Libertarianism and transhumanism have too many deep philosophical principles in common to not grow and evolve together. The all-important role of personal freedom makes the two ideologies a natural fit for one another.
Government is a science. Political science is, according to Aristotle, the study of the state. But if governance is a science why don't we see more experimenting with the state? Why aren't we trying new things in government?
Innovation and progress requires experimentation -- trial and error. Unfortunately, for entrepreneurs with ideas for "startup countries," there's no way for them to experiment. It's not like the software industry where all you need is a laptop.