The calls for Todd Akin's resignation likely had nothing to do with the substance of his remarks. Akin's mistake was that opening his mouth with crazy talk made it much harder for Republicans to win a sure Senate seat pickup with him on the ballot.
What Todd Akin said and believes doesn't just play into a media-catchy, election year "war on women" narrative. It's part of a reactionary, fundamentalist backlash to modernity. It's a war on science. It's a war on facts. It's a war on critical thinking.