll no longer feel frustrated as you pursue what you desire.
People and situations show up in our lives so we can learn and grow. Though I wouldn't encourage you to seek out pain, it's not something to avoid either. It's just part of life -- and it can be a gift.
Run this exercise through all the areas of your life: career, health and fitness, relationships, spirituality, family, and personal growth. As you do so, you'll start to find a pattern or theme that will lead you to a sense of your overall purpose.