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Adaptive Mutation

Evelyn Witkin, Jean Weigle, the SOS Response and How E. Coli Generates Mutations in Response to UV Irradiation

James A. Shapiro | Posted 12.20.2012 | Science
James A. Shapiro

Whether we will discover more examples of adaptive action by fascinating mutagenic enzymes is a question definitely on the 21st Century research agenda. Finding them would be an important contribution to contemporary evolution science.

Experimental Evolution: How Can We Watch Natural Genetic Engineering in Real Time?

James A. Shapiro | Posted 08.25.2012 | Science
James A. Shapiro

I have argued that natural genetic engineering is the real creative process in evolutionary innovation. A central but undocumented feature of my argument is that cells can coordinate separate DNA-change events to produce functional new genome structures.