The Prometheus of Greek myth was the titan who stole fire -- and a love of science and the intellect -- from the gods of Olympus. If Ol' Pro' saw this eponymous film, he might keep the fire but give the rest back.
It's about a lot of things. The beginnings of life. Man's place in the universe. But most importantly, it's about Scott returning to the genre he served so well and that in turn served him so well, to prove he still has what it takes to make his mark.