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T. Colin Campbell, Ph.D.

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It's Time for an NIH Institute for Nutrition

Posted: 07/09/10 09:00 AM ET

By T. Colin Campbell, Professor emeritus of nutritional biochemistry at Cornell University and co-author with his son Thomas Campbell, MD, of "The China Study."

Finally, a long overdue scientific correction is happening. The human genome project is failing to advance the cause of human health, as promised. There is a fundamental but frustratingly and long overlooked reason why this is happening.

Working out the details of the human genome was worth doing, on several accounts: monitoring environmental pollutants, evaluating evolutionary lineages, identifying criminal suspects. But initially promising great advances in human health was not and should not have been one of these promises. Hypothesizing that knowledge of the associations of specific genes with serious diseases like cancer, heart disease and related diseases would lead to great health advances (through drug development) was a superficial and costly oversimplification of disease causation.

Although genes and/or their mutated forms are fundamental to the initiation of all disease events, it is not their mere presence or absence that determines disease outcomes. Genes may start the job but they do not finish it. The far more important question we should ask is: what controls the expression of genes (to produce products, mostly enzymes) that lead to health and disease events? Experimental and extensively published research from my laboratory over several decades has long convinced me that nutrition primarily provides this control. We have failed to acknowledge this question or sought its answer for far too long because we have failed to understand the scientific fundamentals of nutrition. Not one medical school in the nation adequately teaches this science, although a few give it lip service.

Still worse is the failure of federal funding agencies to recognize nutrition as a legitimate medical science. The National Institutes of Health, the most prominent biomedical research institution in the world, since its founding has kept nutrition well hidden. Not one of its 27 institutes and related centers is dedicated to nutrition! Some NIH administrators say nutrition is embedded in other programs but do not be fooled. First, dedicated nutrition funding is meager (less than five percent of the heart and cancer institutes--the two largest). Second, this small amount has been used primarily to study single nutrient effects in randomized clinical trials, a seriously flawed hypothesis.

Nutrition should not to be defined by the effects of isolated nutrients. That's pharmacology, a strategy now known not to work, in spite of the $25 billion or so that we annually spend on nutrient supplements. Unequivocal evidence now exists to show that nutrition, when provided by the use of whole, plant-based foods, can control the expression of our mischievous genes that otherwise would lead to serious ailments such as heart disease, diabetes, certain autoimmune diseases and many lesser ailments. For many years, experimental findings from my laboratory have shown that genetic initiation of cancer (by a powerful chemical carcinogen) can be stalled even reversed by a modest nutritional modification that is consistent with this same whole, plant-based food effect. (This research was funded by NIH because of my interest in cancer but, eventually, we learned that it was the tail, nutrition, that wagged the dog -- cancer.) Physician colleagues of mine, including Drs. Caldwell Esselstyn, Jr., Dean Ornish, Roy Swank and Neal Barnard have now published peer-reviewed findings showing this kind of nutrition not only to prevent serious diseases such as heart disease, diabetes and related ailments but to treat them into remission.

There is no other strategy in contemporary health science or medical practice that comes close to the breadth and depth of health benefits achievable by nutrition. We must begin to understand, communicate and apply this knowledge if we ever hope to reduce health care costs by reducing the burden of disease. We will never do this by depending on outmoded notions of what single (or even a few) genes, single nutrients or single chemicals (i.e., drugs) will do to create health. That thinking generates wealth for a few at the expense of health for the many. It is time to recognize the natural and harmonious biological complexity of health processes, and choose the lifestyle strategy that best maintains and restores that harmony. Nature has had eons of time to work this out. It's also time to develop a professional science of nutrition that serves the biological health of the population, not the economic health of commerce.

As for health professionals who claim they cannot convince patients to change their dietary practices, this is not surprising when the professionals themselves are not educated in this field and are vested in a strategy that is the antithesis of good nutrition. It is time we recognize what nutrition can do and a good place to start is to establish an NIH Institute of Nutrition dedicated for this purpose.


-- The writer is professor emeritus of nutritional biochemistry at Cornell
University. He is co-author with his son Thomas Campbell, MD, of "The China
Study."

 
By T. Colin Campbell, Professor emeritus of nutritional biochemistry at Cornell University and co-author with his son Thomas Campbell, MD, of "The China Study." Finally, a long overdue scientific cor...
By T. Colin Campbell, Professor emeritus of nutritional biochemistry at Cornell University and co-author with his son Thomas Campbell, MD, of "The China Study." Finally, a long overdue scientific cor...
 
 
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08:00 AM on 09/07/2010
Sorry, but I once again disagree that nutritional supplements are useless. Unless you are a true raw vegan that lives in a part of the world where fresh produce is a mere walk down the street then you need to be taking supplements to make up for this difference. Most people in industrialized (especially America) first world countries don't have this advantage.

And I think we can all agree that people eat way too much chemical junk.
09:23 PM on 08/14/2010
1.) Going on a vegan diet, I dropped my cholesterol 100 points and lost 35 pounds. Lipitor only dropped it 5 points.

2.) There are BILLIONS of dollars at stake. Dr's Campbell, Esselstyn, McDougall, Furhman, Ornish and more are threats to that income. Industry is going to fight to the death.

Thank you for providing sound science in the face of corporate giants.
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Sam1jere
Open-minded, sports lover, Red
06:32 AM on 07/22/2010
There are complexities regarding this topic, with acknowledgement to be made that with increasingly depleted soils, we're seeing less nutritious foods landing on our tables. The need for nutritional knowledge cannot be overstated however. What we do need is a balance between obsession with all things nutrition, the likes of which lead to concepts of what is "fat" and related diseases like anorexia; and deification of our bodies much like the ancient Greeks did.

How critical is the need for this knowledge? One only needs to look at the success of McDonalds to commence immediately! The earlier such knowledge can be inculcated the better for tomorrow's adults. I think all initiatives should target mothers, with significant interest in young mothers, so that they can in turn pass this to their offspring.

The government in addition to setting up a national nutrition institute can also offer such incentives as scholarships in this area and an encouragement to participate in such activity as community mobilizers. Use of pro athletes and big companies like Nike will certainly generate enough buzz among the young to take it to the next level.

This article to me is spot on.
07:08 PM on 07/23/2010
Actually we already have quite a bit of nutritional knowledge. We know the primary factor in weight loss/gain and the risk this contributes to some of the most high-impact diseases. We know the specific cause of a number of diseases which are the direct result of overabundance or deficiency of specific nutrients. You can go on about how we need information about nutrition but you leave out the most important part - in reference to what disease? What outcome would you be researching? Cancer? What evidence do we have that specific nutrients lead to cancer (as opposed to the effect of say over consumption). Obesity and anorexia are only meaningful when correlated against outcomes i.e. death, heart disease, etc... which as I've said - we already know with regard to the high-impact diseases.
07:38 PM on 07/20/2010
Colin's position is weird...and either unsupported by science or at odds with it. For some reason he states that all disease has a genetic precursor but requires a nutritional component. Current medical science says that only some diseases are considered to have a significant genetic influence. Candidates for this are revealed by things like MZ/DZ twin studies (especially with early onset diseases or if they use twins which are raised apart). Likewise we already know certain diseases have apparently no nutritional component because of their early onset. e.g. Rett syndrome is caused by mutation of MECP2.

His next bit is about nutrition via vitamins vs whole foods. Which again is weird we already know many diseases which are solely the result of vitamin deficiencies. There are on occasion some places where vitamins are used therapeutically (High dose Niacin for example). While I agree that much nutritional research looks at food people take and often (more often naturopaths rather than physicians) expressed as 'supplement with X'. Which isn't good science, since it's mistaking correlation ("people who eat foods with X don't get disease Y") with causation ("X prevents Y"). However Colin is going way overboard and suggesting that plants or animals (but given is other research probably only plants) contain some magical and optimal combination of nutrients. This is pure conjecture.
11:41 AM on 07/19/2010
Campbell would like to have a NIH so that he can promote his plant-based diet. He is not a reliable source of advice for anyone. His China Study has been under attack recently because of his apparent "cherry picking" of evidence to support his viewpoints. Very unprofessional and unscientific!

http://rawfoodsos.com/2010/07/07/the-china-study-fact-or-fallac/
03:44 PM on 07/22/2010
If you know anything about the scientific method and how its applied and you have a clue about science, then you cannot refute Campbells results with mere opinion. His evidence is overwhelming and his study methods/models are the best going. The shoddy website you reference has no validity and is worthless as a reliable source. Either get an education or don't opine and display your amazing ignorance. (Or it is more likely you work for Big Ag and this attempt to instill controversy over fact is your job.) Big Ag has all the answers don't be mislead by facts!
05:47 PM on 07/12/2010
Another NIH won't do anything. The one we have has more conflicts of interest than the Bush administration. It's like a pharma party over there.
05:46 PM on 07/12/2010
The position of the author is understandable,since trials of isolated nutritional elements, especially "antioxidants" such as vitamin A ,C and E have come up blank when tested prospectively in long term studies. The promoters of each new miracle diet or product are never required to refund the money for their bad advice.
So perhaps funding a new big government program on whole food nutrients is the answer. Unfortunately there are already many studies out there that don't point in this direction. For example this one showing only modest reduction in cancer for heavy vegetable consumption.
http://well.blogs.nytimes.com/2010/04/08/eating-vegetables-doesnt-stop-cancer/
Perhaps ,food is food,not medicine, a sensible way of looking at it.
06:15 AM on 07/15/2010
The median daily fruit and vegetable consumption in the study was a measly 335 grams, 3/4 of a pound-hardly "heavy vegetable consumption." This would not even satisfy the "5 a day servings" goal. French fries and ketchup count as vegetables.
A critique of the study:
http://www.diseaseproof.com/archives/cancer-fruits-and-vegetables-provide-only-modest-protection-from-cancer.html
02:29 PM on 07/16/2010
The Nurse's Health Study gave us some information, but certainly was not helpful in whether or not an increase in fruit & vegetable consumption protects against various cancers: the nurses consumed even MORE animal products than does the extremely high level consumed by someone on the SAD, Standard American Diet. And their F&V consumption wasn't very high. So why is it that this was used to say 'Fruits and Vegetables don't prevent cancer' by different media outlets? To sell papers? There is no valid reason.
02:46 PM on 07/12/2010
He's absolutely correct: "Nutrition should not to be defined by the effects of isolated nutrients. That's pharmacology". Unfortunately that mentality is driving the supplement industry, as well as a lot of misguided research that looks at intake of one nutrient and proclaims some result, ignoring the fact that intake of dozens of other nutrients impact the behavior of the one in question. The whole nutrition research industry is a mess. It's almost designed to make nutrition look irrelevant compared to prescription drugs. Or maybe not "almost".
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jamesinraro
10:43 AM on 07/12/2010
The NIH is deeply involved in supporting major research institutions doing medical research on supplements. One good example is the resveratrol study done by Albert Einstein Med Ctr. which was released at the recent meeting of the American Diabetes Association in Orlando. In this human clinical trial biotivia transmax, the standard resveratrol supplement used by the researchers, was shown to improve glucose tolerance, reduce blood sugar and enhance mitochondrial function better than some of the diabetes drugs, but without the adverse effects of these drugs. This study will move to phase II with a much larger subject population and the participation of the Mayo Clinic before the end of the year.
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TColinC
12:23 PM on 07/12/2010
Jamesinraro, yes, it is true that NIH for at least 25 years has funded many randomized clinical trials of the effects of isolated nutrients and related substances (in fact, what little money is spent on nutrition at NIH is mostly spent in this way), and presumably positive responses have been observed. But almost always these are short term effects that will not last. In fact, 3 major reports during the past 7-8 years have summarized these many trials and have concluded that there is no evidence for long term health benefits. In the meanwhile, people are led to believe that they are making progress and ignore much more lasting and substantial changes in their dietary lifestyle.

I am not a fan of randomized control trials for nutritional experimentation.
02:33 PM on 07/16/2010
But with the war on cancer and the war on many diet-related diseases the blindness is that we want to cure these with a pill, ignoring diet. When we finally wake up and get off the dairy and include studies where people eat more of a whole-food plant-based diet, we continue to see better results.
10:11 AM on 07/12/2010
Similar arguments could be made for wellness in general...the study of exercise, for example. Indeed, the NIH and medical education generally focus on disease, not health. How about a National Institute for Wellness?
09:50 AM on 07/12/2010
The amount of meat, cheese, eggs, and processed junk people eat is sickening. I'm glad Dr. Campbell is trying to convince people to eat healthier. I've been a vegan for many years and I've never felt better. With all the delicious and nutritious vegan foods around, it's illogical for people to stuff their faces with fatty, cholesterol-laden animal products and chemical-based crap.
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ratstar
10:06 PM on 07/11/2010
perfectly put. processed foods are more readily accessible. i travel on a bus all the time and i'm stuffed full of snacks and fast food. it's nice when one has time at home to have a salad of chopped greens. sometimes i bring a piece of fruit or a bag of nuts on the go.
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TColinC
10:04 PM on 07/11/2010
You do not know what is a low fat diet. You are probably thinking of one that is about 30% fat (instead of about 35-40% fat), one that is still high in protein, animal based foods and processed foods. Such a diet represents only a modest change that does not improve health. It may be worse for people like you. The worsening of health and dietary practices in this country had nothing to do with that modest change.

After conducting experimental diet and health research while using your money (mostly NIH) for more than 40 years and publishing it in the best peer-reviewed journals, our work and that of others overwhelmingly shows that health improvement is dramatic, involving both prevention of future disease and resolving current illnesses using a whole foods, plant-based diet with a natural fat level of about 10-12% of calories, nothing like your impressions of a not-so-low 30% fat diet. For more information, read books by Drs. Neal Barnard, Caldwell Esselstyn, John McDougall, Joel Fuhrman and myself and my son (The China Study).

Based on your obvious misinformation, I suggest that you look at yourself before accusing others of being a charlatan. Those who judge others so carelessly, judge themselves.
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mssreader
eat, read, sleep, read and be happy
12:39 PM on 07/12/2010
TColinC, is the the China Study still ongoing?

I'm always being asked, "but where do you get our protein" and my answer is usually, "where do cows and steer get their protein". I don't get asked about fat though people tell me they couldn't live without butter though if they stopped to think about it they would see that I manage very well without dairy products and meat. People are just too attached to food not realizing the purpose of food..
01:38 PM on 07/12/2010
I believe pastured cows and steer get their protein from converting the cellulose in grass to amino acids. Unfortunately, humans are unable to do this for lack of a rumen.

Grain fed cows are often given protein supplements.
11:43 AM on 07/19/2010
The China Study has been shown to have a number of flaws, including Campbell picking evidence to support his viewpoint. He doesn't talk about the correlations that plant-based diets have with cancer or other ailments (wheat has much higher correlations than meat).

Here is an independent review of his "research":
http://rawfoodsos.com/2010/07/07/the-china-study-fact-or-fallac/
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RMankovitz
Researcher, inventor, entrepreneur, author
10:42 AM on 07/11/2010
I suggest the formation of an Office of Illness Prevention (OIP). It must be independent of: the food industry, the industry-controlled FDA/EPA/USDA triangle, Big Pharma, the medical community, the Surgeon General, the NIH, and even the herbal and supplement industries. It would conduct government funded university research into areas that have been completely ignored, such as using nature as a paradigm for health. I have personally already funded such research with great results. Ask your librarian for a copy of "The Wellness Project" for details.

The OIP would include an anti-revolving-door policy to avoid being compromised by other institutions. All of the research would be posted free to the world community, and there would be open dialog between consumers and the OIP via the web. New professional designations would be created for Illness Prevention Practitioners. Nature-based prevention (as opposed to "preventive medicine," an oxymoron invented by BigPharma to sell drugs) would be part of a mandatory curriculum taught in every medical and nursing school. Ultimately, true illness prevention would become a worldwide initiative, changing the face of health and health care as we know it.

Roy Mankovitz, Director
http://www.MontecitoWellness.com
05:48 PM on 07/10/2010
a much better solution is to defund NIH. Can you name a single disease they have found a cure for? can you name a single medical outbreak that they stopped?
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TColinC
09:12 AM on 07/11/2010
Somehow there is a serious mis-communication here. The 'research' funding that NIH administers is mostly 'extramural' meaning that its assignment is controlled by people outside of NIH. The research grants that are awarded are determined by 'peers' outside of NIH with no input from NIH. NIH also is, far and away, the main source of biomedical research funding, the main source of funding in the world. Are you saying that research should not be done on nutrition? Or, that it should be done by industry or government bureaucrats?

I agree that NIH needs to seriously re-think their priorities on nutrition but why let the private sector do all the research?

Incidentally, AIDS research was heavily supported by NIH funding--any lack of progress is more political and economic than scientific.
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mssreader
eat, read, sleep, read and be happy
01:44 PM on 07/11/2010
TColinC, I hope you are the real T.Colin Campbell and if so, may I request more of your bloggs on HP. I keep looking for another book from you as a follow up on China Study. I can't say more unless I know you are the real C. Colin Campbell because I'd look silly.