Yes, living your all comes with sacrifice. But by getting rid of the things and relationships that make you only somewhat happy (or plain unhappy), you get to live a life filled with what you love best, and then focus on them with everything you've got.
If we really want to be intentional in our lives, if we really want to stick to decisions about our success and happiness, then we must be OK with not being a part of everything... of anything other than what's going on for us right now.
Even when we have what we want, we still can't land in this moment. We cling to the illusion that there are indeed a set of circumstances that, once we achieve them, will finally, miraculously make this moment inhabitable.
Making the most of each moment requires that we show up for it as our fully awakened, aware selves. It requires that we not be attached to how the moment unfolds or the outcome, but be a willing participant in the here and now, meeting the moment as it is.