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Take 2: Why Genetic Recombination Is Not Random, and How Cells Take Advantage of Non-randomness

James A. Shapiro | Posted 10.07.2012 | Science
James A. Shapiro

In the pre-DNA era, students were all taught that genetic change is random and accidental. Because the molecular details were inaccessible, this was the default assumption. But once we learned about DNA carrying hereditary information, we could research the details of how changes occur.

Legitimate and Illegitimate Recombination: Targeting Homologous Exchange for Multiple Adaptive Purposes

James A. Shapiro | Posted 10.02.2012 | Science
James A. Shapiro

The molecular studies are remarkable in uncovering a striking variety of ways cells have adapted homologous recombination for diverse purposes.