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Sweet on Sweets: Scientists Investigate Addictive Properties of Sugar

Posted: 09/06/2012 9:30 am

By Hannah Gibson

Hannah is a teen media team member of Science Club for Girls and a high school student in Cambridge, MA.

Sugary foods and beverages are frequently marketed as if they have addictive qualities, especially in advertising geared toward children. Many of us remember the "Cocoa Puffs" commercials, in which Sonny the Cuckoo bird tries all sorts of crazy schemes to stop eating Cocoa Puffs. He inevitably gets jittery, sees Cocoa Puffs everywhere, and starts screaming "Cuckoo for Cocoa Puffs, Cuckoo for Cocoa Puffs!" Advertisements often feature phrases like "Too good to resist." An Australian cereal made of chocolate filled squares even has the name "Krave."

The average American child consumes one or more soda or soft drinks per day, which provides 10 percent of their daily calorie intake. In an interview this year with Radio Boston, Kelly Brownell, Director of Yale's Rudd Center for Food Policy and Obesity, stated that sugary soft drinks are especially damaging to health because our bodies do not recognize them as food. Instead, the sugar in the drink acts like a drug and triggers an addictive process.

It's hard to say whether sugar actually is an addictive substance, since it is unclear what an addiction actually is. Webster's New World Dictionary defines chemical addiction, or dependence, as a "compulsive physiological and psychological need for a habit-forming substance." Certain physical and psychological signs separate true chemical dependence from habitual enjoyment of a substance or activity. According to the American Psychiatric Organization, addiction is characterized by three behaviors: binging (consuming large amounts of food in a small amount of time after a period of abstinence), withdrawal (depression and anxiety if the substance is not available) and cravings. The cravings increase the longer the substance is not available.

Rochelle Schwarts-Bloom, a professor at the Duke University Medical center, explains that addictive drugs affect the brain by triggering the release of chemical neurotransmitters, which create a "high."

There is evidence that sugar has addictive properties. A team of Princeton University psychologists, lead by Dr. Bart Hoebel, produced in rats the behaviors and brain chemistry of addiction. The rats were divided into four groups. The experimental group was given access to feed and sugar for 12 hours then deprived of both for 12 hours. Hoebel also set up three control groups. One group had access to sugar and feed at all times, one had access to only feed at all times, and one had access to only feed in 12-hour periods. The rats in the control groups displayed no signs of addiction, but the group on the 12-hour on, 12-hour off sugar and feed schedule did. Rats in the experimental group that were later denied sugar for 24 hours tended to binge, exhibit withdrawal symptoms -- like tremors and anxiety -- and display behaviors consistent with craving; this response was similar to rats on morphine or cocaine. Hoebel and his team also found that sugar consumption triggered the release of the neurotransmitter, dopamine, in the rat's brains. Addictive drugs like morphine and cocaine trigger a similar response, suggesting an addictive quality to sugar.

Other researchers, like University of Swansea neuroscientist David Benton, have criticized Hoebel's work, pointing out that a huge variety of actions and substances trigger a release of dopamine in the brain. Sure, sugar and cocaine stimulate release of neurotransmitters, but so do music, humor, winning a prize, familiar faces, attractive faces, smiling faces, and being in love. Clearly, the release of dopamine isn't sufficient evidence of addiction! Further, rats on the alternating sugar and feed schedule showed the neurological and behavioral signs of addiction, but the rats with constant access to sugar did not. This suggests that perhaps sugar is not an addictive substance, like heroin or cocaine, but that addiction to sugar may occur if it's eaten in a period of binging followed by long periods of restraint.

Even if Americans are not clinically "addicted" to sugar, they are definitely eating way too much of it. The average American eats 64 pounds of sugar a year; that's about 124 grams (31 teaspoons) of sugar per day, which is more than three times the recommended amount. The American Heart Association recommends that a person following a 2,000-calorie a day diet consume 36 grams (nine teaspoons) of sugar daily. There are many health conditions linked to a diet too high in sugar, including an increased risk for heart disease, kidney disease, liver disease, diabetes, gout, hypertension, gum disease, tooth decay, obesity, and the substance potentially has addictive properties.

There has been a push in recent years to limit the amount of sugar in packaged food. Many parents are concerned about the aggressive marketing of sugary, unhealthy foods and beverages to children and are trying to limit their sale in school cafeterias. Robert Lustig, Laura A. Schmidt and Claire D. Brindis, in their February article "The toxic truth about sugar," advocate for regulations and a tax on sugary products. In May, Mayor of New York City Michael Bloomberg proposed a ban on oversized sugary beverages. Recently in Massachusetts, a legislative attempt to end the sales tax exemption for soda failed; the exemption makes it easier to for sodas to be cheaper. In some places, soda can be cheaper than water.

According to Ashley Gearhardt, a researcher at Yale University, sugar is minimally regulated, and food companies receive subsidies form the federal government, making it possible for them to produce extremely sugary foods. Gearhardt is concerned about the rapid increase in the amount of sugar in the American diet and feels that "although much research needs to be done, the evidence that sugar can trigger an addictive process is impressive and convincing, is definitely a public health issue." While it is still unclear if sugar is addictive, there is enough evidence to suggest that foods too high in sugar do present public health risks. Shedding light on the dangerous aspects of sugar through research and education will help address the issue of sugar as a national health risk.

Check out our stop motion video, "The Sour on Sugar," below.


Check out more from the Science Club for Girls' MadSciMag here.

 
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HUFFPOST BLOGGER
Rebecca Searles
Social Community Editor, Science/Green/Tech
07:06 PM on 10/01/2012
Love this, Hannah!
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TakeSake
The United States for All Americans
01:15 PM on 09/11/2012
My sugar substitute: vinegar.
11:09 PM on 09/10/2012
"There has been a push in recent years to limit the amount of sugar in packaged food."

...yeah right.
02:29 AM on 09/09/2012
Problem with Jonathan Robinson's quote of David Benton's work you linked to is Hoebel's research never tried to "prove" anything. This is a fundamental misunderstanding of the scientific method and one that I routinely see among people who should know better. Hoebel and Avena--who is a heroine of mine--did research in rats to test a "proof of concept" to see if rats fed ad-libitum sugar could develop a measurable addiction to use as a loose analog for human addiction. While the dopamine levels were considered, they also tested acetylcholine response curves as a function of time and compared these to heroin response curves. They also tested behavioral responses and used a CONTROL group for comparison. The fact all these factors showed patterns analogous to heroin addiction (albeit, at a lower level) suggests the rat model of addiction is at least viable.

read that last sentence again, or better yet, read the original paper instead of relying on those other folks: http://bit.ly/NiA9Pv

The studies have their limits: sugar alone is not addictive, rather, it is when mixed with other high-calorie foods (fats, breads, pastas) that the pattern becomes more evident. Long story short, most research shows that the model of sugar as "addictive" is CONSISTENT with other known addictive substances like heroin. Benton, by comparing just dopamine and ignoring the other factors is disingenuously re-framing the study into a straw-man he can knock down... not cool
HUFFPOST SUPER USER
Jeremy Bursac
You're not the bossa nova me.
03:07 AM on 09/10/2012
Much of your post is beyond my ability to follow, but I consider in layman's terms a key component of addiction to be a need for more and more and more to achieve the same chemical payoff. And that addiction is progressive in nature - that if you abstain for a period of time, the addiction will not recede, but can actually continue to progress during that time of abstention in such a way that if you start back up you will almost immediately be progressed to the same point you would be at had you not abstained.

By these two criteria I am not addicted to Ben and Jerry's. I merely eat a lot, too much, of it. So I like my criteria.
10:04 PM on 09/10/2012
i was trying to show how Hoebel's research has been misinterpreted by some people. He proposed that an animal model could serve as an analog for human addiction. Animal models are always tricky, so he peppered his paper with lots of caveats, but the usefulness of an animal model should be obvious: it's better to play with rats than humans.

The problem with applying personal experience--like your love of benny jerrys-- is that it suffers from bias. this is why unbiased testing it at a biochemical level is better. are there problems with the model, of course! addiction is complicated and tricky, but that's no reason to dismiss research that could go a long way to helping some sufferers with this problem
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03:48 PM on 09/07/2012
heroin C21H23NO5
table sugar C12H22O11

we should be looking more closely at chemical bonding of foods.
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HUFFPOST SUPER USER
tomteboda
07:37 PM on 09/09/2012
Quick!!! I see a pattern! carbon, and hydrogen atoms are present in BOTH!!!! We better ban them.
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jf12
When I saw her I marveled greatly.
06:42 PM on 09/06/2012
Not all sugar is equally bad.
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gratnam
Expand your mind until it hurts
08:56 PM on 09/15/2012
Really. Any further info?
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jf12
When I saw her I marveled greatly.
08:22 AM on 09/16/2012
Inositol, for example.
05:38 PM on 09/06/2012
Interesting
09:54 AM on 09/06/2012
As an adult I have come to see sugar as poison: my body can no longer burn it off.