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Simon LeVay

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The Paradox of Gay Genes

Posted: 10/01/2012 1:18 pm

In 1991, when I was a neuroscientist at the Salk Institute in San Diego, I published a study describing a difference in brain structure between gay and straight men. Since that time I've given many public lectures on the biology of sexual orientation. One of the commonest questions I get is this: If being gay is genetic, and gay sex doesn't produce children, why don't those genes die out?

That's a sensible question, and one to which we don't yet have a crystal-clear answer. I'll suggest some possible answers in a moment. First, though, I should emphasize that not everything in biology is genetic. In the case of homosexuality, most estimates (derived from twin studies) are that genes account for no more than about half of the total causation of this trait. The remaining causes include hormonal factors operating during fetal life -- factors that may not be under genetic control.

Another point is that, while gay sex doesn't produce children, gay people often do so. No one could be gayer than Oscar Wilde, for example, yet he fathered two children. Lesbians are even more likely than gay men to be parents. But both lesbians and gay men do have fewer children, on average, than their heterosexual peers, so 'gay genes' should indeed fare poorly over the long term.

The key to understanding how gay genes survive is the realization that such genes exist, not only in gay people themselves, but also in some of their non-gay relatives. For example, the sisters of a gay man might have inherited the same gene that he did, but because different genes are thought to promote homosexuality in men and in women, this 'gay male gene' won't make them lesbian. If the gay man helps his sisters raise more children than they would otherwise be capable of, then the decreased reproductive success of the gay man might be more than compensated by an increased reproductive success of his sisters, and it would be they, not he, who pass the gene on to the next generation. This is the so-called 'kin selection' hypothesis.

Do gay men in fact help their sisters raise enough extra children to compensate for their own lower fecundity? Although gay men are generally well-disposed towards their sisters, nephews, and nieces, most studies fail to find that they offer enough support -- financial or otherwise--to significantly increase their sisters' reproductive success. (An exception is offered by anthropologists Paul Vasey and Doug VanderLaan of Lethbridge University: they report that feminine gay men in American Samoa -- men who are locally referred to as fa'afafine -- do provide substantial child-rearing assistance to their sisters.)

Another possibility is that these sisters (and other female relatives) of gay men might have extra children, not on account of any assistance offered by the gay men, but by the direct action of 'gay male genes' within themselves. After all, if we think of gay male genes as genes that increase sexual attraction to males, then these genes might actually benefit the reproductive success of heterosexual women who possess them -- by making them even more sexually attracted to males than they otherwise would have been, and therefore more sexually active. Conversely, 'lesbian genes' might increase the reproductive success of heterosexual men by the same mechanism.

Some support for this hypothesis comes from studies conducted in Italy and in Britain, which have found that women with gay male relatives -- and who might therefore carry a gay male gene, do have significantly more children than women with no such relatives. This effect was seen even for women whose gay male relatives cropped up in a later generation, so that the men were not in a position to provide any material assistance to those women when they were having children. Still, there are also studies that fail to find this effect, so it's not yet clear whether it could be a general mechanism for the persistence of gay genes.

Yet another idea is that it's the same-sex relatives of gay men who enjoy a reproductive advantage. How would that work? According to economist Ed Miller of the University of New Orleans, several genes are floating around in the gene pool that make men more feminine in a variety of respects. Men who happen to inherit one or two of these genes are still heterosexual, Miller suggests, but their mild femininity -- which shows itself in the form of decreased aggressiveness, greater empathy, and the like -- makes them more attractive to women, and thus able to have more children, as compared with straight men who lack such genes. When more than two or three such genes happen to end up in the same man, the process of feminization increases to the point that it includes sexual attraction to males -- that is, it makes their owner gay. Such a model is certainly consistent with the observation that gay men are, on average, considerably more feminine that straight men in a variety of psychological traits.

According to a research group led by Brendan Zietsch of the Queensland Institute of Medical Research, feminine straight men do have more female sex partners than more masculine men do. Thus the positive effect of feminizing genes on the reproductive success of straight men could outweigh their negative effect on gay men. Similarly, Zietsch's group found that masculinity in straight women is associated with a larger number of male sex partners, suggesting that Miller's hypothesis could explain the persistence of lesbian genes too.

As a happy homosexual, I find it a bit disconcerting that my sexual orientation might simply be the price that evolution pays to improve straight men's performance in the sexual marketplace. Whether any of these explanations for the persistence of gay genes is correct, however, is a matter of speculation -- and it will likely remain so until these genes have been identified and their mechanism of action understood.

Simon LeVay, Ph.D., is the author of
Gay, Straight, and the Reason Why: The Science of Sexual Orientation (Oxford University Press, 2011).

 
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12:22 AM on 10/08/2012
Your sexual orientation is a gene formed when you're in the final stages of the developmental stages in the fetus. There are exceptions. There are some guys that are attracted to other guys later in life due to the lack of any father figure presence. As far as feminine or masculine - that is a generalization. It's split down the middle there are feminine straight guys and masculine gay guys. You can't stereotype based on the media's choices of how they promote what and who a gay guy is.
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Novgorod Viking
Metropolitan of All Russia NOVGOROD
09:37 AM on 10/06/2012
Ummm.....

Excuse me, Doctor....

But....

Parents are Heterosexual, no matter what they do before or after conception.
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HotelDrama
02:27 PM on 10/06/2012
Many parents are homosexual.
03:58 AM on 10/07/2012
what does that even mean? It makes absolutely no sense. Gay, straight, lesbian, bisexual people can all have biological children, even asexual virgins can have children.
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Warren Hart
03:21 PM on 10/05/2012
I'm gay, not that that makes me any particular authority, but I know a little bit about it. I don't think my genes caused me to like other guys. I accept that the brains of Homosexual and heterosexual people are different, but the cause doesn't have to be genetic or due to some hormonal exposure during the fetal stage. I mean, the brain changes in response to external stimuli as well. I just think that most gay people are gay because of the relationship circumstances they were in at a very early age, when the brain is more open, and then the persons brain develops according to those early circumstances. It is still unchangeable though. That's just my opinion based on knowing myself and talking to 100's of other gay people over my lifetime.
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HotelDrama
05:31 PM on 10/05/2012
So why type of "relationship circumstances" would make one gay? Does this same "circumstance" also make people heterosexual? If the brain is changeable at an early age, when and why does it become unchangeable?
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spanprof11
cogito ergo sum
10:20 PM on 10/06/2012
Sexual orientation forms early on in the configuration of the amygdala. It is as unchangeable as a congenital withered arm.
11:51 PM on 10/04/2012
Why is he supporting the stereotype that gay men are feminine? He has no proof to back up that "gay male" genes cause femininity. This is the biggest offense of this article.
Being a gay male is the ultimate expression of masculinity.
Also the whole idea that sisters of gay men would look to their gay brothers for child-rearing is also unfounded. Yes, "gay" genes can and will be passed down to generations. Throughout history gays have been forced to live in the closet so, yes, they had children and passed on their genes too. My mother's brother was gay. My mother and her sister both had large families and each had a gay son. Their brother did not assist them in any way. I am gay but none of my siblings have large families (out of 7 siblings there are only 8 children...so increase in reproductivity by my four sisters). This whole concept of larger families of siblings of gays is erroneous. Family size has nothing to do with this factor...many are at play. My mother and aunt came from solid, middle class families which could afford to have larger families. (Moreover, all but one of my aunts and uncles had less than 5 children each. So where does this leave my paternal aunts?)
TomMartin
Freedom and equality.
10:12 AM on 10/05/2012
He is not saying all gay men are effeminate, just that many are, compared to fewer of the straight men.
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OhDidItGetInYourEye
That mistletoe in my back pocket is for you.
12:30 PM on 10/07/2012
Now that metrosexual is a thing, that stat just doesn't sit with truth anymore. I know many girly guys and they're not all gay. If you need proof of this, just look at the male youth these days...they're far from heading toward masculine.

Think of all those guys who wear "skinny pants". Totally feminine.
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HotelDrama
12:21 PM on 10/05/2012
There have been studies that have shown that the more pregnancies a women has, the higher chances of having a homosexual son. And remember, family size now is greatly impacted by culture.
And notice how the author uses the word 'hypotheses?'
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Carl E Cook
10:07 PM on 10/04/2012
there is no gay gene.......is there a polygamy gene?...........an auto-eroticism gene?......etc.?
if there is a gay gene, then there must be a hetero gene, too? what about a necrophilia gene..........???
ABSURD!
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10:12 AM on 10/05/2012
The polygamy gene is rather obvious, like, it’s also the one that causes infidelity. Polygamy was introduced in several cultures as a response. The Roman marital system, we now view as the norm, was not the most common throughout history, even the bible attests to that.
As for necrophilia, they’re easy and often the desire of ‘what’s inside to come out’ over-rides sense and escapes in unusual paraphilic ways.
These things are not as wildly unreasonable as one would first hope them to be, however that’s not a command to engage all of them, choice is still with the person.
TomMartin
Freedom and equality.
10:23 AM on 10/05/2012
Yes, there is a polygamy gene or genes, which is why more men than women engage in sex with several partners, so at least some of such genes are on sex chromosomes. I assume all people with sexual feelings are also auto-erotic, whether they choose to masturbate or restrain themselves for some religious reason. But a few people are totally asexual, no sexual feelings even when they would try to masturbate, that is surely governed by genes too. I don't know about necrophilia genes, it could be due to an infection. So far I have not heard of necrophilia in animals, though I would not exclude the possibility. But monogamy, polygamy, autoeroticism, homosexuality and of course heterosexuality are very common among animals, so there are genes for all of these.
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FlipFlopMitt
Hates Republicans and blue dog Democrats.
09:54 PM on 10/04/2012
I had gay jeans. They had studs around the pockets and were too tight so I took them back.
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09:30 PM on 10/04/2012
Simon: What if there was an intermediate condition that conferred a survival advantage? Imagine, if prior to modern societal conventions, humans lived in a polygamous groups where an alpha male (hereterosexual) could dominate and secure the majority of matings with a group of females. If that individual was challenged by a bisexual male that had an exclusively homosexual ally, the alliance could work together to depose the single heterosexual alpha. The intermediate condition could therefore confer a genetic advantage. While maladaptive for the exclusively homosexual individual, gay genes partially expressed in the bisexual male could persist in a population, and so would the exclusively homosexual individuals. I don't have any evidence to support this model, but if you watch the Disney movie Chimpanzee closely, you will see that the alpha male does have sexual relations with other males after the battle with the invading band. If such a model were to be true, societies that supress homosexuality and force the homosexual condition to reproduce, would actually INCREASE the frequency of homosexual genes in the population above 'natural' background rates. Perhaps that's why so many mormons are gay?
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Marcusarilius
Marooned Star Traveler
08:39 PM on 10/04/2012
Are the Gay Genes tighter than Straight Genes?
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10:06 AM on 10/05/2012
yes, the saudi arabian religious police use this as an indicator.
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OhDidItGetInYourEye
That mistletoe in my back pocket is for you.
12:33 PM on 10/07/2012
No, they're just more expensive. Oh, and bedazzled.
05:23 PM on 10/04/2012
So far, I believe in the research of Andrea Camperio Ciani et al. at the U. of Padova in Italy. Their studies show that "mothers and maternal aunts of gay men tend to have significantly more offspring than the maternal relatives of straight men. This is the "balancing selection hypothesis."
The theory holds that the same genetic factors that induce gayness in males also promote fecundity (high reproductive success) in their maternal female relatives." (Quotes from a piece by Natalie Wolchover on Lifes Little Mysteries, 6-12-12.)Theoreticallly, these women attract straight men in a stronger way for an as-yet-unknown reason, and these women could have babies ad infinitum. Having gay male children is therefore a natural population control. I know that this was true for me, as my third child was a gay male, and the Catholic church's "rhythm" method never worked for me as my periods were never standardized, but could range from 30 to 35 days. I got pregnant according to the saying of my mother-in-law "every time my husband hung his pants on the bedpost." So far, as a person with a college degree in science, this is what I believe, and my heart goes out to those males discovering that they are gay and do not want to be. As my son said at 16, "The guys were going ga-ga over girls, and I waited for it to happen to me, and it didn"t.)
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Jeff Rosenbury
I love all people -- in the abstract
02:03 PM on 10/04/2012
I once saw a study that estimated the primary cause of pre-contact, aboriginal, adult, male mortality was homicide. If this is the case, our ancestors were a blood thirsty lot. Being gay could have significantly increased survival odds in many such situations.

In addition, gene expression due to environmental factors is an area where more study is needed. It is possible gay genes are much more prevalent than assumed, but only express themselves under some environmental conditions (probably pre-natal). The continued existence of such genes could be due to some non-evolutionary emergent algorithm such as genetic drift.

Still, given how hard we've selected against gay genes for the past 2,500 years or so, it's a wonder any could survive. During much of the period, an outed gay person would be killed. Any decent pure evolutionary model can't explain it.

It's still a bit of a mystery.
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Filthy
05:14 PM on 10/04/2012
Evolution doesn't work on individuals, it works on alleles. That's why we evolved grandparents.
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12:23 PM on 10/04/2012
The fact is that many "Gay" men are actually just bi-sexual.
Men have sex with other men because it easier to have "zipless" sex with other men
than with most women.
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HotelDrama
03:47 PM on 10/04/2012
Or not.
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Filthy
05:09 PM on 10/04/2012
Is that what you tell yourself?
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07:23 PM on 10/04/2012
use to
11:01 AM on 10/04/2012
I always find it odd that in my family, of which I am the youngest of 5, that 4 are either gay or bi. The statistics on that were shot to >>>>.
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OhDidItGetInYourEye
That mistletoe in my back pocket is for you.
12:42 PM on 10/07/2012
Having an out gay person in the family sort of paves the way for others in the family to follow suit if that is indeed their inclination. That's not to say that is always the case, but it sure does make the transition much easier. Given this, I don't find it odd at all to see homosexuality "appear" to run in families. Most of the gay people I know are either the oldest or youngest sibling, and I've always suspected it had something to do with how those particular children in a brood tend to receive more coddling and over-mothering. Until we can actually read minds, we'll never know the true numbers...
09:07 AM on 10/09/2012
I can assure you I was not over coddled. And I highly doubt it was anything but genetic, as me and my sisters are almost mirror images of each other, except I'm the tallest at a whole 5 foot. (sorry about the digression, I make sure they always know I am the tallest)
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BeninOakland
Don't tell me you love me. Let me guess.
07:54 AM on 10/04/2012
Maybe the REAL answer is stunningly simple. There is no such thing as gay or straight. Everyone is born bisexual to some extent, and there are a pile of factors, some of them social, some familial, some genetic, some hard wired ( like being left handed or being tall), that come into play. he existence of homosexulatiy in many warm blooded species is a good indication of that.

I knew I was gay when I was three, long before I knew about sex, long before I heard the word or knew what it meant. I just didn't know what to call it. But it was real, and I knew it. When I finally came across the word in the dictionary, I KNEW it was me.
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HotelDrama
11:27 AM on 10/04/2012
But this doesn't seem to be the case in reality. And your second paragraph seems to contradict your first. If you knew you were gay, then it seems obvious that you were gay. I knew I was straight. I didn't, and you didn't, have a choice to be attracted to what you were/are attracted too. Its just who you are. No amount of social conditioning will change that. Cross cultural studies show a similar % of homosexuals in different cultures. This includes cultures that are much more accepting of different sexualities and genders, cultures on the opposite end where they execute gays, and cultures that actually have ritualized homosexuality. The numbers are the same. If culture played any sort of role in this, these numbers wouldn't be the same.
And as you say, the existence of homosexuality is species outside of humans, species that have much less 'culture' than humans, also indicates that sexuality isn't affected by 'culture.' It is a biological drive.
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12:24 PM on 10/04/2012
I cannot even remember being 3 years old.
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11:25 PM on 10/03/2012
I don't often care which comments I make get randomly blocked, but why you blocked my comment on genetic drift being the null hypothesis with humans, let alone all mammals, is beyond me.
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Albert Ray DOrazio
09:02 PM on 10/03/2012
Interesting. I don't know why God created me differently and uniquely but it's a bigger picture than we can ever imagine, I believe. I also find it interesting that my younger brother-who is exactly a year and two months apart from me-is gay as well and that my sister has 4 children.
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Marcusarilius
Marooned Star Traveler
08:42 PM on 10/04/2012
It was God who made a choice. A choice for YOU to be who you are.