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Randi Hutter Epstein, MD, MPH

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The Fertility Paradox

Posted: 06/14/2012 12:27 pm

When Dr. Pasquale Patrizio, the director of the Yale Fertility Center and professor of obstetrics and gynecology, told me about his latest project, I thought I must have heard him wrong. He and a cohort of fertility experts aim to create low-cost fertility clinics for poor couples in poor countries. I mean, isn't the problem there just the opposite? Staunching a population explosion?

Well yes and no.

The World Health Organization predicts that by 2050, the developing world will add 35 million people annually. Yet, at the same time in those same overpopulated regions, about one in three couples are infertile. It doesn't take a math genius to figure out that some people are having litters of kids and others none at all. Public health officials call it the Fertility Paradox.

Ideally, what's needed, they say, are reproductive health centers that offer three things: quality prenatal and birthing care; contraceptives to women having too many babies, and fertility treatment to those who can't have any. But there's the rub. Ideally. The obstacle -- and it's a huge one -- is turning their vision into a reality. And yet, the notion seems to have been gaining momentum in the last few years.

"The irony," Dr. Willem Ombelet, a professor of obstetrics and gynecology at the Institute for Fertility Technology in Genk, Belgium, told me "is that being childless in developing countries is much more difficult than being childless is the developed world and yet that's where the efforts are being made." (The non-ironic part is that fertility treatment is a huge money-maker in developed countries.)

All too often, women from poor villages who cannot have babies are cast aside from their marriages and are deemed unemployable -- sometimes they resort to prostitution. Marcia Inhorn, a Yale professor of anthropology, has seen firsthand the impact of infertility on women in developed countries, documenting how they will spend limited resources on quack, dangerous remedies. What's more, say some public health officials, infertility is a disease and just like anyone with a treatable ailment, they deserve the right to therapy too. Ombelet created a not-for-profit called The Walking Egg. Patrizio hopes that Yale will take the lead and is working with colleagues in other institutions on a not-for-profit called Friends of Low Cost Fertility.

And while cheap IVF sounds like an oxymoron, a few teams say they are beginning to test techniques. Here are their ideas, in a nutshell:

  1. Fewer diagnostic tests. You just need to know just enough to guide the course of treatment.
  2. Cheaper drugs. Clomiphone citrate pills rev up the ovaries but not as much as the potent hormone shots -- and at a fraction of the price.
  3. Modified Lab rather than a multi-million dollar set-up.

Number three is the trickiest of all. University of Colorado's Dr. Jonathan Van Blerkom, a pioneering embryologist and laboratory director at Colorado Reproductive Endocrinology at the Rose Medical Center in Denver, is working with Ombelet on a portable lab, that includes a shoebox-size incubator and small test tubes for the embryos.

But not everyone is as gung-ho. Dr. Wendy Chavkin, a Columbia University professor of population and family health, the author of Global Motherhood and former director of the Soros Reproductive Health and Human Rights Fellowship, said it's back to public health 101. "From a public health vantage point, there are certain principles about how to allocate resources and address population level health problems -- and it does not only reflect what people want," said Chavkin. "It's about the severity of the problem, numbers affected, the underlying causes, and the ability to effectively intervene. There are human rights evidence based approaches for how to construct or redesign a health care package. In my book, the currently available fertility treatments would rank pretty low, especially in low resource settings where curable infectious diseases and their consequences, including cancers, too often go untreated." Chavkin was also a director of the Soros Reproductive Health and Human Rights Fellowship.

Fertility doctors are known for testing the boundaries, but their latest pursuit, is really testing the limits of public health, human rights, and health economics. And while, their dream seems unattainable, let's hope they can prove the naysayers wrong.

 

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When Dr. Pasquale Patrizio, the director of the Yale Fertility Center and professor of obstetrics and gynecology, told me about his latest project, I thought I must have heard him wrong. He and a coho...
When Dr. Pasquale Patrizio, the director of the Yale Fertility Center and professor of obstetrics and gynecology, told me about his latest project, I thought I must have heard him wrong. He and a coho...
 
 
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iflew
Pro Publiae Bonae
04:17 PM on 06/21/2012
Another case of "those who can do".
03:00 PM on 06/20/2012
Very interesting article and paradox. Infertility is tragic for all those who long for a baby and can't have one One's SES should make no difference. Sadly, many people are more concerned about forcing women to have children who don't want to have them than helping those who desperately want them.

Interestingly, the rights to one of my books, "The Unofficial Guide to Getting Pregnant," was bought a publishing house in China! That was the last place I thought people would want to read my book. But, as you point out, there are many social pressure on women to have children, and in China, it's male children. Maybe they thought I gave advice on sex selection (I barely touched on the subject.)
09:59 PM on 06/17/2012
I have a question not being asked here. If less potent drugs are available, namely "Clomiphone citrate pills rev up the ovaries but not as much as the potent hormone shots", then why aren't THESE being used instead of turning women into Octomoms?
11:01 PM on 06/17/2012
good thinking: I think there may be a trend to start using minimal hormone stimulation and reduce the numbers of multiples: healthier and cheaper.
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dsws
No owning ideas. Limit only commercial use.
01:30 AM on 06/17/2012
There are no overpopulated areas. The population of the world is the population of the world, and the resources of the world are the resources of the world. If at some point the former is more than the latter can support, that's a fact about the world, not about a particular area.

Some areas consume vastly more of the resources than others. But if anything that should mean these areas count more toward whether the world is overpopulated, not less.
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CountLeo
It's a rich language - learn to use it.
12:48 PM on 06/16/2012
The idea of infertility or sub-fertility as a disease giving one the right to health care is interesting. I am surprised, though, at the stat that one-in-three couples in these areas are infertile. Would like to see the documentation.
11:08 PM on 06/17/2012
most of the infertility is caused by sexually transmitted diseases. this article, http://www.path.org/publications/files/eol15_3.pdf, sites stats upwards to 14 to 27 percent. Others by Marcia Inhorn, in Human Reproduction estimate upwards of 30 percent. while i'm sure the precise numbers vary--and statistics are rough--infertility is usually secondary to infections, not due to delayed childbirth and reasons we see here in the U.S.
02:03 AM on 06/18/2012
Then maybe that's the problem they may want to attack first?

Oh... and creating good living conditions for the children they make... like sanitation, clean water, safe, nutritious food, shelter, heat, transportation, communication, education...

But I guess that's secondary to bringing more children to the world?
ThinkCreeps
Seriously, it's time.
07:31 AM on 06/18/2012
So, are some cheap ovary-stimulating drugs ever going to overcome STD-caused infertility?
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Just4theHalibut
04:41 PM on 06/15/2012
Too often purveyors of contraceptives in third world countries are shunned as " baby-killers" or even called genocidal. If the same clinic was providing contraception to fertile women who wanted it, AND fertility treatments to barren women, that would go a long way in undermining these misconceptions. However, I can see a moral dilemma here... what if a woman already had 5 kids but had developed an infertility problem and wanted 6 kids like all her friends?
iflew
Pro Publiae Bonae
04:32 PM on 06/21/2012
Regarding those without children. Are they failing to 'keep their end up'? Is that sinful? Are nuns and priests sinful for not having children or for having children? So far food production has kept up with population growth, at least in the lands of plenty located around the world. Hive stress is a problem waiting to work through the food supply. Bees have to make certain crops. Without bees food sources can experience decline. Climate change allowed Oklahoma some unusually wet weather and good crops, but when rainfall normalized a dust bowl was created. The old solution to food shortage has been for those able to move to better food sources or canibalism. Two ways to know: 1. Wait, 2. Time travel.
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phal4875
The world is run by cats; we just feed them.
02:51 PM on 06/15/2012
The issue mentioned by Dr. Epstein is surprising to this reader. When one thinks of overpopulation, one tends not to think of concurrent fertility problems.
06:33 PM on 06/17/2012
Hence the title of the article.